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高鵬

Professor Gao, Peng

BSc(BNU), MMed(PUMC), PhD(HKU)

Profile

Title
  • Assistant Professor
    助理教授
Division
Applied Oral Sciences & Community Dental Care
E-mail
gaopeng@hku.hk
Phone
+852 2859 0494
Research Theme
Microbiome Innovation
Areas of Research Expertise
  • Bacterial Pathogenic Mechanism
  • Biofilm
  • Discovery of Alternative Therapeutics
  • Microbiome and Antibiotic Resistance
  • Phage Engineering
Research Profile
Publication & Awards
Publications

    Article

  • Gao Peng, Wei Yuanxin, Hou Suying, Lai Pok-Man, Liu Han, Tai Sherlock Shing Chiu, Tang Victor Yat Man, Prakash Pradeep Halebeedu, Sze Kong-Hung, Chen Jonathan Hon Kwan, Sun Hongzhe, Li Xuechen, Kao Richard Yi-Tsun. SaeR as a novel target for antivirulence therapy against Staphylococcus aureus, Emerging Microbes & Infections 2023; 12(2) doi:10.1080/22221751.2023.2254415
  • Iu Ho-Ting-Venice, Fong Pak-Ming, Yam Hin-Cheung-Bill, Gao Peng, Yan Bingpeng, Lai Pok-Man, Tang Victor-Yat-Man, Li Ka-Ho, Ma Chi-Wang, Ng King-Hei-Kenneth, Sze Kong-Hung, Yang Dan, Davies Julian, Kao Richard-Yi-Tsun. Identification of a Small Molecule Compound Active against Antibiotic-Tolerant Staphylococcus aureus by Boosting ATP Synthesis, International Journal of Molecular Sciences 2023; 24(7) doi:10.3390/ijms24076242
  • Gao P, Wei Y, Wan RE, Wong KW, Iu HTV, Tai SCS, Li Y, Yam HCB, Halebeedu Prakash P, Chen HKJ, Ho PL, Yuen KY, Davies J, Kao RYT, Rampioni G. Subinhibitory Concentrations of Antibiotics Exacerbate Staphylococcal Infection by Inducing Bacterial Virulence, Microbiology Spectrum 2022; 10 doi:10.1128/spectrum.00640-22
  • Gao P, Wei Y, Tai SCS, Halebeedu Prakash P, Iu HTV, Li Y, Yam HCB, Chen HKJ, Ho PL, Davies J, Chan JFW. Antivirulence Agent as an Adjuvant of β-Lactam Antibiotics in Treating Staphylococcal Infections, Antibiotics 2022; 11: 819-819 doi:10.3390/antibiotics11060819
  • Yan B, Fung KC, Ye S, Lai PM, Wei Y, Sze KH, Yang D, Gao P, Kao RYT. Linoleic acid metabolism activation in macrophages promotes the clearing of intracellular Staphylococcus aureus , Chemical Science 2022; doi:10.1039/D2SC04307F
  • Zhu L, Lee A, Wu K, Gao P, Tam KGK, Rahim R, Chaburte G, Ng T, Chan C, Lao H, Yam WC, Kao RYT, Siu G. Screening Repurposed Antiviral Small Molecules as Antimycobacterial Compounds by a Lux-Based phoP Promoter-Reporter Platform, Antibiotics 2022; 11: 369-369 doi:10.3390/antibiotics11030369
  • DENG J, Zhang BZ, Chu H, Wang XL, Wang Y, Gong HR, Li R, Yang D, Li C, Dou Y, Gao P, Cai JP, Jin M, Du Q, Chan JFW, Kao RYT, Yuen KY, Huang JD. Adenosine synthase A contributes to recurrent Staphylococcus aureus infection by dampening protective immunity, EBioMedicine 2021; 70: article no. 103505-article no. 103505 doi:10.1016/j.ebiom.2021.103505
  • Wang Haibo, Wang Minji, Xu Xiaohan, Gao Peng, Xu Zeling, Zhang Qi, Li Hongyan, Yan Aixin, Kao Richard Yi Tsun, Sun Hongzhe. Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance, Nature Communications 2021; 12(1): article no. 3331-article no. 3331 doi:10.1038/s41467-021-23659-y
  • Wang Haibo, Wang Minji, Xu Xiaohan, Gao Peng, Xu Zeling, Zhang Qi, Li Hongyan, Yan Aixin, Kao Richard Yi Tsun, Sun Hongzhe. Author Correction: Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance, Nature Communications 2021; 12(1): article no. 4140-article no. 4140 doi:10.1038/s41467-021-24538-2
  • Chow HY, Po KHL, Gao P, Blasco P, Wang X, Li C, Ye L, Jin K, Chen K, Chan EWC, You X, Kao RYT, Chen S, Li X. Methylation of Daptomycin Leading to the Discovery of Kynomycin, a Cyclic Lipodepsipeptide Active against Resistant Pathogens, Journal of Medicinal Chemistry 2020; 63(6): 3161-3171 doi:10.1021/acs.jmedchem.9b01957
  • Meng J, Gao P, Wang X, Guan Y, Liu Y, Xiao C. Digging deeper to save the old anti-tuberculosis target: D-alanine-D-alanine ligase with a novel inhibitor, IMB-0283, Frontiers in Microbiology 2020; 10: article no. 3017-article no. 3017 doi:10.3389/fmicb.2019.03017
  • Shen J, Gao P, Han S, Kao RYT, Wu S, Liu X, Qian S, Chu PK, Cheung KMC, Yeung KWK. A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections, Acta Biomaterialia 2020; 114: 421-430 doi:10.1016/j.actbio.2020.07.040
  • Deng J, Wang X, Zhang BZ, Gao P, Lin Q, Kao RYT, Gustafsson K, Yuen KY, Huang JD. Broad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens, mSphere 2019; 4(5): article no. e00362-19-article no. e00362-19 doi:10.1128/mSphere.00362-19
  • Wang R, Lai TP, Gao P, Zhang HM, Ho PL, Woo PCY, Ma GX, Kao RYT, Li H, Sun H. Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors, Nature Communications 2018; 9: article no. 439-article no. 439 doi:10.1038/s41467-018-02828-6
  • Gao P, Ho PL, Yan B, Sze KH, Davies J, Kao RYT. Suppression of Staphylococcus aureus virulence by a small-molecule compound, Proceedings of the National Academy of Sciences 2018; 115(31): 8003-8008 doi:10.1073/pnas.1720520115
  • Gao P, Davies J, Kao RYT. Dehydrosqualene Desaturase as a Novel Target for Anti-Virulence Therapy against Staphylococcus aureus, mBio 2017; 8(5): article no. e01224-17-article no. e01224-17 doi:10.1128/mBio.01224-17
  • Gao P, Wang Y, Villanueva I, Ho PL, Davies J, Kao RYT. Construction of a Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression and the Identification of Usnic Acid as a Potent Suppressor of psm Gene Expression, Frontiers in Microbiology 2016; 7: article no. 1344-article no. 1344 doi:10.3389/fmicb.2016.01344
  • Hu J, Wong NK, Lu M, Chen X, Ye S, Zhao Q, Gao P, Kao RYT, Shen J, Yang D. HKOCl-3: a fluorescent hypochlorous acid probe for live-cell and in vivo imaging and quantitative application in flow cytometry and a 96-well microplate assay, Chemical Science 2016; 7(3): 2094-2099 doi:10.1039/C5SC03855C
  • Zhao Q, Ding Y, Deng ZS, Lee OY, Gao P, Chen P, Rose RJ, Zhao H, Zhang ZF, Tao X, Heck AJR, Kao RYT, Yang D. Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I, Chemical Science 2015; 6(7): 4124-4130 doi:10.1039/C5SC00633C
  • Gao P, Yang YH, Xiao CL, Liu YS, Gan ML, Guan Y, Hao XQ, Meng JZ, Zhou S, Chen XJ. Identification and validation of a novel lead compound targeting 4-diphosphocytidyl-2-C-methylerythritol synthetase (IspD) of mycobacteria, European Journal of Pharmacology 2012; 694(1-3): 45-52 doi:10.1016/j.ejphar.2012.08.012
  • Yang YH, Gao P, Liu YS, Ji XY, Gan ML, Guan Y, Hao XQ, Li ZR, Xiao CL. A discovery of novel Mycobacterium tuberculosis pantothenate synthetase inhibitors based on the molecular mechanism of actinomycin D inhibition, Bioorganic & Medicinal Chemistry Letters 2011; 21(13): 3943-3946 doi:10.1016/j.bmcl.2011.05.021
  • Gao Peng, Guan Yan, Song Danqing, Xiao Chunling. A cell-based screening system for detection of inhibitors toward mycobacterial cell wall core, Journal of Antibiotics 2009; 62(6): 315-318 doi:10.1038/ja.2009.34
  • Zhang Zhang, Gao Peng, Guan Yan, Xiao Chun Lin, Hao Xue Qin. Isolation, purification, identification of structure and study of bioactivity of anti-TB active component 9005B, Chinese Journal of Antibiotics 2009; 34(7): 399-402
  • Wang Yang, Hao Xue Qin, Gao Peng, Yang Yan Hui, Xiao Chun Ling. Preparation of isocitrate lyase versus etablishment of a drug screening model for isocitrate lyase inhibitors, Chinese Journal of Antibiotics 2009; 34(8): 467-470

    • Show More

    Conference Paper

  • Gao P, Sun H, Davies J, Kao RYT. Alternative strategies to tackle antibiotics resistance, 2018 World Life Science Conference 2018;
  • Kao RYT, Gao P. Identification of anti-virulence compounds for combating Staphylococcus aureus infections by highthroughput screening (HTS), International Conference on Prevention & Infection Control 2017;
  • Gao P, Kao RYT. Disarming the protective pigments of Staphylococcus aureus by a small molecule compound, The Official Conference of the International Chemical Biology Society (ICBS) 2017;
  • Gao P, Wang Y, Villanueva I, Ho PL, Davies J, Kao RYT. Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression, World Life Science Conference, WLSC2016 2016;

    • PG Thesis

  • Gao Peng Small molecule compounds perturbing the virulence of Staphylococcus aureus : a chemical genetics approach[PG Thesis]. Pokfulam, Hong Kong: The University of Hong Kong; 2014. doi:10.5353/th_991044046694903414
Honours & Awards
  • 2017. Kao RYT, Gao P. Innovation Academy Award: International Consortium on Prevention and Infection Control (ICPIC).
Grants
  • Project Title: Decrypting the mechanism of anti-virulence compound HR3744 against MRSA by targeting the response regulator SaeR
    Grant Type: Health and Medical Research Fund - Full Grant
    Funding Year: 2019
    Amount: HK$1,349,656
    Principal Investigator: Dr Gao, Peng
    Co-investigator(s): Dr Kao Richard Yi Tsun, Professor Li Xuechen, Professor Hao Quan, Dr Sze Kong Hung
HKU Committee Appointments
  • 11 March 2024-Present: Faculty of Dentistry, Board of the. The teachers who are members of the Faculty and who are full-time employees of the University

Note

  • All publication and awards data are automatically fetched periodically from the HKU Scholars Hub.