Academic Staff

Heng, Alexis Boon Chin

Dr Heng, Alexis Boon Chin

BSc (UK), MCE (Singapore), PhD (UK)

Title: Post-doctoral Fellow in Biomedical and Tissue Engineering
Discipline area: Endodontology
Tel: 2859 0527

Areas of Research Expertise

  1. Biomaterials
  2. Stem cells
  3. Regenerative medicine
  4. Tissue engineering

Faculty Research Group

Selected Latest Publications


  1. XU J, Zhu S, Heng BCA, Dissanayaka WL & Zhang C. TGF-β1-induced differentiation of SHED into functional smooth muscle cells. Stem Cell Research & Therapy 2017;8(10). doi:10.1186/s13287-016-0459-0
  2. GONG T, Heng BCA, XU J, Zhu S, YUAN C, Lo ECM & Chen Q. Decellularized extracellular matrix of human umbilical vein endothelial cells promotes endothelial differentiation of stem cells from exfoliated deciduous teeth. Journal of Biomedical Materials Research Part A 2017;105:1083-1093. doi:10.1002/jbm.a.36003
  3. Heng BCA, GONG T, Wang S, Lim LW, Wu W & Zhang C. Decellularized Matrix Derived from Neural Differentiation of Embryonic Stem Cells Enhances the Neurogenic Potential of Dental Follicle Stem Cells. Journal of Endodontics 2017;43(3):409-416. doi:10.1016/j.joen.2016.10.033
  4. ZOU T, Dissanayaka WL, Jiang S, Wang S, Heng BCA, Huang X & Zhang C. Semaphorin 4D Enhances Angiogenic Potential and Suppresses Osteo-/Odontogenic Differentiation of Human Dental Pulp Stem Cells. Journal of Endodontics 2017;43:297-305. doi:10.1016/j.joen.2016.10.019
  5. Heng BCA, Zhang C, Deng X, Xiao Y, Pisciotta A, Kidwai F & Mitsladis TA. Biomedical Applications of Dental and Oral-Derived Stem Cells. Stem Cells International 2017;2017:1-2. doi:10.1155/2017/2931054
  6. Zhu S, Wang PL, Liao C, Yang Y, YUAN C, WANG S, Dissanayaka WL, Heng BCA & Zhang C. Transgenic expression of ephrinB2 in periodontal ligament stem cells (PDLSCs) modulates osteogenic differentiation via signaling crosstalk between ephrinB2 and EphB4 in PDLSCs and between PDLSCs and pre-osteoblasts within co-culture. Journal of Periodontal Research 2016;. doi:10.1111/jre.12424
  7. YUAN C, Wang P, Zhu S, ZOU T, Wang S, XU J, Heng BCA, Diogenes A & Zhang C. EphrinB2 Stabilizes Vascularlike Structures Generated by Endothelial Cells and Stem Cells from Apical Papilla.. Journal of Endodontics 2016;42:1362-1370. doi:10.1016/j.joen.2016.05.012
  8. Deng Z, Wang S, Heng BCA, YUAN C & Zhang C. Enterococcus faecalis promotes osteoclast differentiation within an osteoblast/osteoclast co-culture system. Biotechnology Letters 2016;38:1443-1448. doi:10.1007/s10529-016-2142-z
  9. Zhang X, Wu Y, Pan Z, Sun H, Wang J, Yu D, Zhu S, Dai J, Chen Y, Tian N, Heng BCA, Coen ND, Xu H & Ouyang H. The effects of lactate and acid on articular chondrocytes function: Implications for polymeric cartilage scaffold design. Acta Biomaterialia 2016;. doi:10.1016/j.actbio.2016.06.029
  10. Heng BCA, Ye X, LIU Y, Dissanayaka WL, Cheung GSP & Zhang C. Effects of Recombinant Overexpression of Bcl2 on the Proliferation, Apoptosis, and Osteogenic/Odontogenic Differentiation Potential of Dental Pulp Stem Cells. Journal of Endodontics 2016;42:575-583. doi:10.1016/j.joen.2016.01.013

  To Top