Intranet Alumni HKU Portal HKU Contact Us

鄧妤

Professor Deng, Yu

PhD (HKU)

Professor Deng, Yu 鄧妤 - HKU Faculty of Dentistry 香港大學牙醫學院

Profile

Title
  • Assistant Professor in Molecular Microbiology
    分子微生物學助理教授
Division
Applied Oral Sciences & Community Dental Care
E-mail
dengyu@hku.hk
Phone
+852 2859 0575
Research Theme
Microbiome Innovation
Areas of Research Expertise
  • Oral Microbiome and Environmental Interactions
  • Antibiotic Resistance and Oral Pathogens
  • Phage Biology and Genomics in Oral Health
Research Profile
Publication & Awards
Publications

    Article

  • Mao Xuemei, Yin Xiaole, Yang Yu, Gao Fangzhou, Li Shuxian, Shi Xianghui, Deng Yu, Li Liguan, Leung Kenneth M.Y., Zhang Tong. Longitudinal metagenomic analysis on antibiotic resistome, mobilome, and microbiome of river ecosystems in a sub-tropical metropolitan city, Water Research 2025; 274 doi:10.1016/j.watres.2025.123102
  • Wang Chunxiao, Yang Yu, Xu Xiaoqing, Wang Dou, Shi Xianghui, Liu Lei, Deng Yu, Li Liguan, Zhang Tong. The quest for environmental analytical microbiology: absolute quantitative microbiome using cellular internal standards, Microbiome 2025; 13(1): 26
  • Xu Xiaoqing, Lin Yunqi, Deng Yu, Liu Lei, Wang Dou, Tang Qinling, Wang Chunxiao, Chen Xi, Che You, Wyrsch Ethan R., Jarocki Veronica M., Djordjevic Steven P., Zhang Tong. Ecological connectivity of genomic markers of antimicrobial resistance in Escherichia coli in Hong Kong, Nature Communications 2025; 16(1) doi:10.1038/s41467-025-62455-w
  • Zheng Xiawan, Leung Kathy, Xu Xiaoqing, Deng Yu, Zhang Yulin, Chen Xi, In Yau Chung, WK Hui Kenny, Pak Eddie, Chui Ho-Kwong, Yang Ron, Tun Hein Min, Leung Gabriel M, Wu Joseph T, Peiris Malik, Poon Leo LM, Zhang Tong. Wastewater Surveillance Provides Spatiotemporal SARS-CoV-2 Infection Dynamics, Engineering 2024; doi:10.1016/j.eng.2024.01.016
  • Huang Yue, Pan Anxin, Song Ying, Deng Yu, Wu Alnwick Long Hei, Lau Colin Shiu Hay, Zhang Tong. Strain-level diversity in sulfonamide biodegradation: adaptation of Paenarthrobacter to sulfonamides , The ISME Journal: Multidisciplinary Journal of Microbial Ecology 2024; 18(1) doi:10.1093/ismejo/wrad040
  • Xu Xiaoqing, Deng Yu, Ding Jiahui, Tang Qinling, Lin Yunqi, Zheng Xiawan, Zhang Tong. High-resolution and real-time wastewater viral surveillance by Nanopore sequencing, Water Research 2024; 256 doi:10.1016/j.watres.2024.121623
  • Tang Aixi, Zhang Jiayu, Huang Jin, Deng Yu, Wang Dou, Yu Pingfeng, Zhao Renxin, Wang Yulin, Chen Zihan, Zhang Tong, Li Bing. Decrypting the viral community in aerobic activated sludge reactors treating antibiotic production wastewater, Water Research 2024; 265 doi:10.1016/j.watres.2024.122253
  • Mei Zhi, Wang Fang, Fu Yuhao, Liu Yu, Hashsham Syed A, Wang Yu, Harindintwali Jean Damascene, Dou Qingyuan, Virta Marko, Jiang Xin, Deng Yu, Zhang Tong, Tiedje James M. Biofilm enhanced the mitigations of antibiotics and resistome in sulfadiazine and trimethoprim co-contaminated soils, Journal of Hazardous Materials 2024; 479 doi:10.1016/j.jhazmat.2024.135721
  • Wang Dou, Liu Lei, Xu Xiaoqing, Wang Chunxiao, Wang Yulin, Deng Yu, Zhang Tong. Distributions, interactions, and dynamics of prokaryotes and phages in a hybrid biological wastewater treatment system, Microbiome 2024; 12(1) doi:10.1186/s40168-024-01853-6
  • Mao Xuemei, Yin Xiaole, Yang Yu, Che You, Xu Xiaoqing, Deng Yu, Li Liguan, Zhang Tong. Standardization in global environmental antibiotic resistance genes (ARGs) surveillance, Critical Reviews in Environmental Science and Technology 2024; 54(22): 1633-1650 doi:10.1080/10643389.2024.2344453
  • Zheng X, Wang M, Deng Y, Xu X, Lin D, Zhang Y, Li S, Ding J, Shi X, Yau CY, Poon LML, Zhang T. A rapid, high-throughput, and sensitive PEG-precipitation method for SARS-CoV-2 wastewater surveillance, Water Research 2023; 230: 119560-119560 doi:10.1016/j.watres.2022.119560
  • Xu Xiaoqing, Deng Yu, Ding Jiahui, Shi Xianghui, Zheng Xiawan, Wang Dou, Yang Yu, Liu Lei, Wang Chunxiao, Li Shuxian, Gu Haogao, Poon Leo L.M., Zhang Tong. Refining detection methods for emerging SARS-CoV-2 mutants in wastewater: A case study on the Omicron variants, Science of the Total Environment 2023; 904: article no. 166215-article no. 166215 doi:10.1016/j.scitotenv.2023.166215
  • Xu Xiaoqing, Deng Yu, Ding Jiahui, Zheng Xiawan, Wang Chunxiao, Wang Dou, Liu Lei, Gu Haogao, Peiris Malik, Poon Leo L.M., Zhang Tong. Wastewater genomic sequencing for SARS-CoV-2 variants surveillance in wastewater-based epidemiology applications, Water Research 2023; 244: article no. 120444-article no. 120444 doi:10.1016/j.watres.2023.120444
  • Zheng Xiawan, Zhao Keyue, Xu Xiaoqing, Deng Yu, Leung Kathy, Wu Joseph T, Leung Gabriel M, Peiris Malik, Poon Leo LM, Zhang Tong. Development and application of influenza virus wastewater surveillance in Hong Kong, Water Research 2023; 245 doi:10.1016/j.watres.2023.120594
  • Huang Yue, Law Japhet Cheuk Fung, Wang Yulin, Deng Yu, Liu Lei, Zhang Yulin, Ding Jiahui, Yang Yu, Leung Kelvin Sze Yin, Zhang Tong. Sucralose biodegradation and enriched degrading consortia revealed by combining Illumina and Nanopore sequencing, Chemical Engineering Journal 2023; 461 doi:10.1016/j.cej.2023.141766
  • Yang Yu, Deng Yu, Shi Xianghui, Liu Lei, Yin Xiaole, Zhao Wanwan, Li Shuxian, Yang Chao, Zhang Tong. QMRA of beach water by Nanopore sequencing-based viability-metagenomics absolute quantification, Water Research 2023; 235 doi:10.1016/j.watres.2023.119858
  • Deng Y, Zheng X, Xu X, Chui HO-KWONG, Lai WAI-KWAN, Li S, Tun HM, Poon LML, Ding J, Peiris JSM, Leung GM, Zhang T. Use of Sewage Surveillance for COVID-19: A Large-Scale Evidence-Based Program in Hong Kong, Environmental Health Perspectives 2022; 130(5) doi:10.1289/EHP9966
  • Deng Y, Xu X, Zheng X, Ding J, Li S, Chui HO-KWONG, Wong TSZ-KIN, Poon LML, Zhang T. Use of sewage surveillance for COVID-19 to guide public health response: A case study in Hong Kong, Science of The Total Environment 2022; 821: 153250-153250 doi:10.1016/j.scitotenv.2022.153250
  • Xu X, Deng Y, Zheng X, Li S, Ding J, Yang Y, On HY, Yang RONG, Chui HO-KWONG, Yau CY, Tun HM, Chin WH, Poon LML, Peiris JSM, Leung GM, Zhang T. Evaluation of RT-qPCR Primer-Probe Sets to Inform Public Health Interventions Based on COVID-19 Sewage Tests, Environmental Science & Technology 2022; 56: 8875-8884 doi:10.1021/acs.est.2c00974
  • Zheng X, Li S, Deng Y, Xu X, Ding J, Lau FTK, Yau CY, Poon LML, Tun HM, Zhang T. Quantification of SARS-CoV-2 RNA in wastewater treatment plants mirrors the pandemic trend in Hong Kong, Science of The Total Environment 2022; 157121-157121 doi:10.1016/j.scitotenv.2022.157121
  • Zheng X, Deng Y, Xu X, Li S, Zhang Y, Ding J, On HY, Lai JCC, Yau CY, Chin WH, Poon LML, Tun HM, Zhang T. Comparison of virus concentration methods and RNA extraction methods for SARS-CoV-2 wastewater surveillance, Science of The Total Environment 2022; 824: 153687-153687 doi:10.1016/j.scitotenv.2022.153687
  • Xu X, Deng Y, Ding J, Zheng X, Li S, Liu L, Chui HO-KWONG, Poon LML, Zhang T. Real-time allelic assays of SARS-CoV-2 variants to enhance sewage surveillance, Water Research 2022; 220: 118686-118686 doi:10.1016/j.watres.2022.118686
  • Zheng X, Li S, Deng Y, Xu X, Ding J, Lau FTK, Yau CY, Poon LML, Tun HM, Zhang T. Quantification of SARS-CoV-2 RNA in wastewater treatment plants mirrors the pandemic trend in Hong Kong, Science of The Total Environment 2022; 844: 157121-157121 doi:10.1016/j.scitotenv.2022.157121
  • Yang Yu, Che You, Liu Lei, Wang Chunxiao, Yin Xiaole, Deng Yu, Yang Chao, Zhang Tong. Rapid absolute quantification of pathogens and ARGs by nanopore sequencing, Science of the Total Environment 2022; 809: article no. 152190-article no. 152190 doi:10.1016/j.scitotenv.2021.152190
  • Liu Lei, Yang Yu, Deng Yu, Zhang Tong. Nanopore long-read-only metagenomics enables complete and high-quality genome reconstruction from mock and complex metagenomes, Microbiome 2022; 10(1) doi:10.1186/s40168-022-01415-8
  • Yin Xiaole, Yang Yu, Deng Yu, Huang Yue, Li Liguan, Chan Lilian Y.L., Zhang Tong. An assessment of resistome and mobilome in wastewater treatment plants through temporal and spatial metagenomic analysis , Water Research 2022; 209 doi:10.1016/j.watres.2021.117885
  • Xu X, Zheng X, Li S, Lam NS, Wang Y, Chu DKW, Poon LLM, Tun HM, Peiris M, Deng Y, Leung GM, Zhang T. The first case study of wastewater-based epidemiology of COVID-19 in Hong Kong, Science of the Total Environment 2021; 790: article no. 148000-article no. 148000 doi:10.1016/j.scitotenv.2021.148000
  • Deng Yu, Huang Yue, Che You, Yang Yu, Yin Xiaole, Yan Aixin, Dai Lei, Liu Yang Yu, Polz Martin, Zhang Tong. Microbiome assembly for sulfonamide subsistence and the transfer of genetic determinants, ISME Journal 2021; 15(10): 2817-2829 doi:10.1038/s41396-021-00969-z
  • Yang Yu, Zhang An Ni, Che You, Liu Lei, Deng Yu, Zhang Tong. Underrepresented high diversity of class 1 integrons in the environment uncovered by PacBio sequencing using a new primer, Science of the Total Environment 2021; 787: article no. 147611-article no. 147611 doi:10.1016/j.scitotenv.2021.147611
  • Huang Qi, Sham Ronia C., Deng Yu, Mao Yanping, Wang Chunxiao, Zhang Tong, Leung Kenneth M.Y.. Diversity of gut microbiomes in marine fishes is shaped by host-related factors, Molecular Ecology 2020; 29(24): 5019-5034 doi:10.1111/mec.15699
  • Deng Y, Wang Y, Xia Y, Zhang AN, Zhao Y, Zhang T. Genomic resolution of bacterial populations in saccharin and cyclamate degradation, Science of the Total Environment 2019; 658: 357-366 doi:10.1016/j.scitotenv.2018.12.162
  • Yin X, Deng Y, Ma L, Wang Y, Chan LYL, Zhang T. Exploration of the antibiotic resistome in a wastewater treatment plant by a nine-year longitudinal metagenomic study, Environment International 2019; 133: article no. 105270-article no. 105270 doi:10.1016/j.envint.2019.105270
  • Cao L, Zhang J, Zhao R, Deng Y, Liu J, Fu W, Lei Y, Zhang T, Li X, Li B. Genomic characterization, kinetics, and pathways of sulfamethazine biodegradation by Paenarthrobacter sp. A01, Environment International 2019; 131: article no. 104961-article no. 104961 doi:10.1016/j.envint.2019.104961
  • Deng Y, Li B, Zhang T. Bacteria That Make a Meal of Sulfonamide Antibiotics: Blind Spots and Emerging Opportunities, Environmental Science & Technology 2018; 52(7): 3854-3868 doi:10.1021/acs.est.7b06026
  • Deng Y, Wang Y, Mao Y, Zhang T. Partnership of Arthrobacter and Pimelobacter in Aerobic Degradation of Sulfadiazine Revealed by Metagenomics Analysis and Isolation, Environmental Science & Technology 2018; 52(5): 2963-2972 doi:10.1021/acs.est.7b05913
  • Guo H, Deng Y, Yao Z, Yang Z, Wang J, Lin C, Zhang T, Zhu B, Tang C. A highly selective surface coating for enhanced membrane rejection of endocrine disrupting compounds: Mechanistic insights and implications, Water Research 2017; 121: 197-203 doi:10.1016/j.watres.2017.05.037
  • Xia Y, Li AD, Deng Y, Jiang XT, Li LG, Zhang T. MinION Nanopore Sequencing Enables Correlation between Resistome Phenotype and Genotype of Coliform Bacteria in Municipal Sewage, Frontiers in Microbiology 2017; 8: article no. 2105-article no. 2105 doi:10.3389/fmicb.2017.02105
  • Wang F, Lu X, Peng W, Deng Y, Zhang T, Hu Y, Li XY. Sorption Behavior of Bisphenol A and Triclosan by Graphene: Comparison with Activated Carbon, ACS Omega 2017; 2(9): 5378-5384 doi:10.1021/acsomega.7b00616
  • Feng Y, Wu D, Deng Y, Zhang T, Shih K. Sulfate Radical-Mediated Degradation of Sulfadiazine by CuFeO2 Rhombohedral Crystal-Catalyzed Peroxymonosulfate: Synergistic Effects and Mechanisms, Environmental Science & Technology 2016; 50(6): 3119-3127 doi:10.1021/acs.est.5b05974
  • Feng Y, Wu D, Liao C, Deng Y, Zhang T, Shih K. Red Mud Powders as Low-Cost and Efficient Catalysts for Persulfate Activation: Pathways and Reusability of Mineralizing Sulfadiazine, Separation and Purification Technology 2016; 167: 136-145 doi:10.1016/j.seppur.2016.04.051
  • Guo F, Li B, Yang Y, Deng Y, Qiu JW, Li X, Leung KMY, Zhang T. Impacts of human activities on distribution of sulfate-reducing prokaryotes and antibiotic resistance genes in marine coastal sediments of Hong Kong, FEMS Microbiology Ecology 2016; 92(9): article no. fiw128-article no. fiw128 doi:10.1093/femsec/fiw128
  • Guo H, Deng Y, Tao Z, Yao Z, Wang J, Lin C, Zhang T, Zhu B, Tang C. Does Hydrophilic Polydopamine Coating Enhance Membrane Rejection of Hydrophobic Endocrine-Disrupting Compounds?, Environmental Science & Technology Letters 2016; 3(9): 332-338 doi:10.1021/acs.estlett.6b00263
  • Deng Y, Li B, Yu K, Zhang T. Biotransformation and adsorption of pharmaceutical and personal care products by activated sludge after correcting matrix effects, Science of The Total Environment 2016; 544: 980-986 doi:10.1016/j.scitotenv.2015.12.010
  • Deng Y, Mao Y, Li B, Yang C, Zhang T. Aerobic Degradation of Sulfadiazine by Arthrobacter spp.: Kinetics, Pathways, and Genomic Characterization, Environmental Science & Technology 2016; 50(17): 9566-9575 doi:10.1021/acs.est.6b02231
  • Feng Y, Liu J, Wu D, Zhou Z, Deng Y, Zhang T, Shih K. Efficient Degradation of Sulfamethazine with CuCo2O4 Spinel Nanocatalysts for Peroxymonosulfate Activation, Chemical Engineering Journal 2015; 280: 514-524 doi:10.1016/j.cej.2015.05.121

    • Show More

    PG Thesis

  • Deng Yu Biodegradation of emerging pollutants and the functional bacteria in the microbial community[PG Thesis]. Pokfulam, Hong Kong: The University of Hong Kong; 2017. doi:10.5353/th_991043979553203414
Honours & Awards
  • 2022. Deng Y. Gold Medals at 2022 Geneva International Exhibition of Inventions.
  • 2021. Deng Y. Chief Executive's Commendation for Community Service.
  • 2021. Deng Y. Gold Medals at 2021 Geneva International Exhibition of Inventions.
Grants
  • Project Title: Examining the role of prophage and plasmid mobilome for strain variation in phage resistance among antibiotic-resistant bacteria
    Grant Type: General Research Fund (GRF) 2025/26
    Funding Year: 2025
    Amount: HK$1,197,277
    Principal Investigator: Professor Deng, Yu
  • Project Title: Utilizing phylogeographic approach for tailored development of therapeutic phages against antibiotic-resistant Klebsiella pneumoniae
    Grant Type: NSFC/RGC Joint Research Scheme 2025/26
    Funding Year: 2025
    Amount: HK$1,218,557
    Principal Investigator: Professor Deng, Yu
  • Project Title: Integrating large-scale bacterial cultivation and advanced genomic techniques to understand active lysogeny in phage-bacteria interactions
    Grant Type: General Research Fund (GRF) 2024/25
    Funding Year: 2024
    Amount: HK$1,062,136
    Principal Investigator: Professor Deng, Yu
    Co-investigator(s): Professor Zhang Tong
  • Project Title: Predicting antimicrobial resistance prevalence in clinically important pathogens using time-series wastewater metagenomic data
    Grant Type: General Research Fund (GRF) 2023/24
    Funding Year: 2023
    Amount: HK$848,595
    Principal Investigator: Professor Deng, Yu
    Co-investigator(s): Professor Zhang Tong
  • Project Title: Strengthening sewage surveillance for SARS-CoV-2
    Grant Type: Commissioned Research on the Novel Coronavirus Disease (COVID-19)
    Funding Year: 2021
    Amount: HK$9,092,120
    Principal Investigator: Professor Zhang, Tong
    Co-investigator(s): Professor Deng Yu, Professor Poon Lit Man Leo, Professor Leung Gabriel Matthew, Dr Tun Hein Min
HKU Committee Appointments
  • 18 December 2023-Present: Faculty of Dentistry, Board of the. The teachers who are members of the Faculty and who are full-time employees of the University

Note

  • All publication and awards data are automatically fetched periodically from the HKU Scholars Hub.