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高鵬

Professor Gao, Peng

BSc(BNU), MMed(PUMC), PhD(HKU)

Professor Gao, Peng 高鵬 - HKU Faculty of Dentistry 香港大學牙醫學院

Profile

Title
  • Assistant Professor
    助理教授
Division
Applied Oral Sciences & Community Dental Care
E-mail
gaopeng@hku.hk
Phone
+852 2859 0494
Research Theme
Microbiome Innovation
Areas of Research Expertise
  • Bacterial Pathogenic Mechanism
  • Biofilm
  • Discovery of Alternative Therapeutics
  • Microbiome and Antibiotic Resistance
  • Phage Engineering
Research Profile
Publication & Awards
Publications

    Article

  • Zhang Jing, Li Dongsheng, Zhou Wenwen, Liu Chao, Wang Peirong, You Baoqing, Su Bingjie, Guo Keyu, Shi Wenjing, Yung Tin Mong Timothy, Kao Richard Yi Tsun, Gao Peng, Li Yan, Si Shuyi. Yeast-two-hybrid based high-throughput screening to discover SARS-CoV-2 fusion inhibitors by targeting the HR1/HR2 interaction, Acta Pharmaceutica Sinica B 2025; doi:10.1016/j.apsb.2025.06.029
  • Ip Tiffany Ka Yan, Wang Yuchuan, Wang Suyu, Pu Keyuan, Wang Runming, Han Bingjie, Gao Peng, Xie Yanxuan, Kao Richard Y., Ho Pak Leung, Li Hongyan, Sun Hongzhe. Hinokitiol potentiates antimicrobial activity of bismuth drugs: a combination therapy for overcoming antimicrobial resistance, RSC Medicinal Chemistry 2025; 16(4): 1829-1841 doi:10.1039/d4md00860j
  • Li Jingru, Wang Haibo, Gao Peng, Wang Runming, Chan Chun Lung, Kao Richard Yi-Tsun, Li Hongyan, Sun Hongzhe. Bismuth drug eradicates multi-drug resistant Burkholderia cepacia complex via aerobic respiration, Chemical Science 2025; 16(27): 12372-12384 doi:10.1039/d5sc02049b
  • Xia Yushan, Wei Xueying, Gao Peng, Wang Chenyuan, De Jong Anne, Chen Jonathan Hon Kwan, Rodríguez-Sánchez María José, Rodríguez-Nogales Alba, Diez-Echave Patricia, Gálvez Julio, García Federico, Wu Weihui, Kao Richard Yi-Tsun, Li Hongyan, Cebrián Rubén, Kuipers Oscar P, Sun Hongzhe. Bismuth-based drugs sensitize Pseudomonas aeruginosa to multiple antibiotics by disrupting iron homeostasis, Nature Microbiology 2024; doi:10.1038/s41564-024-01807-6
  • Gao Peng, Wei Yuanxin, Hou Suying, Lai Pok-Man, Liu Han, Tai Sherlock Shing Chiu, Tang Victor Yat Man, Prakash Pradeep Halebeedu, Sze Kong-Hung, Chen Jonathan Hon Kwan, Sun Hongzhe, Li Xuechen, Kao Richard Yi-Tsun. SaeR as a novel target for antivirulence therapy against Staphylococcus aureus, Emerging Microbes & Infections 2023; 12(2) doi:10.1080/22221751.2023.2254415
  • Iu Ho-Ting-Venice, Fong Pak-Ming, Yam Hin-Cheung-Bill, Gao Peng, Yan Bingpeng, Lai Pok-Man, Tang Victor-Yat-Man, Li Ka-Ho, Ma Chi-Wang, Ng King-Hei-Kenneth, Sze Kong-Hung, Yang Dan, Davies Julian, Kao Richard-Yi-Tsun. Identification of a Small Molecule Compound Active against Antibiotic-Tolerant Staphylococcus aureus by Boosting ATP Synthesis, International Journal of Molecular Sciences 2023; 24(7) doi:10.3390/ijms24076242
  • Gao P, Wei Y, Wan RE, Wong KW, Iu HTV, Tai SCS, Li Y, Yam HCB, Halebeedu Prakash P, Chen HKJ, Ho PL, Yuen KY, Davies J, Kao RYT, Rampioni G. Subinhibitory Concentrations of Antibiotics Exacerbate Staphylococcal Infection by Inducing Bacterial Virulence, Microbiology Spectrum 2022; 10 doi:10.1128/spectrum.00640-22
  • Gao P, Wei Y, Tai SCS, Halebeedu Prakash P, Iu HTV, Li Y, Yam HCB, Chen HKJ, Ho PL, Davies J, Chan JFW. Antivirulence Agent as an Adjuvant of β-Lactam Antibiotics in Treating Staphylococcal Infections, Antibiotics 2022; 11: 819-819 doi:10.3390/antibiotics11060819
  • Yan B, Fung KC, Ye S, Lai PM, Wei Y, Sze KH, Yang D, Gao P, Kao RYT. Linoleic acid metabolism activation in macrophages promotes the clearing of intracellular Staphylococcus aureus , Chemical Science 2022; doi:10.1039/D2SC04307F
  • Zhu L, Lee A, Wu K, Gao P, Tam KGK, Rahim R, Chaburte G, Ng T, Chan C, Lao H, Yam WC, Kao RYT, Siu G. Screening Repurposed Antiviral Small Molecules as Antimycobacterial Compounds by a Lux-Based phoP Promoter-Reporter Platform, Antibiotics 2022; 11: 369-369 doi:10.3390/antibiotics11030369
  • DENG J, Zhang BZ, Chu H, Wang XL, Wang Y, Gong HR, Li R, Yang D, Li C, Dou Y, Gao P, Cai JP, Jin M, Du Q, Chan JFW, Kao RYT, Yuen KY, Huang JD. Adenosine synthase A contributes to recurrent Staphylococcus aureus infection by dampening protective immunity, EBioMedicine 2021; 70: article no. 103505-article no. 103505 doi:10.1016/j.ebiom.2021.103505
  • Wang Haibo, Wang Minji, Xu Xiaohan, Gao Peng, Xu Zeling, Zhang Qi, Li Hongyan, Yan Aixin, Kao Richard Yi Tsun, Sun Hongzhe. Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance, Nature Communications 2021; 12(1): article no. 3331-article no. 3331 doi:10.1038/s41467-021-23659-y
  • Wang Haibo, Wang Minji, Xu Xiaohan, Gao Peng, Xu Zeling, Zhang Qi, Li Hongyan, Yan Aixin, Kao Richard Yi Tsun, Sun Hongzhe. Author Correction: Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance, Nature Communications 2021; 12(1): article no. 4140-article no. 4140 doi:10.1038/s41467-021-24538-2
  • Chow HY, Po KHL, Gao P, Blasco P, Wang X, Li C, Ye L, Jin K, Chen K, Chan EWC, You X, Kao RYT, Chen S, Li X. Methylation of Daptomycin Leading to the Discovery of Kynomycin, a Cyclic Lipodepsipeptide Active against Resistant Pathogens, Journal of Medicinal Chemistry 2020; 63(6): 3161-3171 doi:10.1021/acs.jmedchem.9b01957
  • Meng J, Gao P, Wang X, Guan Y, Liu Y, Xiao C. Digging deeper to save the old anti-tuberculosis target: D-alanine-D-alanine ligase with a novel inhibitor, IMB-0283, Frontiers in Microbiology 2020; 10: article no. 3017-article no. 3017 doi:10.3389/fmicb.2019.03017
  • Shen J, Gao P, Han S, Kao RYT, Wu S, Liu X, Qian S, Chu PK, Cheung KMC, Yeung KWK. A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections, Acta Biomaterialia 2020; 114: 421-430 doi:10.1016/j.actbio.2020.07.040
  • Deng J, Wang X, Zhang BZ, Gao P, Lin Q, Kao RYT, Gustafsson K, Yuen KY, Huang JD. Broad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens, mSphere 2019; 4(5): article no. e00362-19-article no. e00362-19 doi:10.1128/mSphere.00362-19
  • Wang R, Lai TP, Gao P, Zhang HM, Ho PL, Woo PCY, Ma GX, Kao RYT, Li H, Sun H. Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors, Nature Communications 2018; 9: article no. 439-article no. 439 doi:10.1038/s41467-018-02828-6
  • Gao P, Ho PL, Yan B, Sze KH, Davies J, Kao RYT. Suppression of Staphylococcus aureus virulence by a small-molecule compound, Proceedings of the National Academy of Sciences 2018; 115(31): 8003-8008 doi:10.1073/pnas.1720520115
  • Gao P, Davies J, Kao RYT. Dehydrosqualene Desaturase as a Novel Target for Anti-Virulence Therapy against Staphylococcus aureus, mBio 2017; 8(5): article no. e01224-17-article no. e01224-17 doi:10.1128/mBio.01224-17
  • Gao P, Wang Y, Villanueva I, Ho PL, Davies J, Kao RYT. Construction of a Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression and the Identification of Usnic Acid as a Potent Suppressor of psm Gene Expression, Frontiers in Microbiology 2016; 7: article no. 1344-article no. 1344 doi:10.3389/fmicb.2016.01344
  • Hu J, Wong NK, Lu M, Chen X, Ye S, Zhao Q, Gao P, Kao RYT, Shen J, Yang D. HKOCl-3: a fluorescent hypochlorous acid probe for live-cell and in vivo imaging and quantitative application in flow cytometry and a 96-well microplate assay, Chemical Science 2016; 7(3): 2094-2099 doi:10.1039/C5SC03855C
  • Zhao Q, Ding Y, Deng ZS, Lee OY, Gao P, Chen P, Rose RJ, Zhao H, Zhang ZF, Tao X, Heck AJR, Kao RYT, Yang D. Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I, Chemical Science 2015; 6(7): 4124-4130 doi:10.1039/C5SC00633C
  • Gao P, Yang YH, Xiao CL, Liu YS, Gan ML, Guan Y, Hao XQ, Meng JZ, Zhou S, Chen XJ. Identification and validation of a novel lead compound targeting 4-diphosphocytidyl-2-C-methylerythritol synthetase (IspD) of mycobacteria, European Journal of Pharmacology 2012; 694(1-3): 45-52 doi:10.1016/j.ejphar.2012.08.012
  • Yang YH, Gao P, Liu YS, Ji XY, Gan ML, Guan Y, Hao XQ, Li ZR, Xiao CL. A discovery of novel Mycobacterium tuberculosis pantothenate synthetase inhibitors based on the molecular mechanism of actinomycin D inhibition, Bioorganic & Medicinal Chemistry Letters 2011; 21(13): 3943-3946 doi:10.1016/j.bmcl.2011.05.021
  • Gao Peng, Guan Yan, Song Danqing, Xiao Chunling. A cell-based screening system for detection of inhibitors toward mycobacterial cell wall core, Journal of Antibiotics 2009; 62(6): 315-318 doi:10.1038/ja.2009.34
  • Zhang Zhang, Gao Peng, Guan Yan, Xiao Chun Lin, Hao Xue Qin. Isolation, purification, identification of structure and study of bioactivity of anti-TB active component 9005B, Chinese Journal of Antibiotics 2009; 34(7): 399-402
  • Wang Yang, Hao Xue Qin, Gao Peng, Yang Yan Hui, Xiao Chun Ling. Preparation of isocitrate lyase versus etablishment of a drug screening model for isocitrate lyase inhibitors, Chinese Journal of Antibiotics 2009; 34(8): 467-470

    • Show More

    Conference Paper

  • Gao P, Sun H, Davies J, Kao RYT. Alternative strategies to tackle antibiotics resistance, 2018 World Life Science Conference 2018;
  • Kao RYT, Gao P. Identification of anti-virulence compounds for combating Staphylococcus aureus infections by highthroughput screening (HTS), International Conference on Prevention & Infection Control 2017;
  • Gao P, Kao RYT. Disarming the protective pigments of Staphylococcus aureus by a small molecule compound, The Official Conference of the International Chemical Biology Society (ICBS) 2017;
  • Gao P, Wang Y, Villanueva I, Ho PL, Davies J, Kao RYT. Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression, World Life Science Conference, WLSC2016 2016;

    • PG Thesis

  • Gao Peng Small molecule compounds perturbing the virulence of Staphylococcus aureus : a chemical genetics approach[PG Thesis]. Pokfulam, Hong Kong: The University of Hong Kong; 2014. doi:10.5353/th_991044046694903414
Honours & Awards
  • 2024. WEI Xueying, Sun H, Li H, Gao P, Xia Y. Best poster award in the 11th Asian Biological Inorganic Chemistry Conference.
  • 2017. Kao RYT, Gao P. Innovation Academy Award: International Consortium on Prevention and Infection Control (ICPIC).
Professional Societies
  • 12/2012: member. the Hong Kong Society for Infectious Diseases.
  • 09/2017-: member. International Chemical Biology Society (ICBS).
  • 07/2021-: member. American Society for Microbiology.
  • 03/2024-: Guest editor. Antibiotics.
  • 01/2025-: reviewing editor. Microbiology spectrum.
Grants
  • Project Title: Development of Inhibitors Targeting the SaeRS Two-component System of Staphylococcus Aureus
    Grant Type: Guangdong Basic and Applied Basic Research Fund (Guangdong Natural Science Fund) General Programme - 2024
    Funding Year: 2025
    Amount: HK$109,200
    Principal Investigator: Professor Gao, Peng
  • Project Title: Bismuth(III) compounds to enhance antimicrobial activity of multiple antibiotics against Pseudomonas aeruginosa
    Grant Type: General Research Fund (GRF) 2025/26
    Funding Year: 2025
    Amount: HK$1,219,899
    Principal Investigator: Professor Sun, Hongzhe
    Co-investigator(s): Professor Gao Peng
  • Project Title: Exploring Human Microbiota's Biosynthetic Potential for Antimicrobial Discovery
    Grant Type: Collaborative Research Fund (CRF) - Group Research Project 2024/2025
    Funding Year: 2024
    Amount: HK$6,818,584
    Principal Investigator: Professor Li, Yongxin Philip
    Co-principal investigator(s): Professor Gao Peng, Professor Li Xuechen
  • Project Title: Decrypting the mechanism of anti-virulence compound HR3744 against MRSA by targeting the response regulator SaeR
    Grant Type: Health and Medical Research Fund - Full Grant
    Funding Year: 2019
    Amount: HK$1,349,656
    Principal Investigator: Professor Gao, Peng
    Co-investigator(s): Professor Li Xuechen, Professor Kao Richard Yi Tsun, Professor Hao Quan, Dr Sze Kong Hung
Invited Lectures & Keynote Speeches
  • 14 December 2023: SaeRS mediated staphylococcal biofilm formation on biotic surface. .
HKU Committee Appointments
  • 11 March 2024-Present: Faculty of Dentistry, Board of the. The teachers who are members of the Faculty and who are full-time employees of the University

Note

  • All publication and awards data are automatically fetched periodically from the HKU Scholars Hub.