Professor Richard SU

Title

Computer-assisted Jaw Reconstruction: from 3D Printing to Artificial Intelligence

Abstract

The maxilla and mandible provide skeletal support for the middle and lower third of our faces, thus playing a crucial role in maintaining the upper airway, chewing, swallowing and speech. Reconstruction of jaw is often mandatory after segmental resection to restore proper facial esthetics and function. Microvascular bone flap reconstruction has gained its popularity in jaw reconstruction in the recent years due to its consistent shape, ample length, low donor-site morbidity, and allowing osseointegrated dental implants for masticatory function rehabilitation. The past few years has witnessed the great advancement in computer-assisted jaw reconstruction. Preoperative virtual surgical planning increased the proficiency and predictability of jaw reconstruction. The application of three-dimensional (3D)-printed surgical guides and patient specific surgical plates further improved the accuracy of free flap reconstruction. In this presentation, I will discuss our digital workflow of computer-assisted maxillary and mandibular reconstruction based on virtual surgical planning and 3D printing. And most recently, we developed artificial intelligence-enabled computer-assisted jaw reconstruction, which further streamlined the surgical process and improved treatment outcome.

Biography

Professor Richard Yuxiong Su currently works as Clinical Professor and Chief of Division of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong. He is also an Honorary Professor at the Department of Otorhinolaryngology, Chinese University of Hong Kong. Professor Su is a Councillor of International Academy of Oral Oncology. He serves as international faculty and Asia Pacific Board member of the AO Craniomaxillofacial Foundation. He also works as a Section Editor of International Journal of Oral and Maxillofacial Surgery, an Associate Editor of Frontiers in Oncology (Head and Neck Cancer Section) and Deputy Editor of Craniomaxillofacial Trauma & Reconstruction. His main research areas include clinical and translational research in oral and maxillofacial oncology, microsurgical reconstruction, and salivary gland diseases, with special focus on computer-assisted surgery and 3D printing in head and neck reconstruction. He has published more than 150 manuscripts in peer-reviewed international journals. Professor Su is the inventor of seven patents, including two US and EU patents and five China patents. He has been awarded ten peer-reviewed external research grants as the principal investigator. Professor Su has been invited to give lectures in numerous international and regional conferences and courses. He is ranked by Clarivate Analytics in the top 1% researcher worldwide by citations in 2021 and 2022.

Professor John Junwen WANG

Title

Application of Bioinformatics and Artificial Intelligence in Precision Oral Cancer Research

Abstract

The advances of next generation sequencing (NGS) and artificial intelligence (AI) are revolutionize biology and medicine. Precision dentistry is an emerging area in dentistry that utilizes personalized genomic, diet information and life habit to guide diagnosis, treatment and prognosis of dental diseases. I will introduce several recent works from my lab on utilizing genomics and AI tools to deepen biological understanding and to enhance patient care. Firstly, I will introduce how we are using genomics, transcriptomics and proteomics data to detect genes, pathways and signatures that are key to the pathogenesis of hypopharynx cancer in multiple cohorts of Chinese patients. Secondly, we are building a data portal of oral cancers that integrates over gene expression and clinical data from over 40 studies. Users can carry out analysis such as differentially expressed gene, pathway enrichment, survival analysis on the portal. Thirdly, I will report our findings on how AlphaFold performs on predicting functions of pathogenic variants and some surprise observations. Finally, we are developing a deep learning model to integrate single cell multi-omics data from Neat-seq technology and to infer gene regulatory networks. These bioinformatics and AI methods will contribute to not only oral cancer, but other dental disease areas.

Biography

Professor Wang is currently a professor in Faculty of Dentistry, the University of Hong Kong (HKU). He was a full Professor of Biomedical Informatics at Mayo Clinic in Arizona, and affiliate Professor at Arizona State University, USA. He obtained his PhD from University of Washington, Masters from University of Pennsylvania, USA and Jiangnan University, and BE from Huazhong Agricultural University, China. Prof. Wang’s research interests are in Bioinformatics, gene regulatory network construction, AI and methodology development for data analysis. He has published over 130 papers in journals such as Nature genetics, Nature Communications, Nature Machine Intelligence, Circulation, NAR, Bioinformatics, and has obtained funding from RGC of Hong Kong, and NIH of USA as project leaders. He was an ISI top 1% cited scholar, an outstanding young researcher awardee at HKU, and is currently an associate editor of Journal of Cancer Immunology, Immunotherapy.

Professor Lijian JIN

Biography

Professor Jin is the Acting Dean, Modern Dental Laboratory Professor in Clinical Dental Science and Professor of Periodontology at the HKU Faculty of Dentistry. He joined HKU in 1994 and was the Associate Deans for Mainland & Global Affairs (2006-2010) and Research, Innovation & Enterprise (2011-2015). He was honored with the Fellowship in Dental Surgery ad hominem by the Royal College of Surgeons of Edinburgh (2007). His main leadership services include the Councilor of FDI World Dental Federation in Geneva (2015-2021), Chair of FDI Global Periodontal Health Project Task Team (2016-2021) and FDI Science Committee Chairman (2012-2015); Member of IADR Board of Directors (2018-2021), President of IADR-Asia Pacific Region (2019.12-2020) and Chair of IADR-Task Group in Periodontal Disease - GOHIRA (2009-2012); Past-president of Asian Pacific Society of Periodontology (2011-2013); Founding Member of Specialty Board in Periodontology of the College of Dental Surgeons of Hong Kong (2001-2017); and a current Board Member of International Academy of Periodontology (2012-). He is the editorial board member of J Clin Periodontol (2011-) and J Periodont Res (2007-), and sat on the editorial boards of J Periodontol (2006-2023) and JDR (2010-2015). He has contributed to organizing various international conferences like FDI World Oral Health Forum (2017) and Asian Pacific Dental Congress (2004/2009/2016). He has received 10 GRF grants from the Hong Kong Research Grants Council, and his team has obtained multiple international prizes. Professor Jin has primarily supervised research projects for over 40 postgraduates, delivered more than 230 invited lectures nationally/internationally, and published 282 journal papers/book chapters.

Professor Chun Hung CHU

Biography

Professor Chu is a Chair Professor and Associate Dean of the Faculty of Dentistry at The University of Hong Kong (HKU). Professor Chu is a member of the FDI World Dental Federation Public Health Committee (2021-2024) and the Vice President of the Asian-Oceanian Federation of Conservative Dentistry (2023-2025). Professor Chu received BDS, PDipDS, MDS, and PhD from HKU. He is a dental fellow of the Hong Kong Academy of Medicine, and a registered specialist in Family Dentistry in Hong Kong. He is a Master of the Academy of General Dentistry (AGD) and received the prestigious AGD Lifelong Learning & Service Recognition Award. Through overseas examinations, Professor Chu became a fellow of the Royal Australasian College of Dental Surgeons (RACDS) in Sydney, Australia; a dental fellow of the Royal College of Surgeons (RCSEd) in Edinburgh, United Kingdom; and a diplomate of the American Board of General Dentistry in Chicago, United States. He is a dental examiner of the RCSEd and a member of the RACDS specialist board in Dental Public Bealth. Professor Chu was elected as a fellow of the RCSEd Faculty of Dental Trainers for his eminence in clinical teaching, a fellow of the Academy of Dental Materials for his excellence in innovative research, and a fellow of the International College of Dentists for his dedication to community services. Professor Chu has published extensively with an h-index of 49 (Scopus). He is the chief editor of the section on Preventive Dentistry in both Frontiers in Oral Health and the Dentistry Journal. He is an editor of the International Dental Journal, JDR Clinical & Translational Research, the Journal of Dental Research, and BMC Oral Health. Professor Chu received plenty of grants for research and community services. He teaches restorative dentistry for dental students, supervises research for PhD students and post-doctoral fellows.

Professor Edward LO

Biography

Professor Edward C.M. Lo is currently Chair Professor of Dental Public Health in the Faculty of Dentistry in the University of Hong Kong. He has obtained full academic and specialist training in Hong Kong, including BDS, MDS and PhD degrees, and Fellowship of the Hong Kong Academy of Medicine (FHKAM). He had served as a guest/visiting professor in a number of major dental schools in China. He is a past President of the International Association of Dental Research (IADR) Asia-Pacific Region, and a past IADR Treasurer. His research interest is in oral epidemiology, oral healthcare services and preventive dentistry. He has published over 350 papers in international scientific journals and a few book chapters. Professor Lo has conducted many oral epidemiological surveys on various population groups. He has also conducted many laboratory and clinical studies on new preventive and treatment methods for dental caries. Professor Lo has published extensively on clinical trials using various topical fluoride agents in the prevention of dental caries, and the use of various agents to arrest active decay in the primary teeth of young children and root caries in older adults. With his outstanding contributions to the field, Professor Lo was awarded the IADR Distinguished Scientist Award in Geriatric Oral Research in 2016 and also the IADR E.W. Borrow Memorial Award (for research in oral health promotion for children) in 2021.

Professor James TSOI

Biography

Professor James Tsoi is an Associate Professor in Dental Materials Science and Assistant Dean (Innovation) at HKU Faculty of Dentistry. He received BSc in Applied and Analytical Chemistry and PhD in Dental Materials Science, from the University of Hong Kong. He also holds the Memberships of Royal Society of Chemistry (MRSC) and British Computer Society (MBCS), and Fellow in Advanced HE (FHEA). James is actively engaged in a number of research areas including: Dental materials science (mechanical behaviours, surface/bonding and ceramics), smart manufacturing (CAD/CAM and 3D printing), digital dentistry (AI and data science) and dental education (basic science and e-learning). He has authored more than 130 peer-reviewed journal articles, published and granted 10 patents, graduated 36 MSc and 11 PhDs, and been awarded 8 times in international conferences since he joined HKU Dentistry as a faculty member in 2012. He is currently serving several SCI journals’ editorial board (including Dental Materials), being President-elect in IADR-Dental Materials Group, Member-at-large in the Academy of Dental Materials, and Hong Kong head-of-delegate in ISO/TC 106 (Dentistry).

Professor May Wong

Biography

Professor May CM Wong is a Professor in Dental Public Health at the Faculty of Dentistry, The University of Hong Kong (HKU). She is the Director of the Clinical Research Centre at the faculty. She teaches courses on biostatistics and clinical research methods to graduate and undergraduate students. Professor Wong has contributed to the research community as an editor of the Cochrane Oral Health Group, Associate Editor of Community Dentistry and Oral Epidemiology, and Statistical Consultant for Clinical Oral Implants Research. Her leadership positions within the International Association of Dental, Oral, and Craniofacial Research (IADR) include President of the Southeast Asian Division, Board of Directors of the Asian Pacific Region, and President of the Evidence-based Dentistry Network. Her research focuses on biostatistics, clinical trials, oral epidemiology, oral health promotion, and quality of life. She has been involved in nearly 30 funded research projects as the principal investigator or co-investigator and published over 130 international peer-reviewed papers. Her research contributions have been acknowledged through awards received at HKU, international conferences and from journals. Professor Wong has received the prestigious 2021 IADR Distinguished Scientist H. Trendley Dean Memorial Award. This award recognizes investigators with meritorious research in epidemiology and public health and is considered one of the highest honors bestowed by IADR.

Professor Cynthia YIU

Biography

Professor Cynthia Yiu is a Chair Professor in Paediatric Dentistry, Associate Dean in Clinical Affairs and Postgraduate Programme Director in Paediatric Dentistry at the Faculty of Dentistry, the University of Hong Kong (HKU). Additionally, Prof Yiu is the Director of the Prince Philip Dental Hospital in Hong Kong. She obtained her Bachelor of Dental Surgery degree from King’s College, University of London and completed her Master of Dental Surgery (MDS) degree in Paediatric Dentistry as well as Doctor of Philosophy (PhD) degree from HKU. Prof Yiu is a Fellow of the Hong Kong Academy of Medicine (Dental Surgery), the College of Dental Surgeons of Hong Kong (Paediatric Dentistry) and the International College of Dentists. In 2011 and 2013, she received the “Faculty Outstanding Teacher Award” and “Outstanding Team-Teaching Award” from HKU, respectively. She has supervised over 10 PhD students and 30 MDS students. Currently, she serves on the Editorial Board of Journal of Dentistry, International Dental Journal and BMC Oral Health. Her research focuses on adhesive dentistry, cariology and paediatric oral health. Prof Yiu’s research team has received several research awards at the annual meetings of International Association for Dental Research (IADR) and International Association of Paediatric Dentistry (IAPD). She was a member of the Fellowships Committee of IADR from 2021 to 2023 and served as the Chairman from 2023 to 2024. Prof Yiu has published over 250 journal papers and book chapters, with a focus on prevention of dental caries and improvement of the durability of adhesive restorations.

Professor Chengfei ZHANG

Biography

Professor Chengfei Zhang is a clinical professor in Endodontics, Associate Dean for Research and Innovation, Faculty of Dentistry, The University of Hong Kong (HKU). He serves as an editorial board member for International Endodontic Journal, International Dental Journal, and Bioengineering. He obtained his DDS and his Ph.D. degree from Peking University. He joined the Faculty of Dentistry HKU in 2009. His innovative research activities are internationally recognized, and he was awarded the IADR William J Gies Award for Biomaterials and Bioengineering Research, the Journal of Endodontics award for best paper, and the IADR distinguished scientist. His research in endodontic etiopathogenesis and pulp regeneration has been funded by Hong Kong RGC and Chinese mainland funding. He has lectured on many occasions nationally and internationally, particularly in IADR/ AADR and IADR-SEA meetings, and published over 200 journal papers/ book chapters.

Professor Alice CHAN

Title

Common medical and dental problems in older adults

Abstract

Population is ageing. The older adult population is growing in number and proportion worldwide. There will be 1.6 billion of older adults aged 65 or above, consisting 1 in 6 of our population by 2050. Ages changes, chronic medical conditions and polypharmacy make older adults more vulnerable to oral diseases; numerous evidence showed that oral health was associated with general health and overall well-being of older adults. World Health Organization and FDI World Dental Federation acknowledged oral health as a crucial factor in healthy ageing. With the increasing demand in oral health care in older adults, oral health care professionals should be equipped with knowledge and skill in geriatric oral care. They should understand the interlaced oral and systemic health in order to provide a personalized, comprehensive and integrated care plan for older adults. This presentation will give you an overview of the common medical and dental problems and their impacts in older adults.

Biography

Professor Chan is the Clinical Assistant Professor in Restorative Dental Sciences of the Faculty of Dentistry, The University of Hong Kong (HKU). She received her postgraduate and specialist training in prosthodontics in the University of Hong Kong and is a registered prosthodontist in Hong Kong. She is a fellow of the Royal College of Surgeons of Edinburg, the College of Dental Surgeons in Hong Kong and the Hong Kong Academy of Medicine. Dr Chan practiced in dentistry for 15 years before she became an academics. Her research interest is oral health care in older adults. She has published 18 scientific articles in international peer-reviewed journals. She has received four awards in international conferences including the Outstanding Research Award in the 15th International Conference of the Asian Academy of Preventive Dentistry, the 3rd prize of poster presentation in the 2nd General Meeting of Asian-Oceanian Federation of Conservative Dentistry, the Best poster award in the 2022 TU-HKU-FJMU International Symposium Oral Health Sciences and the Most popular poster award in the 11th Hong Kong International Dental Expo and Symposium 2022. She serves as a journal editor in Frontiers in Oral Health and journal reviewers in several journals including Journal of Dentistry and Caries Research.

Dr Chris FOK

Title

Dissecting the latest periodontal classification and its implications

Abstract

Severe periodontal disease is a global health concern, affecting 10-15% of the population. The implications of this are far-reaching, as the mismanagement and misdiagnosis of periodontal disease are on the rise, leading to devastating consequences for both patients and clinicians. The failure to diagnose by taking adequate radiographs to assess bone levels, evidence of risk assessment, monitoring, or treatment of the disease is a major issue in dentistry. In 2017, the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP) co-presented the new classification for periodontal and peri-implant diseases and conditions at the world workshop. This workshop aims to achieve the following:

• Identify the main categories of the New Periodontal Classification.
• Understand the characteristics of the periodontal conditions in the new Periodontal Classification.
• Understand the diagnosis of periodontal disease using the staging & grading system.
• Understand the benefits of the new periodontal diagnostics and compare them with the previous ones.
• Use case series as examples to facilitate and practice the new diagnosis in praxis.
• Discuss possible limitations and challenges when it comes to the new classification.

Biography

Dr Chris Fok graduated in 2015 from the University of Hong Kong with a bachelor’s degree in dentistry. In 2020, he was awarded the Master of Dental Surgery in Periodontology with distinction by the University of Hong Kong under the guidance of the team led by Professor Maurizio Tonetti. He obtained the Certificate of Completion of Specialized Training in Periodontology and Implant Dentistry from the European Federation of Periodontology (EFP) and was the first graduate of the first EFP-accredited programme in Asia. He was awarded the Membership in Periodontics from the Royal College of Surgeons of Edinburgh and from the College of Dental Surgeons of Hong Kong. In addition to private practice limited to periodontology and implant dentistry, he has been active in undergraduate and postgraduate training in the University of Hong Kong. He is interested in research in periodontal medicine, masticatory function and dietary quality in periodontitis patients. He is currently leading, together with Prof. George Pelekos, a clinical trial on the periodontal therapy and rehabilitation of stage IV periodontitis patients under the Azalea (1972) Endowment Fund.

Professor Phoebe LAM

Title

Effective Strategies for Managing Children with Autism Spectrum Disorder in the Dental Setting

Abstract

The prevalence of Autism Spectrum Disorder (ASD) has experienced a notable surge among children, necessitating the development of customised management strategies by dental professionals. This workshop will deliver informative lectures covering the general profile of ASD, including its causes, as well as the distinct medical and dental challenges associated with the condition. Additionally, the workshop will delve into effective strategies for behavioural dental management tailored made for autistic children. Through case showcases and interactive discussions, participants will have the opportunity to explore real-life scenarios and exchange valuable insights. Expert speakers will share practical techniques for managing the behavioural challenges commonly encountered during dental treatments for children with ASD. The workshop will conclude with a summary of key take-home messages and provide practical tips for dental professionals to effectively manage the dental care of autistic children and support their families. By the end of the workshop, participants will gain a comprehensive understanding of ASD and acquire enhanced skills in behavioural management techniques. This workshop aims to equip dental professionals with the necessary knowledge and skills to deliver optimal dental care for children with ASD, while effectively supporting their families.

Biography

Professor Phoebe Lam is a Clinical Assistant Professor in Paediatric Dentistry at the University of Hong Kong. She completed her specialist training in Paediatric Dentistry in Hong Kong and and is recognised as a Fellow in the Hong Kong College of Dental Surgeons. With membership in Paediatric Dentistry from the Royal College of Surgeons of Edinburgh, Prof Lam is a well-trained clinician in this field. Prof Lam holds a PhD from the University of Hong Kong and is actively engaged in research focused on paediatric dentistry, caries prevention among children, and dental care for individuals with special needs. Her research findings have been published in esteemed medical and dental scientific journals, such as Autism, J Evid Based Dent Pract, J Nutr Health Aging, Caries Res, and Int J Paed Dent. In addition to her academic pursuits, Prof Lam is dedicated to promoting oral health among underprivileged populations and individuals with special needs. She has been actively involved in leading and organising dental outreach and service campaigns in Hong Kong and various developing countries. Her team's efforts have been recognised with numerous awards, including 7 HKU SERVICE 100 Fund grants, 4 Gallant Ho Experiential Learning Funds, the Stephen H Y Wei Award in Paediatric Dentistry 2016, HKU KE Impact Project Funding, HKU Knowledge Exchange Excellence Award 2015, and others for their impactful service projects in Hong Kong, Mainland China, Cambodia, Uganda, Togo, and Tanzania.

Professor Xin LI

Title

Gelatinolytic activity in dentin upon adhesive treatment

Abstract

In this multi-parameter study, we aimed to explore the effect of diverse factors related to dental adhesive application on the activation of host-derived gelatinases. The presence of gelatinases in dentin powder upon contact with two gold-standard adhesives Optibond FL (Kerr) and Clearfil SE Bond 2 (Kuraray Noritake) was assessed by gelatin zymography. Gelatinolytic activity along adhesive-dentin interfaces was imaged using in-situ zymography. Changes in MMP-2/9 activity upon interaction with adhesives, 37°C incubation, and temperature increase during light-curing of adhesives were evaluated by a high-throughput DQ-gelatin assay. Furthermore, the adhesive-dentin interfaces were challenged with 0.01-µM MMP-9 for 1-m, upon which the micro-tensile bond-strength (µTBS) was measured. Gelatinases were detected in phosphoric acid-etched dentin powder, while the two adhesives generated no measurable MMP activation. In-situ zymography revealed that the gelatinolytic activity from specimens treated with two adhesives appeared similar as that of EDTA negative control. In solution, MMP-2/9 activity significantly decreased upon interaction with both adhesives; gelatinases were almost completely deactivated upon 1-w incubation at 37°C; light-curing increased temperature to 70°C, which appeared sufficient to dramatically decrease MMP-2/9 activity. Finally, challenging adhesive-dentin interfaces did not significantly affect µTBS. The two adhesives did not activate the release and activation of dentinal gelatinases.

Biography

Professor Li Xin is a clinical assistant professor in Endodontics at the Faculty of Dentistry, the University of Hong Kong. She received the Bachelor’s degree in Dentistry and Master’s degree in Endodontics from Wuhan University in China. She also obtained a PhD degree in Biomedical Sciences and a second Master’s degree in General Dentistry at KU Leuven in Belgium. Her research interest includes dental restorative biomaterials, for instance hydraulic calcium silicate cements and resin-modified biosafe and bioactive composites. She is also a licensed dentist in Europe, and she is motivated to integrate the latest scientific evidence into healthcare so to ensure a high-quality evidence-base dental practice.

Professor George PELEKOS

Title

Dissecting the latest periodontal classification and its implications

Abstract

Severe periodontal disease is a global health concern, affecting 10-15% of the population. The implications of this are far-reaching, as the mismanagement and misdiagnosis of periodontal disease are on the rise, leading to devastating consequences for both patients and clinicians. The failure to diagnose by taking adequate radiographs to assess bone levels, evidence of risk assessment, monitoring, or treatment of the disease is a major issue in dentistry. In 2017, the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP) co-presented the new classification for periodontal and peri-implant diseases and conditions at the world workshop. This workshop aims to achieve the following:

• Identify the main categories of the New Periodontal Classification.
• Understand the characteristics of the periodontal conditions in the new Periodontal Classification.
• Understand the diagnosis of periodontal disease using the staging & grading system.
• Understand the benefits of the new periodontal diagnostics and compare them with the previous ones.
• Use case series as examples to facilitate and practice the new diagnosis in praxis.
• Discuss possible limitations and challenges when it comes to the new classification.

Biography

Professor Pelekos completed his specialist training in periodontics and implant dentistry at the Eastman Dental Institute, University College London (UCL), UK 2009, and then joined HKU Faculty of Dentistry as a Clinical Assistant Professor in 2014. He completed his PhD in 2020 from Tohoku University (JPN). He is an established clinician, educator and researcher. Professor Pelekos is the Postgraduate Programme Director in Periodontology (MDS) and Implant Dentistry (MSc). Importantly, the MDS Programme in Periodontology was accredited by the world leading organization in periodontology – the European Federation of Periodontology (EFP) in 2019 (the 1st program accredited by EFP outside Europe). In addition, he holds a Fellowship at the Royal College of Physicians & Surgeons of Glasgow, UK, and serves as a Trainer for the Periodontology Specialty at the College of Dental Surgeons of Hong Kong. Professor George’s academic career focuses on Periodontology and Implant Dentistry. His philosophy is that Periodontology is a fusion of biology, dental medicine, microbiology, immunology and behavioural science. This is reflected in his teaching, research and clinical practice. Indeed, Periodontology is his natural "habitat" at HKU, and his goal is to enhance the healthcare standard of tomorrow's periodontal specialists and general dentists and make notable contributions to the science and practice of Periodontology and Implant Dentistry. Professor Pelekos has published extensively in peer reviewed journals and has been invited to the editorial board member of the leading journal in his specialty - Journal of Clinical Periodontology. He has long served as an expert reviewer for the major scientific journals in Periodontology, Implant Dentistry and Medical/Dental Education since 2013.

Professor Simin PENG

Title

Effective Strategies for Managing Children with Autism Spectrum Disorder in the Dental Setting

Abstract

The prevalence of Autism Spectrum Disorder (ASD) has experienced a notable surge among children, necessitating the development of customised management strategies by dental professionals. This workshop will deliver informative lectures covering the general profile of ASD, including its causes, as well as the distinct medical and dental challenges associated with the condition. Additionally, the workshop will delve into effective strategies for behavioural dental management tailored made for autistic children. Through case showcases and interactive discussions, participants will have the opportunity to explore real-life scenarios and exchange valuable insights. Expert speakers will share practical techniques for managing the behavioural challenges commonly encountered during dental treatments for children with ASD. The workshop will conclude with a summary of key take-home messages and provide practical tips for dental professionals to effectively manage the dental care of autistic children and support their families. By the end of the workshop, participants will gain a comprehensive understanding of ASD and acquire enhanced skills in behavioural management techniques. This workshop aims to equip dental professionals with the necessary knowledge and skills to deliver optimal dental care for children with ASD, while effectively supporting their families.

Biography

Professor Simin Peng is a Clinical Assistant Professor in Paediatric Dentistry at the Faculty of Dentistry, The University of Hong Kong. She holds a Bachelor of Medicine (BMed) and a Master of Medicine (MMed) in Stomatology from Guanghua School of Stomatology, Sun Yat-sen University. She also completed her Doctor of Philosophy (PhD) degree at HKU. Prof Peng's clinical, teaching, and research journey in Paediatric Dentistry began at the Guanghua School of Stomatology, Sun Yat-sen University. She has extensive teaching experience in undergraduate and postgraduate education and has actively participated in dental education programs. Prof Peng is a Fellow of the Higher Education Academy (FHEA) in the UK. Her research interests include oral diseases in Paediatric Dentistry, dental education, epidemiology of oral diseases, dental health and nutrition status, and dental pain. She has published research papers in international scientific journals and serves as an invited reviewer for various scholarly journals. Prof Peng's research team has received awards at the annual meetings of the International Association for Dental Research (IADR) and the Southeast Asia Association for Dental Education (SEAADE).

Professor Zhiyi SHAN

Title

Leveraging Artificial Intelligence to Transform Orthodontics

Abstract

The emergence of artificial intelligence (AI) as a transformative force in various fields has prompted significant advancements in orthodontics. This talk delves into the current applications of AI in orthodontics, focusing on three key areas: diagnostics, treatment planning, and clinical practice. AI's role in boosting diagnostic precision and efficiency lays the foundation for personalized treatment plans tailored to individual patients. Treatment planning benefits from AI's capacity to analyse extensive datasets, allowing orthodontists to make well-informed decisions for enhanced patient outcomes. Moreover, AI-driven systems have revolutionized clinical operations through optimized practice management, seamless remote care, and streamlined documentation. However, realizing AI's full potential in orthodontics requires overcoming challenges such as data privacy concerns, algorithmic biases, and fostering interdisciplinary collaboration. This talk underscores the importance of staying abreast of AI's applications, challenges, and prospects to harness its transformative power and elevate patient care in orthodontics.

Biography

Professor Shan holds the position of Clinical Assistant Professor in Orthodontics at the Faculty of Dentistry, The University of Hong Kong (HKU), where she actively engages in undergraduate and postgraduate education, clinical and basic research, and clinical orthodontic practices. She was granted the Hong Kong Postgraduate Fellowship (HKPF) and earned her PhD from HKU. Prior to this, she completed her BDS and MDS training in orthodontics at Shanghai Jiao Tong University, where she was recognized as an Outstanding Graduate Student. As a licensed practitioner in both Hong Kong and mainland China, Dr. Shan has gained substantial practical experience. With nine years in orthodontic practice, she has developed skills in various orthodontic techniques, including fixed appliances, clear aligners, and lingual appliances. Dr. Shan's research interests encompass CAD/CAM appliances, dentofacial 3D simulation, and orthodontic-periodontal interdisciplinary treatment. Her contributions to the field have been acknowledged through the publication of fourteen articles in reputable journals. She was also awarded the CTOR Award for Student Excellence in Orthodontic Research in 2021 and listed as a finalist for the same award in 2022. Furthermore, Dr. Shan is serving as an invited reviewer for ten SCI journals. Dr. Shan is dedicated to advancing orthodontic knowledge through her efforts in clinical practice, research, and education, and she values the opportunity to contribute to the dental and orthodontic community.

Dr Iris Xiaoxue YIN

Title

The application of graphene materials for dental use

Abstract

Graphene is a nanomaterial made up of carbon atoms arranged in a two-dimensional structure. Graphene materials possess advantageous physicochemical, mechanical, and morphological characteristics that can be used in biomedical applications. Some graphene materials, such as graphene oxide, contain various reactive oxygenic groups, such as carbonyl and carboxyl groups on the edges and hydroxyl and epoxide groups on the planes, which can strengthen the interaction of components at the interface. They are used in many biotechnologies because of their large surface area, simplicity of chemical functionalization, favourable biocompatibility, and biostability. Graphene materials can be activated and functionalised with metal and metal nanoparticles, polymers, and other small molecules to exhibit multi-differentiation activities, antimicrobial activities, and biocompatibility. They underwent investigations in the fields of preventative dentistry and regenerative dentistry. They have the ability to hinder the growth of cariogenic bacteria and periodontal bacteria. Graphene families can enhance the process of mineralization on both enamel and dentine. These materials have been extensively researched in the field of regenerative dentistry research, namely in the areas of dental hard and soft tissue regeneration, as well as periodontal tissue and bone regeneration. The aim of this talk is to provide an overview of the application of graphene materials for dental use.

Biography

Dr Iris Xiaoxue Yin is clinical practitioner in the Faculty of Dentistry at the University of Hong Kong. She was conferred Bachelor of Medicine Stomatology from the Anhui Medical University and Doctor of Philosophy from The University of Hong Kong. She specializes in the field of developing and accessing biomaterials for minimum intervention in caries management. She published 33 articles in international peer-reviewed journal and one of her articles was awarded WILEY Top Cited Article 2020-2021. Dr Yin has been primary investigator of a grant (Health and Medical Research Fund) and co-investigator of two grants (HKU Seed Fund for Basic Research and RGC General Research Fund). She was awarded as one of Top 2% Scientists Worldwide 2023 by Stanford University.

Professor Ni ZHOU

Title

Effective Strategies for Managing Children with Autism Spectrum Disorder in the Dental Setting

Abstract

The prevalence of Autism Spectrum Disorder (ASD) has experienced a notable surge among children, necessitating the development of customised management strategies by dental professionals. This workshop will deliver informative lectures covering the general profile of ASD, including its causes, as well as the distinct medical and dental challenges associated with the condition. Additionally, the workshop will delve into effective strategies for behavioural dental management tailored made for autistic children. Through case showcases and interactive discussions, participants will have the opportunity to explore real-life scenarios and exchange valuable insights. Expert speakers will share practical techniques for managing the behavioural challenges commonly encountered during dental treatments for children with ASD. The workshop will conclude with a summary of key take-home messages and provide practical tips for dental professionals to effectively manage the dental care of autistic children and support their families. By the end of the workshop, participants will gain a comprehensive understanding of ASD and acquire enhanced skills in behavioural management techniques. This workshop aims to equip dental professionals with the necessary knowledge and skills to deliver optimal dental care for children with ASD, while effectively supporting their families.

Biography

Professor Ni Zhou is currently a Clinical Assistant Professor in Paediatric Dentistry at The University of Hong Kong. She received her basic dental training at Kunming Medical University. She then obtained Master’s degree in Paediatric Dentistry from the same University, and PhD from The University of Hong Kong. Her research interest is oral health promotion for children with special healthcare needs. Her paper entitled “Social story-based oral health promotion for preschool children with special healthcare needs: a 24-month randomized controlled trial” is the Top Cited Article 2020-2021 in Community Dentistry and Oral Epidemiology. She was also awarded the International Dental Collaboration of the Mekong River Region Scholarship in Thailand (2012), the First Prize in the National Oral Health Education Contest by the Chinese Stomatological Association (2013), Excellent Demonstration as Candidate of Finalist of the Unilever Hatton Divisional Award (Senior Category) in the 32nd International Association for Dental Research-Southeast Asian Division Annual Scientific Meeting in Vietnam (2018), the Provincial Health Science & Technology Award in Yunnan, China (2022), and the National Outstanding Young Lecturer by the Chinese Stomatological Association (2022).

Professor Hao YU

Title

Artificial Intelligence in Dentistry

Abstract

Artificial intelligence (AI) represents a wide array of evolving technologies that increasingly permeate everyday life. To explore the trajectory of AI within the dental sector, an extensive electronic search was conducted, supplemented by direct inquiries to companies offering AI-driven services in dentistry. Predominantly, AI applications in dentistry focus on diagnostic processes utilizing radiographic or optical images. Other dental tasks benefit less from AI integration, primarily due to limitations in data availability, uniformity, and the computational demands of processing 3D data. This review provides a comprehensive overview of current AI applications in clinical dentistry, aiming to enhance dental professionals' understanding of AI as a valuable tool. By incorporating AI, dental practitioners can achieve greater accuracy and efficiency in their routine tasks, ultimately elevating patient care standards. This presentation helps demystify AI technologies for dental professionals, encouraging more informed engagement with AI tools to optimize clinical outcomes.

Biography

Dr Hao Yu is a Clinical Professor (Prosthodontics) and an Associate Dean at the School and Hospital of Stomatology of Fujian Medical University, China. He earned doctorates from both Wuhan University (China) and University of Zurich (Switzerland). He also holds adjunct professorships at the dental schools of University of Zurich (Switerzland) and Nagasaki University (Japan). He is the vice president of Fujian Prosthodontics and Dental Materials Society, the vice president of Western Returned Scholars Association at Fujian Medical University, a standing committee member of Chinese Prosthodontics Society (CPS), and a standing committee member of Chinese Dental Materials Society. Dr Yu’s research interests include dental materials, tooth bleaching, prevention of dental erosion, and dental education. He published more than 100 peer reviewed journal articles and abstracts in international conferences, and served as Guest Editors of BioMed Research International and Frontiers in Materials. Dr Yu was awarded the Science & Technology Award for Young Talents of Fujian Province in 2021, the Fujian Medical Science and Technology Award in 2023, and was elected as a Fellow of International College of Dentists (FICD) in 2018.

Professor Dali ZHENG

Title

WNT7A, its secret of secretion and activation in HNSCC

Abstract

Wnt signaling is a critical pathway involved in organ development, tumorigenesis, and cancer progression. WNT7A, a member of the Wnt family, remains poorly understood in terms of its role and the underlying molecular mechanisms it entails in head and neck squamous cell carcinoma (HNSCC). According to the Cancer Genome Atlas (TCGA), transcriptome sequencing data of HNSCC, the expression level of WNT7A in tumors was found to be higher than in adjacent normal tissues, which was validated using Real-time RT-PCR and immunohistochemistry. Unexpectedly, overexpression of WNT7A did not activate the canonical Wnt-β-catenin pathway in HNSCC. Instead, our findings suggested that WNT7A potentially activated the FZD7/JAK1/STAT3 signaling pathway, leading to enhanced cell proliferation, self-renewal, and resistance to apoptosis. Furthermore, in a patient-derived xenograft (PDX) tumor model, high expression of WNT7A and phosphorylated STAT3 was observed, which positively correlated with tumor progression. Our results also indicated that the palmitoylation of WNT7A was important for its secretion and function. But which is the major palmitoyltransferases, and how the palmitoylation effect the secretion and stability of WNT7A still need further investigation.

Biography

Dr Dali ZHENG is a professor of Fujian Key laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University. He received BSc degree in Biochemistry from Fudan University, graduated with MSc in Immunology from Fujian Medical University, and obtained PhD in Biochemistry and Molecular Biology from Shanghai Jiaotong University. He was a postdoctoral research fellow at University of Missouri (USA) and Washington University in St Louis (USA) from 2009 to 2013, and research associate at Moffitt Cancer Center and University of South Florida (USA) from September of 2013 to January of 2018. He won the title of “Distinguished Professor of Minjiang Scholarship” in 2018 and is serving as academic editor for Biomedical Reports, Journal of Oncology, reviewer for several international journals such as Cancer Letters, Signal Transduction and Targeted Therapy, Cells, and so on. He published more than 80 research papers in international journals including Nature Nanotechnology, Oncogene, JCI, PNAS, and BMC Cancer and won First-class prize of Natural Science Award of Ministry of Education (4th authorship) in 2016 and Second-class prize of Scientific Innovation Award of Fujian Province (2nd authorship) in 2017. His research is mostly focused on the molecular biology of oral cancer and oral microenvironment.

Professor Jiang CHEN

Biography

Dr Jiang CHEN, Dean and Professor of School and Hospital of Stomatology Fujian Medical University. He obtained his M.D. and Ph.D. degrees in Oral and Maxillofacial Surgery from West China School of Stomatology, Sichuan University, China. He worked as a visiting scholar in Harvard School of Dental Medicine, Tufts-New England Medical Center, Massachusetts (USA) from 2000 to 2001. His research interests includes digital occluso-rehabilitation, maxillofacial tumor research, oral implant, clinical research of oral aesthetics. He has published nearly 100 papers and accomplished nearly 20 research projects, including 2 projects supported by the National Natural Science Foundation of China. He edited, translated and co-edited 11 academic monographs. Due to the outstanding achievements, he awarded as “National Excellent Scientist” and “Recipient of special subsidies acknowledged by the State Council”. He is also a fellow of International Team for Implantology (ITI), an expert reviewer of NSFC and CSC, editor in chief of JOMI Chinese edition, reviewer of clinical oral implant research, special reviewer of Chinese Journal of Stomatology, and deputy editor in chief of Journal of Stomatology. Being a well recognized expert in his field, Prof. Chen is appointed as Director of academic board, school and hospital of stomatology Fujian Medical University, Executive Director of Chinese Stomatological Association, Director of Oral Implantology Committee and Oral Aesthetics Committee of Chinese Stomatological. He was also elected as a Fellow of International College of Dentists (FICD).

Professor Hao YU

Biography

Dr Hao Yu is a Clinical Professor (Prosthodontics) and an Associate Dean at the School and Hospital of Stomatology of Fujian Medical University, China. He earned doctorates from both Wuhan University (China) and University of Zurich (Switzerland). He also holds adjunct professorships at the dental schools of University of Zurich (Switerzland) and Nagasaki University (Japan). He is the vice president of Fujian Prosthodontics and Dental Materials Society, the vice president of Western Returned Scholars Association at Fujian Medical University, a standing committee member of Chinese Prosthodontics Society (CPS), and a standing committee member of Chinese Dental Materials Society. Dr Yu’s research interests include dental materials, tooth bleaching, prevention of dental erosion, and dental education. He published more than 100 peer reviewed journal articles and abstracts in international conferences, and served as Guest Editors of BioMed Research International and Frontiers in Materials. Dr Yu was awarded the Science & Technology Award for Young Talents of Fujian Province in 2021, the Fujian Medical Science and Technology Award in 2023, and was elected as a Fellow of International College of Dentists (FICD) in 2018.

Professor Dali ZHENG

Biography

Dr Dali ZHENG is a professor of Fujian Key laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University. He received BSc degree in Biochemistry from Fudan University, graduated with MSc in Immunology from Fujian Medical University, and obtained PhD in Biochemistry and Molecular Biology from Shanghai Jiaotong University. He was a postdoctoral research fellow at University of Missouri (USA) and Washington University in St Louis (USA) from 2009 to 2013, and research associate at Moffitt Cancer Center and University of South Florida (USA) from September of 2013 to January of 2018. He won the title of “Distinguished Professor of Minjiang Scholarship” in 2018 and is serving as academic editor for Biomedical Reports, Journal of Oncology, reviewer for several international journals such as Cancer Letters, Signal Transduction and Targeted Therapy, Cells, and so on. He published more than 80 research papers in international journals including Nature Nanotechnology, Oncogene, JCI, PNAS, and BMC Cancer and won First-class prize of Natural Science Award of Ministry of Education (4th authorship) in 2016 and Second-class prize of Scientific Innovation Award of Fujian Province (2nd authorship) in 2017. His research is mostly focused on the molecular biology of oral cancer and oral microenvironment.

Dr Guo Wu GAN

Title

Gut Microbiota: Bridging Oral Health and Systemic Diseases

Abstract

The gut microbiota plays a crucial role in human health, influencing various physiological processes and immune responses. This lecture delves into the intricate relationship between oral health and the gut microbiota. Firstly, it elucidates the pivotal role of gut microbiota in maintaining overall health. Secondly, it discusses the correlation between periodontitis and alterations in gut microbiota composition, highlighting potential mechanisms linking the two, including the dysregulation of TH17/Treg balance. Additionally, it introduces the intriguing concept that oral saliva may harbor bacteria capable of surviving in the intestine, potentially impacting gut microbiota composition and systemic health. Furthermore, it examines the emerging evidence suggesting a link between apical periodontitis and disturbances in gut microbiota. Importantly, both apical periodontitis and periodontitis can compromise intestinal barrier function, leading to systemic repercussions. Moreover, apical periodontitis has been associated with disruptions in intestinal metabolism, particularly bile acid metabolism, which may have far-reaching implications for systemic health. These insights underscore the interconnectedness of oral and systemic health, emphasizing the potential of targeting gut microbiota to mitigate the risk of systemic diseases originating from oral conditions. Recognizing these complex interrelations provides a foundation for comprehensive approaches to promoting overall health and well-being.

Biography

Dr Gan is Senior Clinical Assistant Professor of School and Hospital of Stomatology, Fujian Medical University, he received his PhD degree from Fujian Medical University in 2022, specializing in endodontics, with a primary focus on the correlation between apical periodontitis and systemic diseases. He participated in one project of National Natural Science Foundation of China, led one project of Natural Science Foundation of Fujian Province, and one project of Fujian Provincial Health Department. And he has published two articles in the International Endodontic Journal and one article in the International Journal of Oral Science on apical periodontitis promoting atherosclerosis.

Dr De Xiong LI

Title

Functionalized mesoporous silica applied for infectious bone rehabilitation

Abstract

Existing implant materials cannot meet the essential multifunction of antibacterial and osteogenesis for repairing infected bone defects. A promising strategy maybe developing a versatile biomimicry composite by combining a multifunctional nanoparticle with an organic scaffold. In these studies, a drug delivery system with self-antifungal of a quaternary ammonium silane-modified mesoporous silica containing nano silver (Ag@QHMS) was synthesized. And further combined with silk fibroin (SF) to fabricate the multifunctional nano-reinforced scaffold (SF-Ag@QHMS) to mimic the natural bone nanostructure--a lamellar structure mixture of organic extracellular matrix components and inorganic calcium phosphate nanoparticles. Then, the antibacterial and osteogenic effects of this composite were evaluated then. The composite inherits the three-dimensional porous structure and better mechanical properties of the SF scaffold. Simultaneously, the introduction of versatile nanoparticles provided it with additional antibacterial ability against P. g. The expression of osteogenic-associated factors was up-regulated due to the eluted Ag. The animal model showed that the new bone formation was not only localized around the border of the defect but also arose more in the center with the support of the composite. In summary, the dual functions of antibacterial and osteogenesis of SF-Ag@QHMS composite has make it possible for infectious bone defects treatment.

Biography

Dr Dexiong Li is a Senior Clinical Assistant Professor (Implantology) of School and hospital of Fujian Medical University. He graduated from Fujian Medical University with a doctorate in June 2021. He is now a member of the Chinese Stomatological Association and the Special Committee for Oral Implantology and Aesthetic Professional Committee. He has presided over 2 research projects and has published 6 academic papers in journals. His main research field is the development and research of new oral biomaterials and versatile nano-biomaterials for soft and hard tissue regeneration around the implant.

Dr Yu PAN

Title

Optimizing Intraoral Scanning Accuracy: Insights into Interocclusal Relationships

Abstract

Intraoral scanners are pivotal in modern dentistry, providing a non-invasive, efficient method for capturing intraoral structures. Precise interocclusal relationships and optimal occlusal morphology reproduction are vital for successful final restorations and reducing potential complications. However, the accuracy of scans can vary depending on the scanning area, leading to different results. Quadrant scans for single-unit restorations have shown superior accuracy in reproducing occlusal morphologies. Nonetheless, not all intraoral scanners offer the same level of quality. Hence, it is crucial to identify any discrepancies during virtual mounting to prevent further occlusal mismatches. This study aimed to evaluate the accuracy of occlusal relationship registration using two intraoral scanners under different teeth preparation conditions (in terms of number, location and scan areas). Trueness and precision of buccal scans and occlusal relationships were quantitatively analyzed using high-precision scanning and reverse engineering software. Results showed that Primescan exhibited superior trueness in occlusal relationships for multiple anterior teeth preparations compared to Trios 4. Precision, however, did not significantly differ between the two scanners. The number of preparations influenced trueness but not precision. Both scanners recommended a longer scan area for anterior teeth, emphasizing the importance of selecting the appropriate scanning area for optimal results in intraoral scanning procedures.

Biography

Dr Yu PAN (BDS, PhD) is an Clinical Associate Professor at Department of prosthodontics, School and Hospital of Stomatology, Fujian Medical University. She received a PhD degree of Prosthodontics from Fujian Medical University in 2017. Dr.PAN serves as a youth committee of Chinese Specialty Committee on Prosthodontics and Dental materials,as well as a standing member of the Prosthodontics and Materials Technology Professional Committee of the Fujian Provincial Stomatological Association. She has led and participated in several national and provincial-level research projects, published six papers as the first author in SCI-indexed journals, including four in JCR-Q2 journals. She has received one second prize for Medical Science and Technology Progress in Fujian Province (as the sixth completed person), two patents in Fujian Province, and one third prize for outstanding natural science paper in Fujian Province. Her main research interests include artificial intelligence digitization, rapid UV light functionalization, and the biological properties of dental materials.

Professor Wen ZHOU

Title

pH-Responsive nanocomplex for Caries Prevention and Treatment

Abstract

Caries threaten the oral and systemic health of human. Prevention of caries in early stage is a critical issue for public health. However, the utilization rate of traditional anti-caries drugs is low. And they are prone to disturbing the balance of oral microecology and inducing drug resistance. Therefore, the present study developed a pH-responsive antimicrobial and remineralization promoting nanocomposite to solve the problems above. Antibacterial quaternary ammonium compounds dimethylaminohexadecyl methacrylate (DMAHDM) were loaded with pH-responsive dendrimer polyamides (PAMAM-Acetal). Thus DMAHDM-PAMAM-Acetal nanocomplex will present both pH-responsive antibacterial and remineralization promotion effectiveness. Basic characteristics of the nanocomplex were measured. The caries preventive effectiveness was tested in vitro. The results indicated that the pH-responsive nanocomplex can identify decreased pH levels in microenvironment, realizing on-demand antibacterial agent releasing. And the nanocomplex provided remineralization promoting effectiveness at the same time.

Biography

Dr Wen Zhou is associate clinical professor and postgraduate student tutor at School and Hospital of Stomatology, Fujian Medical University. She is also a Fijian High-level talent. She obtained her BDS to MDD degree from the West China School of Stomatology, Sichuan University. She worked as visiting scholar in University of Maryland (USA) for one and a half year, sponsored by CSC scholarship. Her research focuses on the dental biomaterials and oral microbiology. Dr. Zhou has published 14 articles on journals such as Acta Biomaterialia, Dental Materials and Journal of Dentistry. Additionally, She serves as peer reviewer for Dental Materials and other dental journals. She has accomplished 5 research projects, including projects supported by the Natural Science Foundation of Fujian Province, Postdoctoral Research Foundation of China.