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Dr Li, Xuan  portrait
Faculty Staff
Dr Li, Xuan
BEng, MMed (SWJTU); PhD (HK)
General Information
Post-doctoral Fellow in Nanomedicine for Oral/Periodontal Care
Periodontology & Implant Dentistry
Research profile
Research Theme
Craniofacial Regeneration
Advanced Sorting
  1. Lan XM, Zhong J, Huang R, Liu YH, Ma XW, Li X, Zhao D, Qing GC, Zhang YX, Liu L, Wang JJ, Ma X, Luo T, Guo WS, Wang YJ, Li LL, Su YX, Liang XJ. Conformation Dependent Architectures of Assembled Antimicrobial Peptides with Enhanced Antimicrobial Ability, Advanced Healthcare Materials 2023; doi:10.1002/adhm.202301688
  2. Wang Leilei, Wang Chuan, Li Xuan, Tao Zhuoying, Zhu Wangyong, Su Yuxiong, Choi Wing Shan. Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS, Cellular & Molecular Biology Letters 2023; 28(1) doi:10.1186/s11658-023-00449-6
  3. Sun H, Chan YK, Li X, Xu R, Zhang Z, Hu X, Wu F, Deng F, Yu X. Multi-omics analysis of oral bacterial biofilm on titanium oxide nanostructure modified implant surface: In vivo sequencing-based pilot study in beagle dogs, Materials Today Bio 2022; 15: 100275-100275 doi:10.1016/j.mtbio.2022.100275
  4. WANG C, Li X, Cheng T, WANG L, Jin L. RNA Sequencing Reveals the Upregulation of FOXO Signaling Pathway in Porphyromonas gingivalis Persister-Treated Human Gingival Epithelial Cells, International Journal of Molecular Sciences 2022; 23: 5728-5728 doi:10.3390/ijms23105728
  5. Li X, Wang C, WANG L, HUANG R, Li W, Wang X, Wong SSW, Cai Z, Leung KCF, Jin L. A glutathione-responsive silica-based nanosystem capped with in-situ polymerized cell-penetrating poly(disulfide)s for precisely modulating immuno-inflammatory responses, Journal of Colloid and Interface Science 2022; 614: 322-336 doi:10.1016/j.jcis.2022.01.091
  6. WANG C, Li X, Cheng T, Sun H, Jin L. Eradication of Porphyromonas gingivalis Persisters Through Colloidal Bismuth Subcitrate Synergistically Combined With Metronidazole, Frontiers in Microbiology 2021; 12: article no. 748121-article no. 748121 doi:10.3389/fmicb.2021.748121
  7. Chung ACK, Li X, Li WC, Wang T, Lee HK, Jin L, Cai Z, Leung KCF. Mass spectrometry imaging and monitoring of in vivo glutathione-triggered cisplatin release from nanoparticles in the kidneys, Nanoscale Advances 2020; 2(12): 5857-5865 doi:10.1039/D0NA00708K
  8. WANG C, Cheng T, Li X, Jin L. Metronidazole-Treated Porphyromonas gingivalis Persisters Invade Human Gingival Epithelial Cells and Perturb Innate Responses, Antimicrobial Agents and Chemotherapy 2020; 64(6): article no. e02529-19 doi:10.1128/AAC.02529-19
  9. Li X, Huang R, Tang FK, Li WC, Wong SSW, Leung KCF, Jin L. Red-Emissive Guanylated Polyene-Functionalized Carbon Dots Arm Oral Epithelia against Invasive Fungal Infections, ACS Applied Materials & Interfaces 2019; 11: 46591-46603 doi:10.1021/acsami.9b18003
  10. Leung KCF, Li XB, Li X, Lee SF, Yu JC, Mendes PM, Hermann KE, Van Hove MA. Soft Nanohand Grabs a Growing Nanoparticle, Materials Chemistry Frontiers 2019; 3(8): 1555-1564 doi:10.1039/C9QM00132H
  11. Lan X, She J, Lin D, Xu Y, Li X, Yang W, Lui VWY, Jin L, Xie X, Su Y. Microneedle-Mediated Delivery of Lipid-Coated Cisplatin Nanoparticles for Efficient and Safe Cancer Therapy, ACS Applied Materials & Interfaces 2018; 10(39): 33060-33069 doi:10.1021/acsami.8b12926
  12. Li X, Li X, Wang S, Leung CFK, Zhang C, Jin L. Infiltration and Profiles of Mesoporous Silica Nanoparticles in Dentinal Tubules, ACS Biomaterials Science & Engineering 2018; 4: 1428-1436 doi:10.1021/acsbiomaterials.7b00919
  13. LI X, Luo W, Ng TC, Leung PC, Zhang C, Leung CFK, Jin L. Nanoparticle-encapsulated baicalein markedly modulates pro-inflammatory response in gingival epithelial cells, Nanoscale 2017; 9: 12897-12907 doi:10.1039/C7NR02546G
  14. Leung KCF, Seneviratne CJ, Li X, Leung PC, Lau CBS, Wong CH, Pang KY, Wong CW, Wat E, Jin L. Synergistic Antibacterial Effects of Nanoparticles Encapsulated with Scutellaria baicalensis and Pure Chlorhexidine on Oral Bacterial Biofilms, Nanomaterials 2016; 6: 61-61 doi:10.3390/nano6040061
  15. LI X, Wong CH, Ng TW, Zhang C, Leung KCF, Jin L. The spherical nanoparticle-encapsulated chlorhexidine enhances anti-biofilm efficiency through an effective releasing mode and close microbial interactions, International Journal of Nanomedicine 2016; 11: 2471-2471 doi:10.2147/IJN.S105681
  16. LI X, Pang KY, Ng TW, Leung PC, Zhang C, Leung KCF, Jin L. Cellular Interactions and Formation of an Epithelial “Nanocoating-Like Barrier” with Mesoporous Silica Nanoparticles, Nanomaterials 2016; 6: 192-192 doi:10.3390/nano6110192
  17. Wang Sheng, Guo Lan Ping, Xie Teng, Yang Jian, Tang Jin Fu, Li Xuan, Wang Xiao, Huang Lu Qi. Different secondary metabolic responses to MeJA treatment in shikonin-proficient and shikonin-deficient cell lines from Arnebia euchroma (Royle) Johnst, Plant Cell, Tissue and Organ Culture 2014; 119(3): 587-598 doi:10.1007/s11240-014-0558-5
  18. Seneviratne CJ, Leung CFK, Wong CH, Lee SF, LI X, Leung PC, Lau CBS, Wat E, Jin L. Nanoparticle-encapsulated chlorhexidine against oral bacterial biofilms, PLoS ONE 2014; 9: e103234-e103234 doi:10.1371/journal.pone.0103234
  19. Li Xuan, Wang Sheng, Guo Lanping, Huang Luqi. Effect of cadmium in the soil on growth, secondary metabolites and metal uptake in Salvia miltiorrhiza, Toxicological and Environmental Chemistry 2013; 95(9): 1525-1538 doi:10.1080/02772248.2014.887717
  20. Li Xuan, Yue Hong, Wang Sheng, Huang Lu Qi, Ma Jiong, Guo Lan Ping. Research of different effects on activity of plant antioxidant enzymes, Zhongguo Zhongyao Zazhi 2013; 38(7): 973-978 doi:10.4268/cjcmm20130709
  21. Guo Lan Ping, Wang Sheng, Zhang Ji, Yang Guang, Zhao Man Xi, Ma Wei Feng, Zhang Xiao Bo, Li Xuan, Han Bang Xing, Chen Nai Fu, Huang Lu Qi. Effects of ecological factors on secondary metabolites and inorganic elements of Scutellaria baicalensis and analysis of geoherblism, Science China Life Sciences 2013; 56(11): 1047-1056 doi:10.1007/s11427-013-4562-5
  22. Zhou Jie, Fang Lei, Li Xuan, Guo Lanping, Huang Luqi. Jasmonic acid (JA) acts as a signal molecule in LaCl3-induced baicalin synthesis in Scutellaria baicalensis seedlings, Biological Trace Element Research 2012; 148(3): 392-395 doi:10.1007/s12011-012-9379-8
  23. Wang Sheng, Li Xuan, Jiang Chao, Guo Lan Ping. Advances in studies on genes related to shikonin and its derivatives biosynthesis and signal transduction, Chinese Traditional and Herbal Drugs 2012; 43(6): 1219-1225
  24. Li Xuan, Zhao Manxi, Guo Lanping, Huang Luqi. Effect of cadmium on photosynthetic pigments, lipid peroxidation, antioxidants, and artemisinin in hydroponically grown Artemisia annua, Journal of Environmental Sciences (China) 2012; 24(8): 1511-1518 doi:10.1016/S1001-0742(11)60920-0
Conference Paper
  1. Huang R, Li X, Leung CFK, Jin L. Ultrasound-assisted synthesis of bismuth-metal organic frameworks for suppressing Porphyromonas gingivalis, Journal of Dental Research (Spec Issue) 2021; 100(Spec Iss A): presentation ID 2109-presentation ID 2109
  2. Li X, HUANG R, Fang FK, Li WC, Wong SSW, Leung CFK, Jin L. Oral epithelia enhanced by red-emitting amphotericin b-conjugated carbon dots perturb the adherence and invasion of Candida albicans, The 11th World Biomaterials Congress (WBC 2020) 2020;
  3. HUANG R, Li X, Leung CFK, Jin L. Antibiotic-free, bismuth-doped carbon dots for suppression on P. gingivalis, The 11th World Biomaterials Congress (WBC 2020) 2020;
  4. Wang C, Li X, Cheng T, Jin L. Metronidazole-tolerant Porphyromonas gingivalis persisters dampen cytokine expression in HGECs, Journal of Dental Research (Spec Issue) 2019; 98(Spec Iss A): abstract no. 2313-abstract no. 2313
PG Thesis
  1. Li Xuan Mesoporous silica nanoparticle-encapsulated antimicrobials and Chinese herbal extracts : controlling oral microbes, modulating immuno-inflammatory response & perspectives[PG Thesis]. Pokfulam, Hong Kong: The University of Hong Kong; 2017.
Professional Societies
  1. 06/2020-06/2023: MRSC. Royal Society of Chemistry.
  1. Project Title: Novel injectable hydrogels encapsulated with bismuth-doped carbon dots-based nanomedicine for periodontal treatment and healthcare via antimicrobial & immuno-modulatory approaches
    Grant Type: External Grant
    Funding Year: 2020
    Amount: HKD1090248
    Principal Investigator: Dr Li, Xuan
    Co-investigator(s): Dr Cheng Tianfan, Dr Yu Xiaolin, Dr Wong Sze Wah Sarah, Dr Leung Ken Cham-fai, Dr Lan Xinmiao, Professor Jin Lijian
  2. Project Title: A pioneering study on nano-reinforced multifunctional ‘barrier’ of human gingival epithelia loaded with nanoparticles-based antimicrobials and immunoinflammatory modulators
    Grant Type: External Grant
    Funding Year: 2018
    Amount: HKD1356480
    Principal Investigator: Professor Jin, Lijian
    Co-investigator(s): Dr Leung Ken Cham-fai, Dr Li Xuan
Invited Lectures and Keynote Speeches
  1. 31 July 2020: Nano-based drug delivery system for oral/periodontal healthcare: An update and perspective. 1st ‘Young Researchers Forum of IADR - Asia Pacific Region’.
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