2022 TU-HKU-FJMU Symposium

About Speakers

Invited Lecture Series 1

Career Paths for Dental Graduates
Dr Hao YU
Dr Hao YU

Topic

Career Paths for Dental Graduates of Mainland China

Abstract

In mainland China, there are approximately 100 colleges and universities that recruit dental graduates majoring in stomatology. Dental graduates have various choices of career paths after graduation. The aim of this lecture is to provide a framework for dental students to use so that they can explore various opportunities after dental school.

Biography

Dr Hao Yu is an associate dean and an associate professor (Prosthodontics) at the School and Hospital of Stomatology of Fujian Medical University, and adjunct professors at the dental schools of University of Zurich and Nagasaki University. He is the vice president of Fujian Prosthodontics and Dental Materials Society, the vice president of Western Returned Scholars Association, Fujian Medical University, a member of standing committee of Chinese Prosthodontics Society, a committee member of Chinese Dental Materials Society, a council member of Fujian Stomatological Association, and a council member of Fujian Physician Association. He is elected as a Fellow of International College of Dentists (FICD). Dr Yu’s research interests include dental materials, tooth bleaching, prevention of dental erosion, and dental education. Dr Yu published more than 100 peer reviewed journal articles and abstracts in international conferences. He is a Guest Editor of BioMed Research International and Frontiers in Materials. He received Science & Technology Award for Young Talents of Fujian Province in 2021.

Professor Chun Hung CHU
Professor Chun Hung CHU

Topic

Career Paths for Dental Graduates of Hong Kong

Abstract

Dental graduates in Hong Kong have a variety of career paths to choose from based on their work desire in such as clinical practicing, further studying and training, or conducting research. The Faculty of Dentistry, the University of Hong Kong (HKU) is the only institution to provide dental education and undergraduate dental degree in Hong Kong. After 6-year learning and training, HKU dental graduates commonly secure gainful employment in the field of dentistry shortly after graduation. In Hong Kong, a major job option opens to dental graduates is practicing dentistry in private sector. They can choose to practice solo or in partnership with other dentists. Besides, dental graduates can join the Department of Health as a government dentist or practice as a hospital-based (non-governmental) dentist in the Prince Philip Dental Hospital (PPDH, the only dental hospital in Hong Kong) or in the maxillofacial dental units of general hospitals. Instead of jumping into job market, dental graduates can choose to have advanced clinical training in the discipline that they are interested in. A few dentists join the on-job advanced clinical training in the Development of Health, whereas most dentists pursue their clinical training through a fulltime 3-year Master degree programme. Those who find their interest in conducting research and want to work in academia often go for training as MPhil or PhD (both full-time and part-time) students. The aim of this talk is to help dental students to gain an insight into various career paths and to prepare for further career development after graduation.

Biography

Dr Chu is a Professor and Associate Dean of the Faculty of Dentistry, The University of Hong Kong (HKU) with a demonstrated history of working in the clinical dentistry, administration and leadership, clinical and basic research, and higher education. He is the President, the Society of Preventive Dentistry of Hong Kong (2021-23), the President, the Asia Academy of Preventive Dentistry (2021-23), a Member, the FDI Public Health Committee (2021-24), and the Immediate Past President, the South East Asians Association for Dental Education (2021-23). Dr Chu practiced dentistry for 15 years and was the dental surgeon in charge of the HKU Health Service before he became an academics. He is a fellow of the Hong Kong College of Dental Surgeons, a fellow of the Hong Kong Academy of Medicine and a registered specialist in Family Dentistry in Hong Kong. Through overseas examinations, Dr Chu became a fellow of the Royal Australasians College of Dental Surgeons (RACDS) in Sydney, a dental fellow of the Royal College of Surgeons in Edinburgh (RCSEd) UK, and a diplomate of the American Board of General Dentistry in Chicago. He lectured widely in international conferences. Through his exceptional achievements in clinical care, teaching and research, Dr Chu was elected as a fellow of the International College of Dentists, a fellow of the Faculty of Dental Trainers RCSEd and a fellow of the Academy of Dental Materials, respectively. He published extensively with a Scopus h index of 40. He is an editor of several SCI journals.

Professor Guang HONG
Professor Guang HONG

Topic

Career Paths for Dental Graduates of Japan

Abstract

In Japan, 29 dental colleges or universities (11 national, 1 public, 17 private) in Japan. The almost case of the way of entering them is after high school. And no matter which university students enter, they must take a set six-year curriculum. When students complete all proper processes of dental school, they could allow taking a Dental national examination. In my presentation, I will provide the information of the career paths of dental students in Japan, and discuss how to bring out the potential of the students.

Biography

Professor Guang Hong is an associate dean and an associate professor (Prosthodontics) at the School and Hospital of Stomatology of Fujian Medical University, and adjunct professors at the dental schools of University of Zurich and Nagasaki University. He is the vice president of Fujian Prosthodontics and Dental Materials Society, the vice president of Western Returned Scholars Association, Fujian Medical University, a member of standing committee of Chinese Prosthodontics Society, a committee member of Chinese Dental Materials Society, a council member of Fujian Stomatological Association, and a council member of Fujian Physician Association. He is elected as a Fellow of International College of Dentists (FICD). Dr Yu’s research interests include dental materials, tooth bleaching, prevention of dental erosion, and dental education. Dr Yu published more than 100 peer reviewed journal articles and abstracts in international conferences. He is a Guest Editor of BioMed Research International and Frontiers in Materials. He received Science & Technology Award for Young Talents of Fujian Province in 2021.

Invited Lecture Series 2

Oral Medicine and Endodontics
Dr Keisuke NAKAMURA
Dr Keisuke NAKAMURA

Topic

Dental applications of photochemical and photobiological reactions induced by ultraviolet-A irradiation

Abstract

Ultraviolet-A (UVA) is defined as an electromagnetic wave having a wavelength between 315 and 400 nm. Owing to its high photon energy, UVA causes various photochemical and photobiological reactions. In our laboratory, we have studied beneficial effects of UVA in dentistry. For instance, we have developed an antimicrobial technique in which UVA irradiation of hydrogen peroxide is performed to generate hydroxyl radicals. As hydroxyl radicals are potent oxidant, they cause lethal oxidative damage on bacterial cells even in biofilm. This antimicrobial technique can be adjunctively used in treatment for dental infectious diseases. Another example is to use UVA to trigger tertiary dentin formation. We found that tentative and mild oxidative stress was induced in dental pulp when a rat tooth was irradiated with UVA. As a result, tertiary dentin was formed during the tissue repair process. This effect may be applicable to protect vital dental pulp in caries treatment. In this lecture, these topics will be discussed.

Biography

Keisuke Nakamura is Associate Professor at the Department of Advanced Free Radical Science, Tohoku University Graduate School of Dentistry in Japan. He received undergraduate training at Tohoku University School of Dentistry (DDS, 2002) and postgraduate education in prosthodontics and dental material science at Tohoku University Graduate School of Dentistry (PhD, 2006). He joined a research project for 1 year at Institute of Odontology, the University of Gothenburg in Sweden in 2007. Then, he started his second postgraduate project on dental ceramic material at the University of Gothenburg and received PhD degree in 2015. His PhD thesis was awarded as “Best Thesis 2015 at Institute of Odontology”. He has also been involved in a research project at Tohoku University since 2008, where antimicrobial techniques utilizing free radicals are developed for treatments of dental infectious diseases. His research achievements were awarded the “Research Encouragement Award” from Intelligent Cosmos Scientific Foundation in 2012.

Dr Li-wu ZHENG
Dr Li-wu ZHENG

Topic

Oral Lichen Planus and Oral Lichenoid Lesions: A Clinical Update

Abstract

Oral lichen planus (OLP) is a chronic immunological disorder affecting the oral mucosa. The WHO set the diagnostic criteria for OLP in 1978 and classify it as oral potentially malignant disorders. The oral lichenoid lesions (OLL) and oral lichenoid dysplasia (OLD) are not distinguished from OLP in this criteria while they share similar clinical and histological features. In 2003 a modified WHO criteria attempting to differentiate OLP, OLL and OLD was proposed. However, the debate on whether these lesions are different diseases or a continuum of the same condition has never ended. Under certain circumstance, the term “oral lichenoid conditions” is used to club these lesions. Here a clinical update of the diagnosis, management and malignant transformation of the oral lichenoid conditions is discussed.

Biography

Dr ZHENG Li-wu, DDS, MD, PhD, is a clinical associate professor of Oral Medicine at the Faculty of Dentistry, the University of Hong Kong, and an adjunct associate professor in School of Dental Medicine, University Pennsylvania. He serves as the undergraduate programme director of Oral & Maxillofacial Surgery, chief examiner of BDS IV, and chairman of PBL problem development group (BDS V). Dr Zheng is a member of Chinese Specialty Committee on Oral Mucosal Diseases and American Academy of Oral Medicine, and serves as section editor in several reputed dental and medical journals. The current research interest of Dr Zheng is AI in prediction of malignant transformation of oral mucosal lesions. He supervised and is supervising 15 PhD students, and has published a total of 2 books, 96 peer reviewed journal articles, 2 dissertations, and 7 book chapters. To promote Oral Medicine in China, Dr Zheng organized the translation and publication of 2 authoritative text books with People’s Medical Publishing House.

Dr Jia HU
Dr Jia HU

Topic

Regenerative Endodontics for Adult Patients with Immature Apices

Abstract

The difficulty in endodontic treatments of adult patients with immature apices lies in the formation of a three-dimensional apical sealing to prevent reinfection. In 2013, the American Association of Endodontics (AAE) first issued guidelines for regenerative endodontic procedures, and updated them to promote the regenerative treatment of infected immature permanent teeth in children and adolescents in 2016, 2018, and 2021. Can the concept of regenerative endodontics be extended to revitalize immature permanent teeth with pulp necrosis or periapical lesion in adults? Here the clinical efficacy is analysed to explore the question if regenerative endodontic therapies should be developed for dental pulp and/or dentin regeneration in adults with immature apices.

Biography

Dr Jia Hu works as an attending dentist and lecturer at the School and hospital of Stomatology, Fujian Medical University. She obtained her BDS to MDD degree from the School of Stomatology, Peking University. Her research focuses on the regenerative endodontics. Dr Hu is a Youth member of the Endodontic Professional Committee, Fu Jian Province. She participated in the translation and publication of 2 books and held 4 scientific research projects.

Invited Lecture Series 3

Orthodontics and Digital Dentistry
Dr Hideki KITAURA
Dr Hideki KITAURA

Topic

Accelerated Orthodontic Tooth Movement by Micro-osteoperforations

Abstract

A key concern for orthodontics is the lengthy duration of orthodontic treatment. Therefore, shortening the duration of orthodontic treatment is an active research area. Many methods have been tested to accelerate tooth movement, including biological, mechanical, physical and surgical approaches. Surgical procedures are the most consistent and achieve the desired results. Perforation of the alveolar bone is a surgical method that is termed micro-osteoperforations (MOPs), and MOPs can be used to accelerate orthodontic tooth movement. In our previous study, compression force in orthodontic tooth movement induces expression of TNF-α and induced osteoclast formation and bone resorption. We also found that TNF-α plays important roles in an orthodontic tooth movement mouse model by using both TNF receptor-1 and TNF receptor-2 deficient (KO) mice. Here, mechanism of accelerated orthodontic tooth movement by micro-osteoperforations is introduced.

Biography

Dr Hideki Kitaura is an associate professor of Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry. The current research interest of Dr Kitaura is analysis of bone metabolism in orthodontic treatment of patients with lifestyle-related diseases, analysis of TNF-α-mediated osteoclast formation and bone resorption and study of accelerated orthodontic tooth movement. He supervised more than 20 PhD students and is supervising 7 PhD students and published more than 150 peer reviewed articles.

Dr Yu PAN
Dr Yu PAN

Topic

Occlusal Contact Trueness Affected by CAD/CAM Ceramic Materials

Abstract

The purpose of this self-controlled clinical study was to evaluate the trueness of occlusal contact affected by six ceramic materials during the chairside manufacturing process. Ten participants were selected for this study. InCoris TZl (ZIR), Celtra Duo (CD), IPS e.max (EMA), UPCERA LICI (LC), Vita enamic (ENA), UPCERA RUNCI (RC) were used to produce crowns for everyone by CEREC chairside CAD/CAM system. The milling trueness, postprocessing trueness and clinical adjustment of occlusal contact were quantitatively analysed by the ATOS high-precision scanner and Geomagic reverse engineering software. The results showed that milling trueness of ZIR was worst (p<0.05). Except for ENA, the postprocessing trueness of ZIR was significantly lower than the other four groups (p<0.05). As for clinical adjustment, all groups were adjusted. To be specific, ZIR was lower than CD and ENA. Six chairside ceramic blocks need to be designed with different negative occlusal offset to suite the material of the restoration for better manufacturing quality. ZIR required the least amount of compensation. Similar results can be obtained for LC and RC by applying the EMA and ENA CEREC chairside procedures respectively.

Biography

Dr Yu Pan (BDS, PhD) is an attending dentist and lecturer at the Department of Prosthodontics, School and Hospital of Stomatology, Fujian Medical University. She received a PhD degree of Prosthodontics from Fujian Medical University. Dr Pan is a youth committee of Chinese Specialty Committee on Prosthodontics and Dental materials. The current research interests of her are the accuracy of dental digital workflow and the biocompatibility of dental materials.

Dr Yifan LIN
Dr Yifan LIN

Topic

Orthodontics and Bone: Demystify their Relationship in Clinical Practice

Abstract

Orthodontics is inextricably linked to the bone. The homeostatic function of bone in a healthy periodontal environment is critical for successful orthodontic treatment. Numerous strategies have been developed to promote the growth, remodelling and regeneration of bone. Meanwhile, the mechanism of orthodontic tooth movement has been extensively studied. From the perspective of a clinical orthodontist, the presentation will provide an overview of the various bone biological processes that are relevant to clinical practice. Additionally, how orthodontists use orthodontic appliances to promote bone growth, remodelling, and regeneration, and ultimately achieve successful orthodontic treatment, will be discussed.

Biography

Dr Yifan LIN (BDS, SMD, PhD, MOrth RCSEd) has been a Clinical Assistant Professor and the Deputy Undergraduate Programme Director in Orthodontics at the Faculty of Dentistry, the University of Hong Kong, since 2019. She received a Doctor of Stomatological Medicine in Orthodontics from Peking University and a PhD degree from the University of Hong Kong. Dr Lin’s research interests include bone biology, periodontal regeneration, and management of cleft lip and palate.

Invited Lecture Series 4

Restorative Dentistry
Dr Tammy DUANGTHIP
Dr Tammy DUANGTHIP

Topic

A Paradigm Shift in Caries Management

Abstract

Tooth decay is a silent epidemic affecting more than two billion people worldwide. Underserved and vulnerable populations encounter persistent and systemic barriers to accessing restorative dental care. A paradigm shift in caries management using a non-restorative approach has been advocated. Studies have shown that silver diamine fluoride (SDF) is effective in arresting dental caries in primary teeth and root caries in elders. SDF can be a viable treatment alternative for caries control due to its simplicity to use, affordability, and accessibility. Recently, SDF has been added to the new section for dental preparations in the WHO Model List of Essential Medicines. This establishment is a crucial development to tackle the burden of dental caries and oral health inequalities. This lecture will discuss a paradigm shift in caries management focusing on SDF treatment for caries control. Clinical applications and indications of SDF use will be presented and discussed.

Biography

Dr Duangthip is a Senior Clinical Practitioner and Undergraduate Program Director in Cariology, The University of Hong Kong. She was conferred Doctor of Philosophy (PhD) and Master of Science in Community Dentistry from the University of Hong Kong, and Doctor of Dentistry (Dr med. dent.) from University of Bern, Switzerland, and Doctor of Dental Surgery (DDS) from Chulalongkorn University, Thailand. She is a Fellow of the Royal College of Dental Surgeons of Thailand (FRCDT) and a Member of the Royal Australasian College of Dental Surgeons (MRACDS) in Dental Public Health. She was an invited speaker in several international conferences such as World Congress on Preventive Dentistry and the South East Asia Association for Dental Education (SEAADE). Dr Duangthip presented her research at many international conferences and published more than 55 peer-reviewed journals, including the first author in Journal of Dental Research with H-index 18 and more than 1,000 citations (Scopus). Her research interest focuses on caries management and community dental care. Currently, she is an Associate Editor in BMC Oral Health and Assistant Specialty Chief Editor in Frontiers in Oral Health. Last but not least, Dr Duangthip is a Vice President of the Pediatric Oral Health Research Group of the International Association for Dental Research. She is also a Vice President of Society of Preventive Dentistry of Hong Kong.

Dr Qun LEI
Dr Qun LEI

Topic

Application of Comfort Therapy Concept in Dental Implantation

Abstract

"Comfortable treatment" is a more humanized medical method, which can greatly reduce the patient's nervousness and a series of physiological changes caused by fear. Application of comfort therapy in dental implantation can relieve patients' anxiety about dental examinations and surgery, improve patients' cooperation, and shorten the time for medical treatment. It enables the patient to complete the entire surgical procedure in a relatively comfortable and quiet state, improving patient satisfaction about the treatment.

Biography

Dr Qun Lei (DDS, MD, PhD) is an attending dentist and lecturer in dental implantation at school and hospital of Stomatology, Fujian Medical University. She is a member of the Oral Implantology Committee of the Chinese Stomatological Association.

Dr Nobuhiro YODA
Dr Nobuhiro YODA

Topic

Biomechanical and Mechanobiological Consideration for Dental Implant Treatments

Abstract

Recent digital workflow in dental implant treatment is remarkably updated. On the other hand, it is still difficult to make an implant treatment plan with prediction of future peri-implant bone changes after loading. Appropriate control of bone remodeling can contribute to the preservation and strengthening of peri-implant bone. Among several biomechanical and mechanobiological factors affecting the bone remodeling, the functional loading on implant can be a primary factor. Therefore, we have conducted the in vivo real-time measurement of functional load on implant. Also, we performed the patient-specific finite element analysis based on CT images and actual measured load data. This combined in vivo and in silico simulation studies enabled to establish the patient-specific peri-implant bone remodeling algorithm. This algorithm was further applied to the predictive simulation of future peri-implant bone changes, which can contribute to optimizing the implant prostheses and implant configuration, and also obtaining favorable long-term implant treatment outcome.

Biography

Dr Nobuhiro Yoda is Senior Assistant Professor at Division of Advanced Prosthetic Dentistry, Tohoku University Hospital in Japan. He received undergraduate training at Tohoku University School of Dentistry (DDS, 2003) and postgraduate education at Tohoku University Graduate School of Dentistry (Ph.D., 2007). He joined at Faculty of Engineering and Information Technologies at the University of Sydney as a visiting researcher from 2014 to 2016 and started some collaborative research regarding the dental biomechanics bone remodeling simulation. He has also been working at the Dental Implant Center in Tohoku University Hospital as a dentist and certificated as a Prosthodontic Specialist and a Dental Implant Specialist.

Meet a Professor

Tohoku University
Professor Guang HONG
Professor Guang HONG
MD, DDS, PhD

Biography

Prof Guang Hong is an Assistant Dean of Graduate School of Dentistry, Tohoku University, and the Professor and Chair of Division for Globalization Initiative. He is also the Director of Office of International Affairs at the Liaison Center for Innovative Dentistry. Prof Hong was conferred his PhD from the Hiroshima University Graduate School of Dentistry in 2003. Prof Hong is an executive board member of the Japanese Society for Dental Materials and Devices and an associate editor of the Dental Materials Journal. He serves as the Director of The Japan Denture Care Society. He is also a committee member of the International Standardization Accelerated Project Japanese Ministry of Economy, Trade and Industry and an expert of the International Organization for Standardization (ISO) and the German Institute for Standardization (DIN). Prof Hong’s research interest includes elucidation of the rheology properties of dental materials, the development of functionality of new dental materials and dental education. His research is mainly concerned with international standard institution; improvement and development of oral care and denture care materials, metal-free dental implant materials and development of dental materials and dental education system according to the Industry-Academia-Government collaboration. He published more than 80 papers with Science Journal Impact Factor. He received the Tohoku University Presidential Prize for Educational Excellence in 2019.

Professor Ken OSAKA
Professor Ken OSAKA
MD, MPH, PhD

Biography

Prof Ken Osaka is a professor at the Department of Community and International Health, Graduate School of Dentistry. His research interests include health inequality, association of oral health and other systemic disease and long-term care of the elderly. He is also a professor of the International Research Institute of Disaster Sciences (IRIDeS), the Smart Aging Research Organization (SARO) and the Tohoku Medical Megabank Organization (ToMMo). He is the senior researcher, Infectious Disease Surveillance Center, The National Institute of Infectious Diseases, Tokyo. Prof Osaka received his MMedSc and PhD from the Graduate School of Medicine, The University of Tokyo, Tokyo. He was a visiting researcher, Takemi Fellow, Department of International health and population Harvard School of Public Health. He worked in the Ministry of Health, Labor and Welfare, Tokyo as the Deputy Director, Division of the Health for the elderly. He was the person in charge of the revision of the law of the long-term care insurance of the elderly in Japan, introducing the program of the oral function improvement, physical activity improvement and nutritional consultation into the system.

Professor Masahiro SAITO
Professor Masahiro SAITO
DDS, PhD

Biography

Prof Masahiro Saito is the Vice-Chair of the Clinical Research Committee and the Vice-Director of the Clinical Research, Innovation and Education Center. He also serves as the Special Assistant of Hospital Director of the Tohoku University Hospital and the Vice-Director of Dental Division of the Tohoku University Hospital. Prof Saito received his DDS from the Kanagwa Dental College, Japan and PhD from the Kanagawa Dental College, Japan. Prof Saito started her career as an instructor at the Department of Operative Dentistry, the Kanagawa Dental College. He was a visiting fellow of the School of Medicine, Department of Pathology, University of Washington, USA. He then joined as an instructor at the Department of Operative Dentistry and Endodontics, Kanagawa Dental College and became an assistant Professor, Department of Operative Dentistry and Endodontics, Kanagawa Dental College. In 2006, Prof Saito joined as an assistant professor at the Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry. He was an associate professor, Faculty of Biological Science, Tokyo University of Science and a professor at the Division of Ecological Dentistry, Department of Restorative Dentistry, Tohoku University, Graduate School of Dentistry. He was the Chief of the Department of Endodontics, Tohoku University Hospital.

Meet a Professor

The University of Hong Kong
Professor Cynthia Kar Yung YIU
Professor Cynthia Kar Yung YIU
BDS, MDS, PhD, FHKAM, FCDSHK

Biography

Professor Cynthia Yiu is the Associate Dean in Clinical Affairs and a Clinical Professor in Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong. She received the Bachelor of Dental Surgery degree from King’s College, University of London, United Kingdom; and completed her Master of Dental Surgery degree in Paediatric Dentistry and Doctor of Philosophy degree from HKU. Prof Yiu is a Fellow of the Hong Kong Academy of Medicine in Dental Surgery and a Fellow of the College of Dental Surgeons of Hong Kong in the Specialty of Paediatric Dentistry. She joined the Faculty of Dentistry, The University of Hong Kong as a Clinical Dental Surgeon and became a Clinical Professor in 2012. She published about 230 journal articles and is the grant holder of many major research grants such as the RGC General Research Fund. She is also a key team member to receive a community service fund of US$7M from the HKJC Charity Trust to improve oral health of preschool children.

Professor Richard Yuxiong SU
Professor Richard Yuxiong SU
BMed, MMed, PhD

Biography

Professor Richard Yuxiong Su currently works as a Clinical Professor and Division Chief in Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong. He is the lead surgeon of maxillofacial oncology and microsurgical reconstruction team at the Department of Oral and Maxillofacial Surgery, Queen Mary Hospital, Hong Kong. He is also an Honorary Associate Professor at the Department of Otorhinolaryngology, Chinese University of Hong Kong. Prof Richard Su’s main research areas include clinical and translational research in Oral and Maxillofacial Oncology, microsurgical reconstruction, and salivary gland diseases. He published more than 100 manuscripts in peer-reviewed journals. He lectured extensively in regional and international conferences and courses. Prof Su is the inventor with seven patents, two were registered in the US and five in China. He received seven peer-reviewed external research grants as the principal investigator.

Meet a Professor

Fujian Medical University
Professor Bin SHI
Professor Bin SHI
BSc, MD, PhD

Biography

Professor Bin Shi is a clinical professor and an associate professor in the Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of the Fujian Medical University. His clinical work focus on comprehensive treatment of oral and maxillofacial tumors, reconstruction of oral and maxillofacial tissues and organs, orthognathic surgery, oral and maxillofacial trauma rehabilitation and oral implantation. His basic research focus on clinical application of digital imaging technology in Oral and Maxillofacial Surgery, and the correlation between implant surface morphology, osteogenesis and angiogenesis.

Professor Xiaojing HUANG
Professor Xiaojing HUANG
BSc, MD, PhD

Biography

Professor Xiaojing Huang is vice dean and professor (Endodontics and Restorative Dentistry) at the School and Hospital of Stomatology of Fujian Medical University. Her research interests are Microbiology and Cariology. She published over 70 publications and accomplished over 20 research projects, including 3 projects supported by the National Natural Science Foundation of China. She has been awarded Third prize of Science and Technology Progress of Fujian Province. Due to her outstanding achievements, she was awarded as “Young and Middle-Aged Experts” and “Returned Talents after studying abroad” by the Fujian Provincial Health Commission. As a well-recognized expert in her field, Prof Huang is in charge of national course “Endodontics” and involves in editing the national undergraduate teaching material “Endodontics”. She is appointed as the Vice Director of Geriatrics Dentistry Committee and an executive member of Laser Dentistry Committee in Chinese Stomatology Association. In addition, she is the Vice Director of Fujian Stomatology Association as well as the Director of Laser Dentistry Committee of Fujian Stomatology Association.

Young Scientist Invited Lectures

Dr Iris YIN
Dr Iris YIN

Topic

Use of Silver Nanoparticles in Caries Prevention

Abstract

Silver nanoparticles are wildly used as antimicrobial agents in dentistry. Their efficacy is not only due to their nanoscale size, but also to their large ratio of surface area to volume. Silver nanoparticles effectively inhibit cariogenic bacteria mainly Streptococcus mutans for caries management. They can be used as a topical antibacterial agent on enamel or dentin to prevent caries formation. The incorporation of silver nanoparticles into composite resin or glass ionomer cement can prevent secondary caries formation. Combined use of silver nanoparticles with diode laser irradiation (650 nm) or fluoride can remineralising carious lesion for caries prevention. Therefore, silver nanoparticles can be applied to teeth to prevent caries development. Silver nanoparticles has anti-bactericidal properties which can be incorporated into dental materials for prevention of secondary caries. Moreover, silver nanoparticles may be used to remineralise carious lesion and arrest caries. Although not all authorities have acknowledged the safety of silver nanoparticles, no systemic toxicity of ingested silver nanoparticles has been reported. This lecture provides an overview of application of silver nanoparticles in caries prevention, highlighting its antibacterial mechanism, potential applications and safety in clinical treatment.

Biography

Dr Iris Xiaoxue Yin is a clinical practitioner in the Faculty of Dentistry, The University of Hong Kong. She was conferred Bachelor of Medicine Stomatology from the Anhui Medical University and Doctor of Philosophy from The University of Hong Kong. Her research includes use of fluoride in caries management, dental lasers and in particular use of silver nanoparticles in dentistry. Dr Yin has published 20 international peer review journal articles in reputable journal such as Dental Materials and Journal of Dentistry. She received a handful of research and knowledge transfer awards including IADR Kulzer Travel Award in 2020 and Outstanding performance & commitment to community service award in 2021. She is review editor of specialty section of Frontiers in Oral Health.

Dr John Yun NIU
Dr John Yun NIU

Topic

Use of Antimicrobial Peptide for Dentistry

Abstract

During the past two decades, the use of antimicrobial peptides for dentistry has drawn considerable attention from researchers. Antimicrobial peptides are the first host defence line in response to microbial infection. In addition, they are involved in the innate immune response. Antimicrobial peptides kill microorganisms through direct binding with negatively charged microbial surfaces. Natural antimicrobial peptides play an essential role in oral health. Synthetic antimicrobial peptides are a potential alternative to traditional antimicrobial therapy. Pertinent to oral diseases, the deregulation of antimicrobial peptides is involved in the pathogenesis of dental caries, periodontal disease, mucosal disease, and oral cancer, where they can kill pathogenic microorganisms, promote tissue healing, serve as biomarkers and inhibit tumour cells.

Biography

Dr John Yun NIU is a research staff of the University of Hong Kong. He obtained his BDS and MDS from Wuhan University and PhD from Hong Kong University. He is a youth committee of the Temporomandibular Joint Diseases and Occlusion Scientific Committee of the Chinese Stomatological Association (CSA). He is a member of the International Association for Dental Research (IADR), the Chinese Stomatological Association (CSA), the Academy of Dental Materials (ADM), the World Federation of Laser in Dentistry (WFLD) and the Academy of Laser Dentistry (ALD). He is an Affiliate of the Royal Australasian College of Dental Surgeons (RACDS). Dr Niu was a clinical tutor at Shanxi Provincial People's Hospital, China.

Dr Senxin CAI
Dr Senxin CAI

Topic

Reducing Expression of SFRP3 and SFRP4 in TMJOA Model

Abstract

Mechanical stress overload in the temporomandibular joint (TMJ) is an important cause of TMJ osteoarthritis (TMJOA). Whether secreted frizzled-related protein (SFRP) 3 and SFRP4 play important roles in the development of mechanical stress-induced TMJOA remains controversial. In this study, we investigated the progression of mechanical stress-induced TMJOA using an in vivo model via modified increased occlusal vertical dimension (iOVD) malocclusion and an in vitro model in which isolated chondrocytes were subjected to mechanical stress. Our work suggests that mechanical stress reduces SFRP3 and SFRP4 expression both in vivo and in vitro and promotes TMJOA via Wnt/β-catenin signaling. Suppression of Wnt/β-catenin signaling promotes SFRPs expression, especially SFRP3 and SFRP4 expression, and rescues mechanical stress-induced cartilage degeneration. Wnt/β-catenin signaling and SFRPs may represent potential therapeutic targets for TMJOA.

Biography

Dr Senxin Cai is a resident orthodontist and working at the School and Hospital of Stomatology of Fujian Medical University. He is a member of the Oral Biomedical Professional Committee of the Chinese Stomatological Association and secretary of the Oral Biomedical Professional Committee of the Fujian Stomatological Association. Dr Cai's research interests include basic and clinical research in orthodontics and temporomandibular joint diseases, and he published about 5 articles in various journals.

Dr Venkata Venkataiah
Dr Venkata Venkataiah

Topic

Development of Osteoblast-scaffold Construct for Bone Regeneration Therapy

Abstract

This study aims to develop a new bone tissue engineering technology by combining mouse calvaria osteoblasts (MCOB) with 3-dimensional polylactic acid (3DPL) scaffold for large bone defects. Murine alveolar bone defect model is prepared by extraction of upper first molar and allowed to heal for four weeks. MCOB are isolated from mouse calvaria and seeded onto sterilized 3DPL scaffold to prepare MCOB-3DPL construct before transplantation. On the day of implantation, alveolar bone defect is prepared in the extraction site, filled with MCOB-3DPL construct, and left for 4 and 8 weeks. Commercial bone graft material (cytrans), 3DPL scaffold without cells and empty defect were used as control groups. Following implantation, the bone regeneration ability in the defect site is investigated by histological and micro-CT analysis. In addition, biomechanical properties of the regenerated bone tissue was investigated by nanoindentation tests and implant therapy. The Micro CT and histological analysis have confirmed that implanted MCOB-3DPL constructs have successfully regenerated bone within the mouse alveolar bone defects. Nanoindentation analysis has shown that MCOB-3DPL construct regenerated bone has similar micromechanical strength to the native bone. In addition, histological analysis following implant therapy revealed that regenerated bone possesses osseointegration ability, wherein a direct structural connection is established with the titanium implant surface. Tissue constructs formed by a 3DPL scaffold and immature osteoblast-like cells such as MCOBs represent a novel bone tissue engineering approach that enables the formation of vertical bone with the micromechanical properties suitable for regeneration of large bone defects.

Biography

Dr Venkata Suresh V is a recent PhD graduate from Tohoku University working on Tissue Engineering in Dentistry. In 2009, I graduated with a Bachelor of Dental Surgery (B.D.S.) in 2009 from K.G.F. College of Dental Sciences, India, and Master's in Dental surgery (M.D.S.) in 2014 from Vokkaligara Sangha Dental College and Hospital, India. Then worked as a Senior lecturer at the K.L.E. institute of dental sciences, India, focusing mainly on instructing and mentoring undergraduate students on operative dentistry and Endodontics. Presently, working as an assistant professor with a primary research focus on Bone tissue engineering. I aim to develop a tissue-engineered construct suitable for clinical applications. I am currently working to find out the best combination of cells and scaffolds with robust bone regeneration properties. In this regard, I am isolating osteogenic cells from bone biopsies and investigating their bone formation ability in in-vitro and in vivo studies. Our research findings show that these bone-derived cells possess a more remarkable osteogenic ability, enhancing bone regeneration. Currently, we utilize these osteogenic cells and combine them with various bio-scaffolds to identify the suitable cell-scaffold construct for further enhancing bone regeneration in small and large animal bone defect models. Apart from primary research, I am actively involved with co-researchers in their research work, which mainly focuses on molecular and cellular research activities related to endodontics, such as investigating target therapeutic molecules to treat apical periodontitis.

Dr Xiongcheng XU
Dr Xiongcheng XU

Topic

Nanosilicate-functionalized PCL Orchestrates Bone Regeneration

Abstract

Massive oral and maxillofacial bone defect regeneration remains a major clinical challenge due to the absence of functionalized bone grafts with ideal mechanical and pro-regeneration properties. Laponite (LAP) was incorporated into polycaprolactone (PCL) to develop a biomaterial for bone regeneration. A series LAP-embedded PCL composites were synthesized. Then we explored whether LAP-embedded PCL would accelerate bone regeneration by orchestrating osteoblasts to directly and indirectly induce bone regeneration processes in vitro and in vivo. The results confirmed the presence of LAP in PCL, and LAP was distributed in the exfoliated structure without aggregates. Incorporation of LAP in PCL slightly improved the compressive properties. LAP-embedded PCL is biocompatible and exerts pronounced enhancements in cell viability, osteogenic differentiation and extracellular matrix formation of osteoblasts. Furthermore, osteoblasts cultured on LAP-embedded PCL facilitated angiogenesis of vessel endothelial cells and alleviated osteoclastogenesis of osteoclasts in a paracrine manner. The addition of LAP to the PCL endowed favorable bone formation in vivo. LAP-embedded PCL shows great potential as an ideal bone graft that exerts both space-maintaining and vascularized bone regeneration synergistic effects and can be envisioned for oral and maxillofacial bone defect regeneration.

Biography

Dr Xiongcheng Xu currently works at School and Hospital of Stomatology, Fujian Medical University. He received his DDS and PhD from Fujian Medical University, China. Dr Xu is the recipient of Excellent Postgraduate Dissertation Awards of Fujian Province in 2018. He has published 6 peer-reviewed scientific articles. Dr Xu’s research focuses on periodontology in attempts to regenerate various periodontal defects.

Dr Taro Kusama
Dr Taro Kusama

Topic

Elucidating the Mechanisms between Oral and Systemic Health

Abstract

Objectives: The present study aimed to investigate the mediating effect of weight loss in the relationship between tooth loss and increased mortality risk.

Methods: This was a 10-year follow-up prospective cohort study targeting independent older adults aged 65 years or older at baseline and were followed up from 2010 to 2020. The incidence of death between 2013 and 2020, incidence of >5% weight loss in 2010 and 2013, and the number of remaining teeth in 2010 were used as the outcome, mediator, and explanatory variable, respectively. We conducted the causal mediation analysis using Cox proportional hazard model. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) of total effect (TE), natural indirect effect (NIE), and proportion mediated (PM) were estimated, respectively.

Results: Among the 34,510 participants, the mean age was 72.6 (SD =5.4), and 47.6% were men. From 2013 to 2020, 14.0% of the participants (n=4,825) died, 60.5% (n=20,871) had 0–19 remaining teeth in 2010, and 17.2% (n=5,927) experienced >5% weight loss from 2010 to 2013. The mortality rate was 0.016 per person-year among those with ≥20 remaining teeth and 0.027 per person-year among those with 0–19 remaining teeth. Weight loss of 5% significantly mediated the association between tooth loss and higher mortality risk (TE: HR, 1.27 [95%CI, 1.16 to 1.39]; NIE: HR, 1.02 [95%CI, 1.02 to 1.03]; PM, 11.1%).

Conclusion: The present study suggested that weight loss is one of the possible mechanisms linking oral and systemic health among older adults.

Biography

Dr Taro Kusama is an assistant professor at the Division of Regional Community Development of the Liaison Center for Innovative Dentistry, Tohoku University Graduate School of Dentistry. He obtained his DDS from the Tohoku University School of Dentistry in 2016, and obtained his PhD from the Tohoku University Graduate School of Dentistry in 2021.