Profile
- Research Assistant Professor
助理教授（研究）
Periodontology & Implant Dentistry
+852 2859 0571
- Clinical multi-omic analysis
- Molecular mechanisms of pathogenesis of periodontitis and relating systemic conditions
- Chemical biology of bacteria and host-microbe interactions
- Innovative antimicrobial drug development
Article
- Hou Shuwen, Jiang Yuesong, Zhang Feng, Cheng Tianfan, Zhao Dan, Yao Jilong, Wen Ping, Jin Lijian, Huang Shi. Unveiling early-life microbial colonization profile through characterizing low-biomass maternal-infant microbiomes by 2bRAD-M, Frontiers in Microbiology 2025; 16
- Song Danni, Chen Beibei, Cheng Tianfan, Jin Lijian, He Jiangfeng, Li Yongming, Liao Chongshan. Attenuated NIX in impaired mitophagy contributes to exacerbating cellular senescence in experimental periodontitis under hyperglycemic conditions, FEBS Journal 2025; 292(7): 1726-1742
- Zhao Zelda Ziyi, Guo Lifeng, Li Xiangyang, Cheng Tianfan, Chu Chun Hung, Zhang Jing. Quorum quenching by Est816: a novel approach to control Porphyromonas gingivalis pathogenicity, BMC Oral Health 2025; 25(1): article no. 1178-article no. 1178
- Chen Beibei, Song Danni, Cheng Tianfan, Jin Lijian, Li Yongming, Liao Chongshan. Neutrophil extracellular traps aggravate periodontitis by disturbing regulatory T-cell differentiation, Genes and Immunity 2025; 26(5): 475-485
- Zhao Zelda Ziyi, Shan Wenwen, Sun Xiaoyu, Cheng Tianfan, Zhang Jing, Chu Chun Hung. Quorum-Quenching AHL-Lactonase Est816 Inhibits Polymicrobial Subgingival-Plaque-Derived Biofilm Formation, Dentistry Journal 2025; 13(8): article no. 372-article no. 372
- Zhou Ying, Cheng Tianfan, Tang Kaiming, Li Hongyan, Luo Cuiting, Yu Fu, Xiao Fan, Jin Lijian, Hung Ivan Fan Ngai, Lu Liwei, Yuen Kwok Yung, Chan Jasper Fuk Woo, Yuan Shuofeng, Sun Hongzhe. Integration of metalloproteome and immunoproteome reveals a tight link of iron-related proteins with COVID-19 pathogenesis and immunity, Clinical Immunology 2024; 263
- Song Danni, He Jiangfeng, Cheng Tianfan, Jin Lijian, Li Sijin, Chen Beibei, Li Yongming, Liao Chongshan. Cystathionine γ-lyase contributes to exacerbation of periodontal destruction in experimental periodontitis under hyperglycemia, Journal of Periodontology 2024;
- Wen Ping, Li Huijun, Xu Xiaoyi, Zhang Feng, Zhao Dan, Yu Rong, Cheng Tianfan, Wang Hao, Yang Chuanzhong, Qin Wei, Yang Xiuqiao, Yao Jilong, Jin Lijian. A prospective study on maternal periodontal diseases and neonatal adverse outcomes, Acta Odontologica Scandinavica 2024; 83: 348-355
- Zhao Zelda Ziyi, Wang Junmin, Liu Xinpai, Wang Zezhi, Zheng Xianyu, Li Wuli, Cheng Tianfan, Zhang Jing. N-acyl homoserine lactones lactonase est816 suppresses biofilm formation and periodontitis in rats mediated by Aggregatibacter actinomycetemcomitans, Journal of Oral Microbiology 2024; 16(1)
- Cheng Tianfan, Wen Ping, Yu Rong, Zhang Feng, Li Huijun, Xu Xiaoyi, Zhao Dan, Liu Fang, Su Weilan, Zheng Zheng, Yang Hong, Yao Jilong, Jin Lijian. Integrative microbiome and metabolome profiles reveal the impacts of periodontitis via oral-gut axis in first-trimester pregnant women, Journal of Translational Medicine 2024; 22(1)
- Zhang Feng, Zhao Dan, Xu Xiaoyi, Wen Ping, Li Huijun, Yu Rong, Cheng Tianfan, Zheng Zheng, Yang Hong, Yang Chuanzhong, Yao Jilong, Jin Lijian. Periodontitis links to concurrent metabolic disorders and abnormal liver function in pregnant women, Oral Diseases 2024; 30(2): 697-709
- Zhao D, Cheng TF, Hu DL, Xu XY, Zhang F, Yu R, Li HJ, Wen P, Chen LH, Fu ML, Yang H, Zhang HY, Yao JL, Jin LJ. Maternal periodontal diseases affect the leukocyte profiles of umbilical cord blood: A cohort study, Oral Diseases 2023;
- Xia Yuxing, Cheng Tianfan, Zhang Chengfei, Zhou Min, Hu Zhekai, Kang Feiwu, Liao Chongshan. Human bone marrow mesenchymal stem cell‐derived extracellular vesicles restore Th17/Treg homeostasis in periodontitis via miR‐1246, The FASEB Journal 2023; 37(11)
- Zhou Ying, Yuan Shuofeng, Xiao Fan, Li Hongyan, Ye Ziwei, Cheng Tianfan, Luo Cuiting, Tang Kaiming, Cai Jianpiao, Situ Jianwen, Sridhar Siddharth, Chu Wing-Ming, Tam Anthony Raymond, Chu Hin, Che Chi-Ming, Jin Lijian, Hung Ivan Fan-Ngai, Lu Liwei, Chan Jasper Fuk-Woo, Sun Hongzhe. Metal-coding assisted serological multi-omics profiling deciphers the role of selenium in COVID-19 immunity, Chemical Science 2023; 14(38): 10570-10579
- Hu Dangli, Wang Jianmei, Cheng Tianfan, Li Huijun, Zhang Feng, Zhao Dan, Xu Xiaoyi, Yu Rong, Wen Ping, Cheng Yunfei, Xu Jian, Jin Lijian, Yao Jilong. Comparative analysis of serum and saliva samples using Raman spectroscopy: a high-throughput investigation in patients with polycystic ovary syndrome and periodontitis, BMC Women's Health 2023; 23(1)
- Huang Regina, Zhou Zhiwen, Lan Xinmiao, Tang Fung Kit, Cheng Tianfan, Sun Hongzhe, Cham-Fai Leung Ken, Li Xuan, Jin Lijian. Rapid synthesis of bismuth-organic frameworks as selective antimicrobial materials against microbial biofilms, Materials Today Bio 2023; 18: article no. 100507-article no. 100507
- Liu Jieying, Li Tianle, Zhang Shunhao, Lu Eryi, Qiao Wei, Chen Huimin, Liu Peng, Tang Xiaoyue, Cheng Tianfan, Chen Hui. Proteomic and single-cell analysis shed new light on the anti-inflammatory role of interferonβ in chronic periodontitis, Frontiers in Pharmacology 2023; 14: article no. 1232539-article no. 1232539
- Mohamadi Ahmad, Cheng Tianfan, Jin Lijian, Wang Junwen, Sun Hongzhe, Koohi-Moghadam Mohamad. An ensemble 3D deep-learning model to predict protein metal-binding site, Cell Reports Physical Science 2022; 3(9): article no. 101046-article no. 101046
- Wang Chuan, Li Xuan, Cheng Tianfan, Wang Leilei, Jin Lijian. RNA Sequencing Reveals the Upregulation of FOXO Signaling Pathway in Porphyromonas gingivalis Persister-Treated Human Gingival Epithelial Cells, International Journal of Molecular Sciences 2022; 23(10): article no. 5728-article no. 5728
- Deng Hui, Gong Yixuan, Chen Yuan, Zhang Guigui, Chen Hui, Cheng Tianfan, Jin Lijian, Wang Yi. Porphyromonas gingivalis lipopolysaccharide affects the angiogenic function of endothelial progenitor cells via Akt/FoxO1 signaling, Journal of Periodontal Research 2022; 57(4): 859-868
- Li Hui Jun, Zhao Dan, Xu Xiaoyi, Yu Rong, Zhang Feng, Cheng Tianfan, Zheng Zheng, Yang Hong, Yang Chuanzhong, Yao Jilong, Wen Ping, Jin Lijian. Diagnostic performance of the AAP/EFP classification and the CDC/AAP case definition among pregnant women and a practical screening tool for maternal periodontal diseases, Journal of Periodontal Research 2022; 57(5): 960-968
- Zhao Dan, Cheng Tianfan, Koohi-Moghadam Mohamad, Wu Mei Zhen, Yu Shuk Yin, Ding Xun, Pelekos George, Yiu Kai Hang, Jin Lijian. Salivary ACE2 and TMPRSS2 link to periodontal status and metabolic parameters, Clinical and Translational Discovery 2022; 2(1): article no. e37-article no. e37
- Lin Y, Cheng T, Zhu S, Gu M, Jin L, Yang Y. mRNA and long non-coding RNA expression profiling of human periodontal ligament cells under tension loading, European Journal of Orthodontics 2021; 43(6): 698-707
- WANG C, Li X, Cheng T, Sun H, Jin L. Eradication of Porphyromonas gingivalis Persisters Through Colloidal Bismuth Subcitrate Synergistically Combined With Metronidazole, Frontiers in Microbiology 2021; 12: article no. 748121-article no. 748121
- WANG C, Cheng T, Li X, Jin L. Metronidazole-Treated Porphyromonas gingivalis Persisters Invade Human Gingival Epithelial Cells and Perturb Innate Responses, Antimicrobial Agents and Chemotherapy 2020; 64(6): article no. e02529-19
- Yuan S, Wang R, Chan JFW, Zhang AJ, Cheng T, Chik KKH, Ye ZW, Wang S, Lee ACY, Jin L, Li H, Jin DY, Yuen KY, Sun H. Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters, Nature Microbiology 2020; 5(11): 1439-1448
- Cheng T, Lai YT, WANG C, WANG Y, Jiang N, Li H, Sun H, Jin L. Bismuth drugs tackle Porphyromonas gingivalis and attune cytokine response in human cells, Metallomics 2019; 11(7): 1207-1218
- Curtin JP, Wang M, Cheng T, Jin L, Sun H. The role of citrate, lactate and transferrin in determining titanium release from surgical devices into human serum, Journal of Biological Inorganic Chemistry 2018; 23: 471-480
- Jiang N, Cheng T, Wang M, Chan GCF, Jin L, Li H, Sun H. Tracking iron-associated proteomes in pathogens by a fluorescence approach, Metallomics 2018; 10(1): 77-82
- LIAO C, Cheng T, WANG S, Zhang C, Jin L, Yang Y. Shear stress inhibits IL-17A-mediated induction of osteoclastogenesis via osteocyte pathways, Bone 2017; 101: 10-20
- Chang YY, Cheng T, Yang X, Jin L, Sun H, Li H. Functional disruption of peroxiredoxin by bismuth antiulcer drugs attenuates Helicobacter pylori survival, Journal of Biological Inorganic Chemistry 2017; 22: 673-683
- Lai YT, Yang Y, Hu L, Cheng T, Chang YY, Koohi-Moghadam M, Wang Y, Xia J, Wang J, Li H, Sun H. Integration of fluorescence imaging with proteomics enables visualization and identification of metallo-proteomes in living cells, Metallomics 2017; 9(1): 38-47
- Cheng T, Li H, Xia W, Jin L, Sun H. Exploration into the nickel ‘microcosmos’ in prokaryotes, Coordination Chemistry Reviews 2016; 311: 24-37
- Chang YY, Lai YT, Cheng T, Wang H, Yang Y, Sun H. Selective interaction of Hpn-like protein with nickel, zinc and bismuth in vitro and in cells by FRET, Journal of Inorganic Biochemistry 2015; 142: 8-14
- YANG X, Li H, Cheng T, Xia W, Lai AYT, Sun H. Nickel Translocation between Metallochaperones HypA and UreE in Helicobacter pylori, Metallomics 2014;
- Cheng Tianfan, Sun Hongzhe. Antimony and bismuth, Rsc Metallobiology 2014; 2014-January(2): 768-799
- Hu L, Cheng T, He B, Li L, Wang Y, Lai YT, Jiang G, Sun H. Identification of metal-associated proteins in cells by using continuous-flow gel electrophoresis and inductively coupled plasma mass spectrometry, Angewandte Chemie International Edition 2013; 52(18): 4916-4920
- Cheng T, Li H, Yang X, Xia W, Sun H. Interaction of SlyD with HypB of Helicobacter pylori facilitates nickel trafficking, Metallomics 2013;
- CHENG T, XIA W, WANG P, HUANG F, Wang JJ, Sun H. Histidine-rich proteins in prokaryotes: metal homeostasis and environmental habitat-related occurrence, Metallomics 2013; 5(10): 1423-1429
- YANG X, Xu D, Cheng T, Xi Z, Zhao L, Liu Y, Sun H. Recent progress of copper and nickel chaperones, Progress in Chemistry 2013; 25(4): 495-510
- Cheng T, Li H, Xia W, Sun H. Multifaceted SlyD from Helicobacter pylori: implication in [NiFe] hydrogenase maturation, Journal of Biological Inorganic Chemistry 2012; 17(3): 331-343
- Cheng Tianfan, Chen Maolin, Zheng Huabao, Wang Jingang, Yang Sheng, Jiang Weihong. Expression and purification of penicillin G acylase enzymes from four different micro-organisms, and a comparative evaluation of their synthesis/hydrolysis ratios for cephalexin, Protein Expression and Purification 2006; 46(1): 107-113
- Zhang Gui Shan, Jia Xiao Ming, Cheng Tian Fan, Ma Xiao Hang, Zhao Yu Hua. Isolation and characterization of a new carbendazim-degrading Ralstonia sp. strain, World Journal of Microbiology and Biotechnology 2005; 21(3): 265-269
- Cheng Tian Fan, Jia Xiao Ming, Ma Xiao Hang, Lin Hai Ping, Zhao Yu Hua. Phylogenetic study on Shiraia bambusicola by rDNA sequence analyses, Journal of Basic Microbiology 2004; 44(5): 339-350
- Hu Xuefeng, Cheng Tianfan, Wu Hexin. Do multiple cycles of aeolian deposit-pedogenesis exist in the reticulate red clay sections in southern China?, Chinese Science Bulletin 2003; 48(12): 1251-1258
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- 2023. CHAN Chun Lung, Sun H, Yuen KY, Yuan S, Wang R, Li H, Chan JFW, Cheng T, Wang S. Gold medal for 48th international exhibition of inventions of Geneva: The 48th Geneva International Inventions Exhibition (26/04/2023-30/10/2023, Geneva).
- 2015. Cheng T. Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2015-16: University Research Committee (URC).
- 2011. Sun H, Li H, Xia W, Cheng T. The Protein Society Finn Wold Travel Award: The 25th Anniversary Symposium of The Protein Society.
- Project Title: Novel injectable hydrogels encapsulated with bismuth-doped carbon dots-based nanomedicine for periodontal treatment and healthcare via antimicrobial & immuno-modulatory approaches
Grant Type: Health and Medical Research Fund - Full Grant
Funding Year: 2020
Amount: HK$1,090,248
Principal Investigator: Professor Li, Xuan
Co-investigator(s): Professor Jin Lijian, Dr Leung Ken Cham-fai, Dr Cheng Tianfan, Dr Yu Xiaolin, Dr Wong Sze Wah Sarah, Dr Lan Xinmiao
- Project Title: Development of Novel Inhibitors for Combatting SARS-CoV-2 Infection
Grant Type: Innovation and Technology Support Programme (Seed Project)
Funding Year: 2020
Amount: HK$1,195,402
Principal Investigator: Professor Sun, Hongzhe
Co-investigator(s): Dr Cheng Tianfan, Dr Wang Runming, Dr Li Hongyan, Professor Chan Jasper Fuk Woo, Professor Yuan Shuofeng
- Project Title: Novel approaches to combating the keystone periodontopathogen Porphyromonas gingivalis in infected host cells via multi-omic integrative analyses
Grant Type: General Research Fund (GRF)
Funding Year: 2019
Amount: HK$1,116,019
Principal Investigator: Professor Jin, Lijian
Co-investigator(s): Dr Cheng Tianfan, Professor Sun Hongzhe
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