Academic Staff

Heng, Alexis Boon Chin

Dr Heng, Alexis Boon Chin

BSc (UK), MCE (Singapore), PhD (UK)

Title: Post-doctoral Fellow in Biomedical and Tissue Engineering
Discipline area: Endodontology
Tel: 2859 0527

Areas of Research Expertise

  1. Biomaterials
  2. Stem cells
  3. Regenerative medicine
  4. Tissue engineering

Faculty Research Group

Selected Latest Publications


  1. Xiong S, Zhang X, Lu P, Wu Y, Wang Q, Sun H, Heng BCA, Bunpetch V, Zhang S & Ouyang H. A Gelatin-sulfonated Silk Composite Scaffold based on 3D Printing Technology Enhances Skin Regeneration by Stimulating Epidermal Growth and Dermal Neovascularization. Scientific Reports 2017;7. doi:10.1038/s41598-017-04149-y
  2. XU J, Zhu S, Heng BCA, Dissanayaka WL & Zhang C. TGF-β1-induced differentiation of SHED into functional smooth muscle cells. Stem Cell Research & Therapy 2017;8(10). doi:10.1186/s13287-016-0459-0
  3. XU J, GONG T, Heng BCA & Zhang C. A systematic review: differentiation of stem cells into functional pericytes. The FASEB Journal 2017;31:1775-1786. doi:10.1096/fj.201600951RRR
  4. Zhou C, Meng J, Zhao C, Ye C, Zhu H, Hu B, Heng BCA, Shen Y, Lin T, Yang X, Shi Z, Shen W, Yan S & Miao D. PTH[1-34] improves the effects of core decompression in early-stage steroid-associated osteonecrosis model by enhancing bone repair and revascularization. PLOS ONE 2017;12:e0178781. doi:10.1371/journal.pone.0178781
  5. GONG T, Heng BCA, XU J, Zhu S, YUAN C, Lo ECM & Chen Q. Decellularized extracellular matrix of human umbilical vein endothelial cells promotes endothelial differentiation of stem cells from exfoliated deciduous teeth. Journal of Biomedical Materials Research Part A 2017;105:1083-1093. doi:10.1002/jbm.a.36003
  6. Zheng Z, Ran J, Chen W, Hu Y, Zhu T, Chen X, Yin Z, Heng BCA, Feng G, Le H, Tang C, Huang Y, Chen Y, Zhou Y, Dominique P, Shen W & Ouyang H. Alignment of collagen fiber in knitted silk scaffold for functional massive rotator cuff repair. Acta Biomaterialia 2017;51:317-329. doi:10.1016/j.actbio.2017.01.041
  7. Heng BCA, GONG T, Wang S, Lim LW, Wu W & Zhang C. Decellularized Matrix Derived from Neural Differentiation of Embryonic Stem Cells Enhances the Neurogenic Potential of Dental Follicle Stem Cells. Journal of Endodontics 2017;43(3):409-416. doi:10.1016/j.joen.2016.10.033
  8. ZOU T, Dissanayaka WL, Jiang S, Wang S, Heng BCA, Huang X & Zhang C. Semaphorin 4D Enhances Angiogenic Potential and Suppresses Osteo-/Odontogenic Differentiation of Human Dental Pulp Stem Cells. Journal of Endodontics 2017;43:297-305. doi:10.1016/j.joen.2016.10.019
  9. Heng BCA, Zhang C, Deng X, Xiao Y, Pisciotta A, Kidwai F & Mitsladis TA. Biomedical Applications of Dental and Oral-Derived Stem Cells. Stem Cells International 2017;2017:1-2. doi:10.1155/2017/2931054
  10. Zhu S, Wang PL, Liao C, Yang Y, YUAN C, WANG S, Dissanayaka WL, Heng BCA & Zhang C. Transgenic expression of ephrinB2 in periodontal ligament stem cells (PDLSCs) modulates osteogenic differentiation via signaling crosstalk between ephrinB2 and EphB4 in PDLSCs and between PDLSCs and pre-osteoblasts within co-culture. Journal of Periodontal Research 2016;. doi:10.1111/jre.12424

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