Academic Staff

Leung, Wai Keung

Professor Leung, Wai Keung

BDS, MDS (HK), PhD (British Columbia), FHKAM (Dental Surgery), FCDSHK (Perio), FDS RCSEd

Title: Clinical Professor in Periodontology
Discipline area: Periodontology
Tel: 2859 0417
Research profiles: HKU Scholars Hub Scopus Biomedexperts Researcher ID ORCID

Areas of Research Expertise

  1. Human periodontal microbial ecology and virulence
  2. Effects of altered human oral physiology on the corresponding microbial ecology
  3. Clinical trials of periodontal care strategies

Faculty Research Group

Selected Latest Publications


  1. PERRY S, Bridges SM, Zhu FF, Leung WK, Burrow MF, Poolton JM & Masters RSW. Getting to the root of reinvestment - an fNIRS study in dentistry using virtual reality haptic simulation. Journal of Medical Internet Research 2017;.
  2. Tan SK, Leung WK, Tang ATH & Zwahlen RA. Effects of mandibular setback with or without maxillary advancement osteotomies on pharyngeal airways: An overview of systematic reviews. PLOS ONE 2017;12:e0185951. doi:10.1371/journal.pone.0185951
  3. Tan SK, Leung WK, Tang ATH & Zwahlen RA. Letter to the editor on the article “Impact on the upper airway space of different types of orthognathic surgery for the correction of skeletal class III malocclusion: A systematic review and meta-analysis”. International Journal of Surgery 2017;45:156-157. doi:10.1016/j.ijsu.2017.03.083
  4. TAN SK, Leung WK, Tang ATH & Zwahlen RA. How does mandibular advancement with or without maxillary procedures affect pharyngeal airways? An overview of systematic reviews. PLOS ONE 2017;12:e0181146. doi:10.1371/journal.pone.0181146
  5. PERRY S, Burrow MF, Leung WK & Bridges SM. Simulation and curriculum design: A global survey in dental education. Australian Dental Journal 2017;. doi:10.1111/adj.12522
  6. Yeung WKA, Goto TK & Leung WK. At the Leading Front of Neuroscience: A Bibliometric Study of the 100 Most-Cited Articles. Frontiers in Human Neuroscience 2017;11:363. doi:10.3389/fnhum.2017.00363
  7. You M, Chan YK, Lacap-Bugler DC, Huo YB, Gao W, Leung WK & Watt RM. Oral treponeme major surface protein: Sequence diversity and distributions within periodontal niches. Molecular Oral Microbiology 2017;. doi:10.1111/omi.12185
  8. Goh V, Hackmack PP, Corbet EF & Leung WK. Moderate- to long-term periodontal outcomes of subjects failing to complete a course of periodontal therapy. Australian Dental Journal 2017;62:152-160. doi:10.1111/adj.12440
  9. Yeung WKA & Leung WK. Review of Docphin: An App for Mobile Access to Medical Journals. Journal of Digital Imaging 2017;30:130-132. doi:10.1007/s10278-016-9925-6
  10. Yeung WKA, Goto TK & Leung WK. The Changing Landscape of Neuroscience Research, 2006–2015: A Bibliometric Study. Frontiers in Neuroscience 2017;11:120. doi:10.3389/fnins.2017.00120

Books and Chapters

  1. Goh V, Goo CL & Leung WK. Prevention of peri-implantitis should start at treatment planning. In Advances in Medicine and Biology.1162017,pp.Chapter 9, pp. 129-199.
  2. WANG X, CHEN Y & Leung WK. Role of the Hypoxia-Inducible Factor in Periodontal Inflammation. In Hypoxia and Human Diseases.2017,pp.285-302.
  3. Zheng Y, Song Y & Leung WK. Periodontitis: A Common Oral Disease the Genetic Susceptibility. In Advances in Genetics Research.152015,pp.99-125.
  4. Goh V, Nihalani D & Leung WK. Periodontal Disease and Oral Health-Related Quality of Life. In Oral Health: Social Determinants, Role of Nutrition and Impact on Quality of Life.12015,pp.1-31.
  5. YOU M, Watt RM & Leung WK. Chapter XI: Diversity of Oral Spirochetes and Their Role as Periodontopathogens. In Current Trends in Periodontics and Implant Dentistry.2013,pp.199-214.
  6. Chai L & Leung WK. Influences of systemic diseases on periodontal health. In Current Trends in Periodontics and Implant Dentistry.II2013,pp.19-40.
  7. Cheng RHW, Yiu CKY & Leung WK. Oral Health in Individuals with Down syndorme. In Prenatal Diagnosis and Screening for Down Syndrome.2011,pp.59-76.
  8. Chai L, Corbet EF & Leung WK. Genetic polymorphisms and periodontitis. In Periodontitis symptoms, treatment and prevention.2010,pp.209-219.

Research Grants

Principal Investigator :

  1. 2015-: In vitro study of salivary pellicle formation on dental restorative material surfaces. [Small Project Funding] (HKD72,618)
  2. 2015-2015: Turning risk into opportunity: biology of biofilm formation on dental restorative materials – maximizing the anti-plaque potential of fillings [Seed Funding Programme for Basic Research] (HKD43,000)
  3. 2015-2018: Genetic risks for chronic periodontitis: A genome-wide association study [Health and Medical Research Fund - Full Grant] (HKD999,980)
  4. 2014-2017: Protective effect of oral lining cells against anaerobic periodontal infection: Does microbe associated molecular pattern recognition interact with hypoxic preconditioning? [General Research Fund (GRF)] (HKD602,390)
  5. 2014-2015: The role of periodontal resident cell TLR4 signaling and HIF-1α biology in modulating autophagy in human chronic periodontitis [Small Project Funding] (HKD80,000)
  6. 2013-2015: Comparison of subgingival bacterial profiles in chronic periodontitis subjects with and without type 2 diabetes by 16S rRNA pyrosequencing [Small Project Funding] (HKD78,000)
  7. 2012-2015: Four-dimensional analysis of human higher brain function during eating: functional MRI study of taste, mastication, and swallowing [General Research Fund (GRF)] (HKD1,006,236)
  8. 2012-2013: Hypoxia-inducible factor (HIF)-1 alpha regulates expression of Toll-like Receptors (TLR) in human gingival resident cells [Small Project Funding] (HKD80,000)
  9. 2011-2012: Hypoxia-inducible Factor 1 Alpha Induces Human Gingival Keratinocytes to Express Functional Toll-Like Receptor 4 in vitro and in vivo [Small Project Funding] (HKD49,654)
  10. 2010-2014: Impacts of patient-centered periodontal disease management on oral health-related quality of life. [General Research Fund (GRF)] (HKD1,237,000)

Co-Investigator :

  1. 2014-: Subgingival microbiota in patients with early and established rheumatoid arthritis [Seed Funding Programme for Basic Research] (HKD83,800) (with et al)
  2. 2014-: Role of low dose bisphosphonate in compromised host with preriodontal diseases: risk or benefit? [Seed Funding Programme for Basic Research] (HKD35,800) (with ZHENG Li Wu et al)
  3. 2014-: Whats in your pockets? Single-site analysis of Treponema and Synergistetes populations associated with periodontal health and disease [General Research Fund (GRF)] (HKD619,525) (with WATT, Rory M et al)
  4. 2013-: Application of minimal invasive non-surgical periodontal technique on periodontal therapy [Seed Funding Programme for Basic Research] (HKD120,000) (with Ho, Dominic King Lun et al)
  5. 2013-: A Pilot Study of the Total Microbial Community in Periodontitis Patients using Next Generation Sequencing [Small Project Funding] (HKD69,575) (with Lacap-Bugler, Donnabella Castillo et al)
  6. 2013-: Role of Denosumab in inducing jawbone osteonecrosis on a rat model [Seed Funding Programme for Basic Research] (HKD67,300) (with ZHENG Li Wu et al)
  7. 2013-: Investigation of biofilm formation on dental materials [Small Project Funding] (HKD80,000) (with BURROW, M.F. et al)
  8. 2013-: Molecular analysis of Synergistetes communities associated with chronic and aggressive forms of periodontitis [Seed Funding Programme for Basic Research] (HKD100,900) (with WATT, Rory M et al)
  9. 2013-: Impact of oral bacteria on unmasking bisphosphonate-related osteonecrosis of the jaws [General Research Fund (GRF)] (HKD639,000) (with ZHENG Li Wu et al)
  10. 2012-: Role of oral bacteria in unmasking bisphosphonate-related osteonecrosis of the jaws [Seed Funding Programme for Basic Research] (HKD51,000) (with ZHENG Li Wu et al)

Honours and Awards

  1. Proteomic evaluating salivary acquired pellicle on restorative material surfaces 2016 IADR Heraeus Kulzer Travel Award and 1st runner's up IADR-SEA Unilever Hatton Division Award, 30th Annual Scientific Meeting (2016) of the International Association for Dental Research. 2016. WEI C, Burrow MF, Botelho MG & Leung WK.
  2. Research Award in Periodontology and Microbiology, 29th Annual Scientific Meeting (2015) of the International Association for Dental Research, South-east Asian Division International Association for Dental Research South-east Asian Division. 2015. Watt RM, YU X, Chan YK & Leung WK.
  3. Best Paper Award in Microbiology / Immunology / Periodontal Research 26th IADR-SEA Annual Scientific Meeting. 2012. Leung WK, You M, Mo S & Watt RM.
  4. Listerine Award in Investigative Periodontology Conjoint Scientific Meeting and 1st Guangdong-Hong Kong Postgraduate Forum in Dental Science. 2010. Mo S, You M, Leung WK & Watt RM.
  5. Faculty Research Output Prize 2010, Faculty of Dentistry, The University of Hong Kong, June 2010: Microbiology Of Odontogenic Bacteraemia: Beyond Endocarditis. Clinical Microbiology Reviews. 2009. Parahitiyawa NB, Jin LJ, Leung WK, Yam WC & Samaranayake LP.
  6. Best presentation (Behavioral Science and Health Service Research) in the 22nd Meeting of International Association for Dental Research Annual - Southeast Asian Division. Manila, Philippines; Oct 8-10, 2008 International Association for Dental Research Annual - Southeast Asian Division. Manila, Philippines; Oct 8-10, 2008. 2008. CHENG HF, LEE YM, Chu CH, Leung WK & Mok TMY.


  1. Journal Editor (Hong Kong Medical Journal) 2008
  2. Editor-in-Chief (Hong Kong Dental Journal) 2007
  3. Editor-in-Chief (Hong Kong Dental Journal) 2006
  4. Deputy Editor (Hong Kong Dental Journal) 2004

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