Profile
Applied Oral Sciences & Community Dental Care
+852 2859 0589
Professor Gao Zhang is an Associate Professor at the Faculty of Dentistry, The University of Hong Kong. He holds a Ph.D. in Bioengineering from the University of Pennsylvania and has undergone advanced training in Genomics, Computational Biology, and Information Technology. Professor Zhang's research focuses on cancer genomics, systems biology, therapeutic resistance, cancer immunology, and brain metastasis. Previously, he served as an Assistant Professor at Duke University, contributing significantly to the Neuro-Oncology Program. He has authored numerous high-impact publications and received several prestigious awards, including the Joanna M. Nicolay Melanoma Foundation's Research Scholarship Award. Professor Zhang is actively involved in academic service, grant reviewing, and mentoring, playing a pivotal role in nurturing future researchers. Recognized among the top 1% of scholars at HKU, his work continues to advance cancer research and therapeutic strategies.
Oral Cancer
- Cancer Genomics
- Systems Biology
- Bioinformatics
- Cancer Therapies
Article
- Zeng Liang, Yan Huan, Jiang Wenjuan, Qin Haoyue, Dai Jiacheng, Zhang Yuda, Wei Shiyou, Chen Shanmei, Liu Li, Xiong Yi, Yang Haiyan, Li Yizhi, Wang Zhan, Deng Li, Xu Qinqin, Peng Ling, Zhang Ruiguang, Fang Chao, Chen Xue, Deng Jun, Wang Jing, Li Ting, Liu Hong, Zhang Gao, Yang Nong, Zhang Yongchang. Toripalimab plus platinum-doublet chemotherapy as perioperative therapy for initially unresectable NSCLC: An open-label, phase 2 trial, Med 2025;
- Liu Y, Yang Z, Pu JJ, Zhong J, Khoo US, Su YX, Zhang G. Proteogenomic characterisation of primary oral cancer unveils extracellular matrix remodelling and immunosuppressive microenvironment linked to lymph node metastasis, Clinical and Translational Medicine 2025; 15(3)
- Zhang Wei, Li Jin-Bang, Liu Hai-Ming, Wang Kui-Ming, Xiao Bo-Lin, Wang Yi-Man, Liang Jia-Jie, Zeng Jun, Zhang Lin-Zhou, Feng Yang-Ying-Fan, Fu Qiu-Yun, Wang Xin-Xin, Liu Yu-Tong, Cheng Xiao-Xia, Li Jing, Zhang Yu-Ying, Zhang Gao, Zhang Jia-Li, Yu Zi-Li, Shao Zhe, Xiong Xue-Peng, Jia Jun, Liu Bing, Chen Gang. PERK+ macrophages drive immunotherapy resistance in lymph node metastases of oral squamous cell carcinoma, Clinical Cancer Research 2025;
- Ruan Zhaohui, Zeng Liang, Zhang Jin, Qin Haoyue, Huang Zhe, Yan Huan, Zhang Gao, Zhang Yongchang. Intrathecal nivolumab and IL-2 for treatment of leptomeningeal metastases in EGFR-mutated lung adenocarcinoma, Lung Cancer 2025; 204
- Hou Da-Yong, Li Xiang-Peng, Wang Yue-Ze, Zhang Peng, Wu Jiong-Cheng, You Hui-Hui, Lv Mei-Yu, Zhou Shi-An, Liu Xiao, Zhang Gao, An Hong-Wei, Wang Hao, Xu Wanhai
. Translational Contrast Agents for Use in Fluorescence Image-Guided Tumor Surgery, Biomaterials 2025; 325
- Kishan Ravi, Zhang Gao, Yang Weifa, Su Yuxiong. Bioinformatics Screening of Tumor-Derived Neuropeptides Mediating Neuroimmune Axis of Head and Neck Cancer, Cancers 2025; 17(15)
- Zeng Liang, Tong Fan, Xu Xingxiang, Song Lianxi, Xue Shidong, Zou Jie, Qiu Bo, Mao Weidong, Liu Hailong, Zhang Bing, Rong Feng, Sun Jun, Xie Hua, Jiang Yongqian, Jiang Wenjuan, Wang Zhan, Zhang Sheng, Zhang Ruiguang, Chen Lingjuan, Zhu Yongqiang, Shang Minghong, Chen Rongzhen, Zhang Gao, Li Ting, Wang Fuyan, Dong Xiaorong, Yang Nong, Zhang Yongchang. Comprehensive first-in-human phase I/II study of FHND-9041 in patients with EGFR-mutated advanced non-small cell lung cancer, Lung Cancer 2025; 207
- Tao Zhuo-Ying, Wang Leilei, Zhu Wang-Yong, Zhang Gao, Su Yu-Xiong. Lingual Denervation Improves the Efficacy of Anti-PD-1 Immunotherapy in Oral Squamous Cell Carcinomas by Downregulating TGFβ Signaling, Cancer Research Communications 2024; 4(2): 418-430
- Yan Huan, Song Lianxi, Li Yizhi, Xu Qinqin, Guo Wenhuan, Lin Shaoding, Jiang Wenjuan, Wang Zhan, Deng Li, Huang Zhe, Qin Haoyue, Zhang Xing, Tong Fan, Zhang Ruiguang, Liu Zhaoyi, Zhang Lin, Yu Juan, Dong Xiaorong, Gong Qian, Deng Jun, Chen Xue, Wang Jing, Zhang Gao, Yang Nong, Zhang Yongchang, Zeng Liang. Clinical evidence for efficacy of pembrolizumab in MSI-H and TMB-H advanced solid tumor: results from three cancer centers in China, Cancer Immunology, Immunotherapy 2024; 73
- Hariharan Seethalakshmi, Whitfield Benjamin T, Pirozzi Christopher J, Waitkus Matthew S, Brown Michael C, Bowie Michelle L, Irvin David M, Roso Kristen, Fuller Rebecca, Hostettler Janell, Dharmaiah Sharvari, Gibson Emiley A, Briley Aaron, Mangoli Avani, Fraley Casey, Shobande Mariah, Stevenson Kevin, Zhang Gao, Malgulwar Prit Benny, Roberts Hannah, Roskoski Martin, Spasojevic Ivan, Keir Stephen T, He Yiping, Castro Maria G, Huse Jason T, Ashley David M. Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas, Nature Communications 2024; 15(1)
- Huang Zhe, Zhang Yuda, Xu Qinqin, Song Lianxi, Li Yizhi, Guo Wenhuan, Lin Shaoding, Jiang Wenjuan, Wang Zhan, Deng Li, Qin Haoyue, Zhang Xing, Tong Fan, Zhang Ruiguang, Liu Zhaoyi, Zhang Lin, Yu Juan, Dong Xiaorong, Gong Qian, Deng Jun, Chen Xue, Wang Jing, Zhang Gao, Yang Nong, Zeng Liang, Zhang Yongchang. Clinical treatment patterns, molecular characteristics and survival outcomes of ROS1-rearranged non-small cell lung cancer: A large multicenter retrospective study, Lung Cancer 2024; 192
- Zou Yunzhi, Duan Hao, Deng Zekun, Xiang Rong, Zhao Jixiang, Zhang Zhenhua, Hu Wanming, Yang Yuanzhong, Yan Zeming, Wen Shujuan, Liu Zexian, Zhang Gao, Mou Yonggao, Li Depei, Jiang Xiaobing. Single-cell atlas profiling revealed cellular characteristics and dynamic changes after PD-1 blockade therapy of brain metastases from laryngeal squamous cell carcinoma, Molecular and Cellular Biochemistry 2024;
- Hu Binbin, Liu Guihong, Zhao Kejia, Zhang Gao. Diversity of extracellular HSP70 in cancer: advancing from a molecular biomarker to a novel therapeutic target, Frontiers in Oncology 2024; 14
- Deng Yulan, Xia Liang, Zhang Jian, Deng Senyi, Wang Mengyao, Wei Shiyou, Li Kaixiu, Lai Hongjin, Yang Yunhao, Bai Yuquan, Liu Yongcheng, Luo Lanzhi, Yang Zhenyu, Chen Yaohui, Kang Ran, Gan Fanyi, Pu Qiang, Mei Jiandong, Ma Lin, Lin Feng, Guo Chenglin, Liao Hu, Zhu Yunke, Liu Zheng, Liu Chengwu, Hu Yang, Yuan Yong, Zha Zhengyu, Yuan Gang, Zhang Gao, Chen Luonan, Cheng Qing, Shen Shensi, Liu Lunxu. Multicellular ecotypes shape progression of lung adenocarcinoma from ground-glass opacity toward advanced stages, Cell Reports Medicine 2024; 5(4)
- Duan Hao, Xie Yuan, Wu Suwen, Zhao Guangyin, Zeng Zhen, Hu Hongrong, Yu Yanjiao, Hu Wanming, Yang Yuanzhong, Chen Yukun, Xie Haoqun, Chen Zexin, Zhang Gao, Flaherty Keith T., Hu Shanshan, Xu Haineng, Ma Wenjuan, Mou Yonggao. Effect of the mRNA decapping enzyme scavenger (DCPS) inhibitor RG3039 on glioblastoma, Journal of Translational Medicine 2024; 22(1)
- Duan Hao, Ren Jianlan, Wei Shiyou, Yang Zhenyu, Li Chuan, Wang Zhenning, Li Meichen, Wei Zhi, Liu Yu, Wang Xiuqi, Lan Hongbin, Zeng Zhen, Xie Maodi, Xie Yuan, Wu Suwen, Hu Wanming, Guo Chengcheng, Zhang Xiangheng, Liang Lun, Yu Chengwei, Mou Yanhao, Jiang Yu, Li Houde, Sugarman Eric, Deek Rebecca A, Chen Zexin, Li Tao, Chen Yaohui, Yao Maojin, Chen Likun, Liu Lunxu, Zhang Gao, Mou Yonggao
. Integrated analyses of multi-omic data derived from paired primary lung cancer and brain metastasis reveal the metabolic vulnerability as a novel therapeutic target, Genome Medicine 2024; 16(1)
- Zhu Qinghai, Tang Yuting, Zhou Tian, Yang Li, Zhang Gao, Meng Ying, Zhang Huixin, Gao Jun, Wang Chenxing, Su Yu-Xiong, Ye Jinhai. Exosomes derived from mesenchymal stromal cells promote bone regeneration by delivering miR-182–5p-inhibitor, Pharmacological Research 2023; 192
- Tang Yuting, Zhu Qinghai, Yang Li, Meng Ying, Zhang Gao, Zhou Tian, Wang Chenxing, Song Xiaomeng, Su Yu-Xiong, Ye Jinhai. MiR-200b-5p inhibits tumor progression in salivary adenoid cystic carcinoma via targeting BTBD1, Cellular Signalling 2023; 109
- Li Fali, Zhang Shu, Jiang Lin, Duan Keyi, Feng Rui, Zhang Yingli, Zhang Gao, Zhang Yangsong, Li Peiyang, Yao Dezhong, Xie Jiang, Xu Wenming, Xu Peng. Recognition of autism spectrum disorder in children based on electroencephalogram network topology, Cognitive Neurodynamics 2023;
- Jiang Y, Yang JL, Liang RC, Zan X, Fan RR, Shan BY, Liu H, Li L, Wang Y, Wu M, Qi X, Chen HX, Ren QQ, Liu ZY, Wang YL, Zhang J, Zhou PZ, Li Q, Tian M, Yang JH, Wang CY, Li XY, Jiang S, Zhou LX, Zhang G, Chen YH, Xu JG. Single-cell RNA sequencing highlights intratumor heterogeneity and intercellular network featured in adamantinomatous craniopharyngioma, Science Advances 2023; 9(15)
- Zhou Guanyu, Pu Yi, Zhao Kejia, Chen Yaohui, Zhang Gao. Heat Shock Proteins in Non-Small-Cell Lung Cancer—Functional Mechanism, Frontiers in Bioscience-Landmark 2023; 28(3)
- Yang Yuanfan, Brown Michael, Zhang Gao, Stevenson Kevin, Mohme Malte, Kornahrens Reb, Bigner Darell, Ashley David, López Giselle, Gromeier Matthias. Polio virotherapy targets the malignant glioma myeloid infiltrate with diffuse microglia activation engulfing the CNS, Neuro-Oncology 2023; 25(9): 1631-1643
- Sun Y, Revach OY, Anderson S, Kessler EA, Wolfe CH, Jenney A, Mills CE, Robitschek EJ, Davis TGR, Kim S, Fu AMA, Ma X, Gwee J, Tiwari P, Du PP, Sindurakar P, Tian J, Mehta A, Schneider AM, Yizhak K, Sade-Feldman M, LaSalle T, Sharova T, Xie HY, Liu SM, Michaud WA, Saad-Beretta R, Yates KB, Iracheta-Vellve A, Spetz JKE, Qin XP, Sarosiek KA, Zhang G, Kim JW, Su MY, Cicerchia AM, Rasmussen MQ, Klempner SJ, Juric D, Pai SI, Miller DM, Giobbie-Hurder A, Chen JH, Pelka K, Frederick DT, Stinson S, Ivanova E, Aref AR, Paweletz CP, Barbie DA, Sen DR, Fisher DE, Corcoran RB, Hacohen N, Sorger PK, Flaherty KT, Boland GM, Manguso RT, Jenkins RW. Targeting TBK1 to overcome resistance to cancer immunotherapy, Nature 2023; 615(7950): 158-167
- Zhang Lingyun, Jiang Yu, Zhang Gao, Wei Shiyou. The diversity and dynamics of tumor-associated macrophages in recurrent glioblastoma, Frontiers in Immunology 2023; 14
- Wei Shiyou, Yin Delong, Yu Shengnan, Lin Xiang, Savani Milan R., Du Kuang, Ku Yin, Wu Di, Li Shasha, Liu Hao, Tian Meng, Chen Yaohui, Bowie Michelle, Hariharan Seethalakshmi, Waitkus Matthew, Keir Stephen T., Sugarman Eric T., Deek Rebecca A., Labrie Marilyne, Khasraw Mustafa, Lu Yiling, Mills Gordon B., Herlyn Meenhard, Wu Kongming, Liu Lunxu, Wei Zhi, Flaherty Keith T., Abdullah Kalil, Zhang Gao, Ashley David M.. Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas, Clinical Cancer Research 2022; 28(10): 2180-2195
- Abdullah Kalil G., Bird Cylaina E., Buehler Joseph D., Gattie Lauren C., Savani Milan R., Sternisha Alex C., Xiao Yi, Levitt Michael M., Hicks William H., Li Wenhao, Ramirez Denise M.O., Patel Toral, Garzon-Muvdi Tomas, Barnett Samuel, Zhang Gao, Ashley David M., Hatanpaa Kimmo J., Richardson Timothy E., McBrayer Samuel K.. Establishment of patient-derived organoid models of lower-grade glioma, Neuro-Oncology 2022; 24(4): 612-623
- Zhang Jian, Li Houde, Liu Yu, Zhao Kejia, Wei Shiyou, Sugarman Eric T, Liu Lunxu, Zhang Gao. Targeting HSP90 as a Novel Therapy for Cancer: Mechanistic Insights and Translational Relevance, Cells 2022; 11(18)
- Gromeier Matthias, Brown Michael C., Zhang Gao, Lin Xiang, Chen Yeqing, Wei Zhi, Beaubier Nike, Yan Hai, He Yiping, Desjardins Annick, Herndon James E., Varn Frederick S., Verhaak Roel G., Zhao Junfei, Bolognesi Dani P., Friedman Allan H., Friedman Henry S., McSherry Frances, Muscat Andrea M., Lipp Eric S., Nair Smita K., Khasraw Mustafa, Peters Katherine B., Randazzo Dina, Sampson John H., McLendon Roger E., Bigner Darell D., Ashley David M.. Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy, Nature Communications 2021; 12(1): article no. 352-article no. 352
- Liu David, Lin Jia Ren, Robitschek Emily J., Kasumova Gyulnara G., Heyde Alex, Shi Alvin, Kraya Adam, Zhang Gao, Moll Tabea, Frederick Dennie T., Chen Yu An, Wang Shu, Schapiro Denis, Ho Li Lun, Bi Kevin, Sahu Avinash, Mei Shaolin, Miao Benchun, Sharova Tatyana, Alvarez-Breckenridge Christopher, Stocking Jackson H., Kim Tommy, Fadden Riley, Lawrence Donald, Hoang Mai P., Cahill Daniel P., Malehmir Mohsen, Nowak Martin A., Brastianos Priscilla K., Lian Christine G., Ruppin Eytan, Izar Benjamin, Herlyn Meenhard, Van Allen Eliezer M., Nathanson Katherine, Flaherty Keith T., Sullivan Ryan J., Kellis Manolis, Sorger Peter K., Boland Genevieve M.. Evolution of delayed resistance to immunotherapy in a melanoma responder, Nature Medicine 2021; 27(6): 985-992
- Wang Beike, Zhang Wei, Zhang Gao, Kwong Lawrence, Lu Hezhe, Tan Jiufeng, Sadek Norah, Xiao Min, Zhang Jie, Labrie Marilyne, Randell Sergio, Beroard Aurelie, Sugarman Eric, Rebecca Vito W., Wei Zhi, Lu Yiling, Mills Gordon B., Field Jeffrey, Villanueva Jessie, Xu Xiaowei, Herlyn Meenhard, Guo Wei. Targeting mTOR signaling overcomes acquired resistance to combined BRAF and MEK inhibition in BRAF-mutant melanoma, Oncogene 2021; 40(37): 5590-5599
- Du Kuang, Wei Shiyou, Wei Zhi, Frederick Dennie T., Miao Benchun, Moll Tabea, Tian Tian, Sugarman Eric, Gabrilovich Dmitry I., Sullivan Ryan J., Liu Lunxu, Flaherty Keith T., Boland Genevieve M., Herlyn Meenhard, Zhang Gao. Pathway signatures derived from on-treatment tumor specimens predict response to anti-PD1 blockade in metastatic melanoma, Nature Communications 2021; 12(1): article no. 6023-article no. 6023
- Liu Jianglan, Rebecca Vito W., Kossenkov Andrew V., Connelly Thomas, Liu Qin, Gutierrez Alexis, Xiao Min, Li Ling, Zhang Gao, Samarkina Anastasia, Zayasbazan Delaine, Zhang Jie, Cheng Chaoran, Wei Zhi, Alicea Gretchen M., Fukunaga-Kalabis Mizuho, Krepler Clemens, Aza-Blanc Pedro, Yang Chih Cheng, Delvadia Bela, Tong Cynthia, Huang Ye, Delvadia Maya, Morias Alice S., Sproesser Katrin, Brafford Patricia, Wang Joshua X., Beqiri Marilda, Somasundaram Rajasekharan, Vultur Adina, Hristova Denitsa M., Wu Lawrence W., Lu Yiling, Mills Gordon B., Xu Wei, Karakousis Giorgos C., Xu Xiaowei, Schuchter Lynn M., Mitchell Tara C., Amaravadi Ravi K., Kwong Lawrence N., Frederick Dennie T., Boland Genevieve M., Salvino Joseph M., Speicher David W., Flaherty Keith T., Ronai Ze'ev A., Herlyn Meenhard. Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance, Cancer Research 2021; 81(20): 5230-5241
- Wang Huaishan, Chen Hui, Liu Shujing, Zhang Jie, Lu Hezhe, Somasundaram Rajasekharan, Choi Robin, Zhang Gao, Ou Lingling, Scholler John, Tian Shifu, Dong Liyun, Yeye Guo, Huang Lili, Connelly Thomas, Li Ling, Huang Alexander, Mitchell Tara C., Fan Yi, June Carl H., Mills Gordon B., Guo Wei, Herlyn Meenhard, Xu Xiaowei. Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function, Journal for ImmunoTherapy of Cancer 2021; 9(12): article no. e003339-article no. e003339
- Yu Shengnan, Wei Shiyou, Savani Milan, Lin Xiang, Du Kuang, Mender Ilgen, Siteni Silvia, Vasilopoulos Themistoklis, Reitman Zachary J., Ku Yin, Wu Di, Liu Hao, Tian Meng, Chen Yaohui, Labrie Marilyne, Charbonneau Casey M., Sugarman Eric, Bowie Michelle, Hariharan Seethalakshmi, Waitkus Matthew, Jiang Wen, McLendon Roger E., Pan Edward, Khasraw Mustafa, Walsh Kyle M., Lu Yiling, Herlyn Meenhard, Mills Gordon, Herbig Utz, Wei Zhi, Keir Stephen T., Flaherty Keith, Liu Lunxu, Wu Kongming, Shay Jerry W., Abdullah Kalil, Zhang Gao, Ashley David M.. A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas, Clinical Cancer Research 2021; 27(24): 6800-6814
- Wang Liangliang, Gao Yan, Zhang Gao, Li Dan, Wang Zhenda, Zhang Jie, Hermida Leandro C., He Lei, Wang Zhisong, Si Jingwen, Geng Shuang, Ai Rizi, Ning Fei, Cheng Chaoran, Deng Haiteng, Dimitrov Dimiter S., Sun Yan, Huang Yanyi, Wang Dong, Hu Xiaoyu, Wei Zhi, Wang Wei, Liao Xuebin. Enhancing KDM5A and TLR activity improves the response to immune checkpoint blockade, Science Translational Medicine 2020; 12(560): article no. eaax2282-article no. eaax2282
- Lazar Ikrame, Fabre Bertrand, Feng Yongmei, Khateb Ali, Turko Patrick, Martinez Gomez Julia M., Frederick Dennie T., Levesque Mitchell P., Feld Lea, Zhang Gao, Zhang Tongwu, James Brian, Shklover Jeny, Avitan-Hersh Emily, Livneh Ido, Scortegagna Marzia, Brown Kevin, Larsson Ola, Topisirovic Ivan, Wolfenson Haguy, Herlyn Meenhard, Flaherty Keith, Dummer Reinhard, Ronai Zeev A.. SPANX control of lamin A/C modulates nuclear architecture and promotes melanoma growth, Molecular Cancer Research 2020; 18(10): 1560-1573
- Marusak Charles, Thakur Varsha, Li Yuan, Freitas Juliano T., Zmina Patrick M., Thakur Vijay S., Chang Mayland, Gao Ming, Tan Jiufeng, Xiao Min, Lu Yiling, Mills Gordon B., Flaherty Keith, Frederick Dennie T., Miao Benchun, Sullivan Ryan J., Moll Tabea, Boland Genevieve M., Herlyn Meenhard, Zhang Gao, Bedogni Barbara. Targeting extracellular matrix remodeling restores BRAF inhibitor sensitivity in BRAFi-resistant melanoma, Clinical Cancer Research 2020; 26(22): 6039-6050
- Yu Shengnan, Zhang Gao. EFCC1 as a putative prognostic biomarker in lung adenocarcinoma, Annals of Translational Medicine 2020; 8(16)
- Lu Hezhe, Liu Shujing, Zhang Gao, Wu Bin, Zhu Yueyao, Frederick Dennie T., Hu Yi, Zhong Wenqun, Randell Sergio, Sadek Norah, Zhang Wei, Chen Gang, Cheng Chaoran, Zeng Jingwen, Wu Lawrence W., Zhang Jie, Liu Xiaoming, Xu Wei, Krepler Clemens, Sproesser Katrin, Xiao Min, Miao Benchun, Liu Jianglan, Song Claire D., Liu Jephrey Y., Karakousis Giorgos C., Schuchter Lynn M., Lu Yiling, Mills Gordon, Cong Yusheng, Chernoff Jonathan, Guo Jun, Boland Genevieve M., Sullivan Ryan J., Wei Zhi, Field Jeffrey, Amaravadi Ravi K., Flaherty Keith T., Herlyn Meenhard, Xu Xiaowei, Guo Wei. Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas, Nature 2019; 565(7738): E4
- Rebecca Vito W., Nicastri Michael C., Fennelly Colin, Chude Cynthia I., Barber-Rotenberg Julie S., Ronghe Amruta, McAfee Quentin, McLaughlin Noel P., Zhang Gao, Goldman Aaron R., Ojha Rani, Piao Shengfu, Noguera-Ortega Estela, Martorella Alessandra, Alicea Gretchen M., Lee Jennifer J., Schuchter Lynn M., Xu Xiaowei, Herlyn Meenhard, Marmorstein Ronen, Gimotty Phyllis A., Speicher David W., Winkler Jeffrey D., Amaravadi Ravi K.. PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer, Cancer Discovery 2019; 9(2): 220-229
- Liu Shujing, Zhang Gao, Guo Jianping, Chen Xiang, Lei Jingce, Ze Kan, Dong Liyun, Dai Xiangpeng, Gao Yang, Song Daisheng, Ecker Brett L., Yang Ruifeng, Feltcher Caitlin, Peng Kai, Feng Cheng, Chen Hui, Lee Rebecca X., Kerestes Heddy, Niu Jingwen, Kumar Suresh, Xu Weiting, Zhang Jie, Wei Zhi, Martin James S., Liu Xiaoming, Mills Gordon, Lu Yiling, Guo Wei, Sun Lunquan, Zhang Lin, Weeraratna Ashani, Herlyn Meenhard, Wei Wenyi, Lee Frank S., Xu Xiaowei. Author Correction: Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis, Nature Communications 2019; 10(1): article no. 1211-article no. 1211
- Sahu Avinash Das, S Lee Joo, Wang Zhiyong, Zhang Gao, Iglesias-Bartolome Ramiro, Tian Tian, Wei Zhi, Miao Benchun, Nair Nishanth Ulhas, Ponomarova Olga, Friedman Adam A., Amzallag Arnaud, Moll Tabea, Kasumova Gyulnara, Greninger Patricia, Egan Regina K., Damon Leah J., Frederick Dennie T., Jerby-Arnon Livnat, Wagner Allon, Cheng Kuoyuan, Park Seung Gu, Robinson Welles, Gardner Kevin, Boland Genevieve, Hannenhalli Sridhar, Herlyn Meenhard, Benes Cyril, Flaherty Keith, Luo Ji, Gutkind J. Silvio, Ruppin Eytan. Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy, Molecular Systems Biology 2019; 15(3): article no. e8323-article no. e8323
- Ojha Rani, Leli Nektaria M., Onorati Angelique, Piao Shengfu, Verginadis Ioannis I., Tameire Feven, Rebecca Vito W., Chude Cynthia I., Murugan Sengottuvelan, Fennelly Colin, Noguera-Ortega Estela, Liu Shujing, Xu Xiaowei, Krepler Clemens, Xiao Min, Xu Wei, Wei Zhi, Frederick Dennie T., Boland Genevieve, Mitchell Tara C., Karakousis Giorgos C., Schuchter Lynn M., Flaherty Keith T., Zhang Gao, Herlyn Meenhard, Koumenis Constantinos, Amaravadi Ravi K.. Er translocation of the mapk pathway drives therapy resistance in BRAF-mutant melanoma, Cancer Discovery 2019; 9(3): 396-415
- Atay Cigdem, Kwak Taekyoung, Lavilla-Alonso Sergio, Donthireddy Laxminarasimha, Richards Allison, Moberg Valerie, Pilon-Thomas Shari, Schell Michael, Messina Jane L., Rebecca Vito W., Xiao Min, Tan Jiufeng, Zhang Gao, Weber Jeffrey S., Herlyn Meenhard, Sarnaik Amod A., Gabrilovich Dmitry I.. BRAF targeting sensitizes resistant melanoma to cytotoxic T cells, Clinical Cancer Research 2019; 25(9): 2783-2794
- Buj Raquel, Chen Chi Wei, Dahl Erika S., Leon Kelly E., Kuskovsky Rostislav, Maglakelidze Natella, Navaratnarajah Maithili, Zhang Gao, Doan Mary T., Jiang Helen, Zaleski Michael, Kutzler Lydia, Lacko Holly, Lu Yiling, Mills Gordon B., Gowda Raghavendra, Robertson Gavin P., Warrick Joshua I., Herlyn Meenhard, Imamura Yuka, Kimball Scot R., DeGraff David J., Snyder Nathaniel W., Aird Katherine M.. Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming, Cell Reports 2019; 28(8): 1971-1980.e8
- Sugarman Eric T., Zhang Gao, Shay Jerry W.. In perspective: An update on telomere targeting in cancer, Molecular Carcinogenesis 2019; 58(9): 1581-1588
- Griss Johannes, Bauer Wolfgang, Wagner Christine, Simon Martin, Chen Minyi, Grabmeier-Pfistershammer Katharina, Maurer-Granofszky Margarita, Roka Florian, Penz Thomas, Bock Christoph, Zhang Gao, Herlyn Meenhard, Glatz Katharina, Läubli Heinz, Mertz Kirsten D., Petzelbauer Peter, Wiesner Thomas, Hartl Markus, Pickl Winfried F., Somasundaram Rajasekharan, Steinberger Peter, Wagner Stephan N.. B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma, Nature Communications 2019; 10(1): article no. 4186-article no. 4186
- Kwon So Mee, Budhu Anuradha, Woo Hyun Goo, Chaisaingmongkol Jittiporn, Dang Hien, Forgues Marshonna, Harris Curtis C., Zhang Gao, Auslander Noam, Ruppin Eytan, Mahidol Chulabhorn, Ruchirawat Mathuros, Wang Xin Wei. Functional Genomic Complexity Defines Intratumor Heterogeneity and Tumor Aggressiveness in Liver Cancer, Scientific Reports 2019; 9(1): article no. 16930-article no. 16930
- Aloia Andrea, Müllhaupt Daniela, Chabbert Christophe D., Eberhart Tanja, Flückiger-Mangual Stefanie, Vukolic Ana, Eichhoff Ossia, Irmisch Anja, Alexander Leila T., Scibona Ernesto, Frederick Dennie T., Miao Benchun, Tian Tian, Cheng Chaoran, Kwong Lawrence N., Wei Zhi, Sullivan Ryan J., Boland Genevieve M., Herlyn Meenhard, Flaherty Keith T., Zamboni Nicola, Dummer Reinhard, Zhang Gao, Levesque Mitchell P., Krek Wilhelm, Kovacs Werner J.. A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors, Clinical Cancer Research 2019; 25(22): 6852-6867
- Rebecca VW, Nicastri MC, Fennelly C, Chude CI, Barber-Rotenberg JS, Ronghe A, McAfee Q, McLaughlin NP, Zhang G, Goldman AR, Ojha R, Piao S, Noguera-Ortega E, Martorella A, Alicea GM, Lee JJ, Schuchter LM, Xu X, Herlyn M, Marmorstein R, Gimotty PA, Speicher DW, Winkler JD, Amaravadi RK. PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer, Cancer Discovery 2019; 9(2)
- Jenkins Russell W., Aref Amir R., Lizotte Patrick H., Ivanova Elena, Stinson Susanna, Zhou Chensheng W., Bowden Michaela, Deng Jiehui, Liu Hongye, Miao Diana, He Meng Xiao, Walker William, Zhang Gao, Tian Tian, Cheng Chaoran, Wei Zhi, Palakurthi Sangeetha, Bittinger Mark, Vitzthum Hans, Kim Jong Wook, Merlino Ashley, Quinn Max, Venkataramani Chandrasekar, Kaplan Joshua A., Portell Andrew, Gokhale Prafulla C., Phillips Bart, Smart Alicia, Rotem Asaf, Jones Robert E., Keogh Lauren, Anguiano Maria, Stapleton Lance, Jia Zhiheng, Barzily-Rokni Michal, Cañadas Israel, Thai Tran C., Hammond Marc R., Vlahos Raven, Wang Eric S., Zhang Hua, Li Shuai, Hanna Glenn J., Huang Wei, Hoang Mai P., Piris Adriano, Eliane Jean Pierre, Stemmer-Rachamimov Anat O., Cameron Lisa, Su Mei Ju, Shah Parin, Izar Benjamin, Thakuria Manisha, LeBoeuf Nicole R., Rabinowits Guilherme, Gunda Viswanath, Parangi Sareh, Cleary James M., Miller Brian C., Kitajima Shunsuke, Thummalapalli Rohit, Miao Benchun, Barbie Thanh U., Sivathanu Vivek, Wong Joshua, Richards William G., Bueno Raphael, Yoon Charles H., Miret Juan, Herlyn Meenhard, Garraway Levi A., Van Allen Eliezer M., Freeman Gordon J., Kirschmeier Paul T., Lorch Jochen H., Ott Patrick A., Stephen Hodi F., Flaherty Keith T., Kamm Roger D., Boland Genevieve M., Wong Kwok Kin, Dornan David, Paweletz Cloud Peter, Barbie David A.. Ex vivo profiling of PD-1 blockade using organotypic tumor spheroids, Cancer Discovery 2018; 8(2): 196-215
- Emran Abdullah Al, Marzese Diego M., Menon Dinoop Ravindran, Stark Mitchell S., Torrano Joachim, Hammerlindl Heinz, Zhang Gao, Brafford Patricia, Salomon Matthew P., Nelson Nellie, Hammerlindl Sabrina, Gupta Deepesh, Mills Gordon B., Lu Yiling, Sturm Richard A., Flaherty Keith, Dave S. B.Hoon, Gabrielli Brian, Herlyn Meenhard, Schaider Helmut. Distinct histone modifications denote early stress-induced drug tolerance in cancer, Oncotarget 2018; 9(9): 8206-8222
- Echevarría-Vargas Ileabett M., Reyes-Uribe Patricia I., Guterres Adam N., Yin Xiangfan, Kossenkov Andrew V., Liu Qin, Zhang Gao, Krepler Clemens, Cheng Chaoran, Wei Zhi, Somasundaram Rajasekharan, Karakousis Giorgos, Xu Wei, Morrissette Jennifer J.D., Lu Yiling, Mills Gordon B., Sullivan Ryan J., Benchun Miao, Frederick Dennie T., Boland Genevieve, Flaherty Keith T., Weeraratna Ashani T., Herlyn Meenhard, Amaravadi Ravi, Schuchter Lynn M., Burd Christin E., Aplin Andrew E., Xu Xiaowei, Villanueva Jessie. Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma, EMBO Molecular Medicine 2018; 10(5): article no. e8446-article no. e8446
- Zhang Gao, Wu Lawrence W., Mender Ilgen, Barzily-Rokni Michal, Hammond Marc R., Ope Omotayo, Cheng Chaoran, Vasilopoulos Themistoklis, Randell Sergio, Sadek Norah, Beroard Aurelie, Xiao Min, Tian Tian, Tan Jiufeng, Saeed Umar, Sugarman Eric, Krepler Clemens, Brafford Patricia, Sproesser Katrin, Murugan Sengottuvelan, Somasundaram Rajasekharan, Garman Bradley, Wubbenhorst Bradley, Woo Jonathan, Yin Xiangfan, Liu Qin, Frederick Dennie T., Miao Benchun, Xu Wei, Karakousis Giorgos C., Xu Xiaowei, Schuchter Lynn M., Mitchell Tara C., Kwong Lawrence N., Amaravadi Ravi K., Lu Yiling, Boland Genevieve M., Wei Zhi, Nathanson Katherine, Herbig Utz, Mills Gordon B., Flaherty Keith T., Herlyn Meenhard, Shay Jerry W.. Induction of telomere dysfunction prolongs disease control of therapy-resistant melanoma, Clinical Cancer Research 2018; 24(19): 4771-4784
- Cañadas Israel, Thummalapalli Rohit, Kim Jong Wook, Kitajima Shunsuke, Jenkins Russell William, Christensen Camilla Laulund, Campisi Marco, Kuang Yanan, Zhang Yanxi, Gjini Evisa, Zhang Gao, Tian Tian, Sen Debattama Rai, Miao Diana, Imamura Yu, Thai Tran, Piel Brandon, Terai Hideki, Aref Amir Reza, Hagan Timothy, Koyama Shohei, Watanabe Masayuki, Baba Hideo, Adeni Anika Elise, Lydon Christine Anne, Tamayo Pablo, Wei Zhi, Herlyn Meenhard, Barbie Thanh Uyen, Uppaluri Ravindra, Sholl Lynnette Marie, Sicinska Ewa, Sands Jacob, Rodig Scott, Wong Kwok Kin, Paweletz Cloud Peter, Watanabe Hideo, Barbie David Allen. Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses, Nature Medicine 2018; 24(8): 1143-1150
- Chen Gang, Huang Alexander C., Zhang Wei, Zhang Gao, Wu Min, Xu Wei, Yu Zili, Yang Jiegang, Wang Beike, Sun Honghong, Xia Houfu, Man Qiwen, Zhong Wenqun, Antelo Leonardo F., Wu Bin, Xiong Xuepeng, Liu Xiaoming, Guan Lei, Li Ting, Liu Shujing, Yang Ruifeng, Lu Youtao, Dong Liyun, McGettigan Suzanne, Somasundaram Rajasekharan, Radhakrishnan Ravi, Mills Gordon, Lu Yiling, Kim Junhyong, Chen Youhai H., Dong Haidong, Zhao Yifang, Karakousis Giorgos C., Mitchell Tara C., Schuchter Lynn M., Herlyn Meenhard, Wherry E. John, Xu Xiaowei, Guo Wei. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response, Nature 2018; 560(7718): 382-386
- Auslander Noam, Zhang Gao, Lee Joo Sang, Frederick Dennie T., Miao Benchun, Moll Tabea, Tian Tian, Wei Zhi, Madan Sanna, Sullivan Ryan J., Boland Genevieve, Flaherty Keith, Herlyn Meenhard, Ruppin Eytan. Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma, Nature Medicine 2018; 24(10): 1545-1549
- Huang Ming, Qi Tianyu F., Li Lin, Zhang Gao, Wang Yinsheng. A targeted quantitative proteomic approach assesses the reprogramming of small GTPases during melanoma metastasis, Cancer Research 2018; 78(18): 5431-5445
- Pathria Gaurav, Scott David A., Feng Yongmei, Sang Lee Joo, Fujita Yu, Zhang Gao, Sahu Avinash D., Ruppin Eytan, Herlyn Meenhard, Osterman Andrei L., Ronai Ze'ev A.. Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival, EMBO Journal 2018; 37(20): article no. e99735-article no. e99735
- Xiang Jiangdong, Zhou Lina, Zhuang Yan, Zhang Jin, Sun Ya, Li Shuangdi, Zhang Zhenbo, Zhang Gao, He Yinyan. Lactate dehydrogenase is correlated with clinical stage and grade and is downregulated by si-SATB1 in ovarian cancer, Oncology Reports 2018; 40(5): 2788-2797
- Simpkins Fiona, Jang Kibeom, Yoon Hyunho, Hew Karina E., Kim Minsoon, Azzam Diana J., Sun Jun, Zhao Dekuang, Ince Tan A., Liu Wenbin, Guo Wei, Wei Zhi, Zhang Gao, Mills Gordon B., Slingerland Joyce M.. Dual Src and MEK inhibition decreases ovarian cancer growth and targets tumor initiating stem-like cells, Clinical Cancer Research 2018; 24(19): 4874-4886
- Jerby-Arnon Livnat, Shah Parin, Cuoco Michael S., Rodman Christopher, Su Mei Ju, Melms Johannes C., Leeson Rachel, Kanodia Abhay, Mei Shaolin, Lin Jia Ren, Wang Shu, Rabasha Bokang, Liu David, Zhang Gao, Margolais Claire, Ashenberg Orr, Ott Patrick A., Buchbinder Elizabeth I., Haq Rizwan, Hodi F. Stephen, Boland Genevieve M., Sullivan Ryan J., Frederick Dennie T., Miao Benchun, Moll Tabea, Flaherty Keith T., Herlyn Meenhard, Jenkins Russell W., Thummalapalli Rohit, Kowalczyk Monika S., Cañadas Israel, Schilling Bastian, Cartwright Adam N.R., Luoma Adrienne M., Malu Shruti, Hwu Patrick, Bernatchez Chantale, Forget Marie Andrée, Barbie David A., Shalek Alex K., Tirosh Itay, Sorger Peter K., Wucherpfennig Kai, Van Allen Eliezer M., Schadendorf Dirk, Johnson Bruce E., Rotem Asaf, Rozenblatt-Rosen Orit, Garraway Levi A., Yoon Charles H., Izar Benjamin, Regev Aviv. A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade, Cell 2018; 175(4): 984-997.e24
- Zhang Gao, Shay Jerry W.. Inducing rapid telomere irreparable damage in telomerase-expressing cancers, Oncotarget 2018; 9(88): 35803-35804
- Liu Shujing, Zhang Gao, Guo Jianping, Chen Xiang, Lei Jingce, Ze Kan, Dong Liyun, Dai Xiangpeng, Gao Yang, Song Daisheng, Ecker Brett, Yang Ruifeng, Feltcher Caitlin, Peng Kai, Feng Cheng, Chen Hui, Lee Rebecca X., Kerestes Heddy, Niu Jingwen, Kumar Suresh, Xu Weiting, Zhang Jie, Wei Zhi, Martin James S., Liu Xiaoming, Mills Gordon, Lu Yiling, Guo Wei, Sun Lunquan, Zhang Lin, Weeraratna Ashani, Herlyn Meenhard, Wei Wenyi, Lee Frank S., Xu Xiaowei. Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis, Nature Communications 2018; 9(1): article no. 5426-article no. 5426
- Auslander Noam, Zhang Gao, Lee Joo Sang, Frederick Dennie T., Miao Benchun, Moll Tabea, Tian Tian, Wei Zhi, Madan Sanna, Sullivan Ryan J., Boland Genevieve, Flaherty Keith, Herlyn Meenhard, Ruppin Eytan. Publisher Correction: Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma, Nature Medicine 2018; 24(12): 1942
- Vitiello Marianna, Tuccoli Andrea, D'Aurizio Romina, Sarti Samanta, Giannecchini Laura, Lubrano Simone, Marranci Andrea, Evangelista Monica, Peppicelli Silvia, Ippolito Chiara, Barravecchia Ivana, Guzzolino Elena, Montagnani Valentina, Gowen Michael, Mercoledi Elisa, Mercatanti Alberto, Comelli Laura, Gurrieri Salvatore, Wu Lawrence W., Ope Omotayo, Flaherty Keith, Boland Genevieve M., Hammond Marc R., Kwong Lawrence, Chiariello Mario, Stecca Barbara, Zhang Gao, Salvetti Alessandra, Angeloni Debora, Pitto Letizia, Calorini Lido, Chiorino Giovanna, Pellegrini Marco, Herlyn Meenhard, Osman Iman, Poliseno Laura. Context-dependent miR-204 and miR-211 affect the biological properties of amelanotic and melanotic melanoma cells, Oncotarget 2017; 8(15): 25395-25417
- Leu Julia I.Ju, Barnoud Thibaut, Zhang Gao, Tian Tian, Wei Zhi, Herlyn Meenhard, Murphy Maureen E., George Donna L.. Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function, Oncotarget 2017; 8(28): 45656-45669
- Zhang Dongmei, Zhang Gao, Hu Xiaowen, Wu Lawrence, Feng Yi, He Sidan, Zhang Youyou, Hu Zhongyi, Yang Lu, Tian Tian, Xu Weiting, Wei Zhi, Lu Yiling, Flaherty Keith T., Zhong Xiaomin, Mills Gordon B., Gimotty Phyllis A., Xu Xiaowei, Herlyn Meenhard, Zhang Lin. Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer, Cancer Research 2017; 77(14): 3745-3757
- Somasundaram Rajasekharan, Zhang Gao, Fukunaga-Kalabis Mizuho, Perego Michela, Krepler Clemens, Xu Xiaowei, Wagner Christine, Hristova Denitsa, Zhang Jie, Tian Tian, Wei Zhi, Liu Qin, Garg Kanika, Griss Johannes, Hards Rufus, Maurer Margarita, Hafner Christine, Mayerhöfer Marius, Karanikas Georgios, Jalili Ahmad, Bauer-Pohl Verena, Weihsengruber Felix, Rappersberger Klemens, Koller Josef, Lang Roland, Hudgens Courtney, Chen Guo, Tetzlaff Michael, Wu Lawrence, Frederick Dennie Tompers, Scolyer Richard A., Long Georgina V., Damle Manashree, Ellingsworth Courtney, Grinman Leon, Choi Harry, Gavin Brian J., Dunagin Margaret, Raj Arjun, Scholler Nathalie, Gross Laura, Beqiri Marilda, Bennett Keiryn, Watson Ian, Schaider Helmut, Davies Michael A., Wargo Jennifer, Czerniecki Brian J., Schuchter Lynn, Herlyn Dorothee, Flaherty Keith, Herlyn Meenhard, Wagner Stephan N.. Tumor-associated B-cells induce tumor heterogeneity and therapy resistance, Nature Communications 2017; 8(1): article no. 607-article no. 607
- Zhang Ying, Kurupati Raj, Liu Ling, Zhou Xiang Yang, Zhang Gao, Hudaihed Abeer, Filisio Flavia, Giles-Davis Wynetta, Xu Xiaowei, Karakousis Giorgos C., Schuchter Lynn M., Xu Wei, Amaravadi Ravi, Xiao Min, Sadek Norah, Krepler Clemens, Herlyn Meenhard, Freeman Gordon J., Rabinowitz Joshua D., Ertl Hildegund C.J.. Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy, Cancer Cell 2017; 32(3): 377-391.e9
- Lu Hezhe, Liu Shujing, Zhang Gao, Wu Bin, Zhu Yueyao, Frederick Dennie T., Hu Yi, Zhong Wenqun, Randell Sergio, Sadek Norah, Zhang Wei, Chen Gang, Cheng Chaoran, Zeng Jingwen, Wu Lawrence W., Zhang Jie, Liu Xiaoming, Xu Wei, Krepler Clemens, Sproesser Katrin, Xiao Min, Miao Benchun, Liu Jianglan, Song Claire D., Liu Jephrey Y., Karakousis Giorgos C., Schuchter Lynn M., Lu Yiling, Mills Gordon, Cong Yusheng, Chernoff Jonathan, Guo Jun, Boland Genevieve M., Sullivan Ryan J., Wei Zhi, Field Jeffrey, Amaravadi Ravi K., Flaherty Keith T., Herlyn Meenhard, Xu Xiaowei, Guo Wei. PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas, Nature 2017; 550(7674): 133-136
- Rebecca Vito W., Nicastri Michael C., McLaughlin Noel, Fennelly Colin, McAfee Quentin, Ronghe Amruta, Nofal Michel, Lim Chun Yan, Witze Eric, Chude Cynthia I., Zhang Gao, Alicea Gretchen M., Piao Shengfu, Murugan Sengottuvelan, Ojha Rani, Levi Samuel M., Wei Zhi, Barber-Rotenberg Julie S., Murphy Maureen E., Mills Gordon B., Lu Yiling, Rabinowitz Joshua, Marmorstein Ronen, Liu Qin, Liu Shujing, Xu Xiaowei, Herlyn Meenhard, Zoncu Roberto, Brady Donita C., Speicher David W., Winkler Jeffrey D., Amaravadi Ravi K.. A unified approach to targeting the lysosome’s degradative and growth signaling roles, Cancer Discovery 2017; 7(11): 1266-1283
- Krepler Clemens, Sproesser Katrin, Brafford Patricia, Beqiri Marilda, Garman Bradley, Xiao Min, Shannan Batool, Watters Andrea, Perego Michela, Zhang Gao, Vultur Adina, Yin Xiangfan, Liu Qin, Anastopoulos Ioannis N., Wubbenhorst Bradley, Wilson Melissa A., Xu Wei, Karakousis Giorgos, Feldman Michael, Xu Xiaowei, Amaravadi Ravi, Gangadhar Tara C., Elder David E., Haydu Lauren E., Wargo Jennifer A., Davies Michael A., Lu Yiling, Mills Gordon B., Frederick Dennie T., Barzily-Rokni Michal, Flaherty Keith T., Hoon Dave S., Guarino Michael, Bennett Joseph J., Ryan Randall W., Petrelli Nicholas J., Shields Carol L., Terai Mizue, Sato Takami, Aplin Andrew E., Roesch Alexander, Darr David, Angus Steve, Kumar Rakesh, Halilovic Ensar, Caponigro Giordano, Jeay Sebastien, Wuerthner Jens, Walter Annette, Ocker Matthias, Boxer Matthew B., Schuchter Lynn, Nathanson Katherine L., Herlyn Meenhard. A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma, Cell Reports 2017; 21(7): 1953-1967
- Hew Karina E., Miller Philip C., El-Ashry Dorraya, Sun Jun, Besser Alexandra H., Ince Tan A., Gu Mengnan, Wei Zhi, Zhang Gao, Brafford Patricia, Gao Wei, Lu Yiling, Mills Gordon B., Slingerland Joyce M., Simpkins Fiona. MAPK activation predicts poor outcome and the MEK inhibitor, selumetinib, reverses antiestrogen resistance in ER-positive high-grade serous ovarian cancer, Clinical Cancer Research 2016; 22(4): 935-947
- Lu Hezhe, Liu Shujing, Zhang Gao, Kwong Lawrence N., Zhu Yueyao, Miller John P., Hu Yi, Zhong Wenqun, Zeng Jingwen, Wu Lawrence, Krepler Clemens, Sproesser Katrin, Xiao Min, Xu Wei, Karakousis Giorgos C., Schuchter Lynn M., Field Jeffery, Zhang Paul J., Herlyn Meenhard, Xu Xiaowei, Guo Wei. Oncogenic BRAF-Mediated Melanoma Cell Invasion, Cell Reports 2016; 15(9): 2012-2024
- Shannan Batool, Watters Andrea, Chen Quan, Mollin Stefan, Dörr Markus, Meggers Eric, Xu Xiaowei, Gimotty Phyllis A., Perego Michela, Li Ling, Benci Joseph, Krepler Clemens, Brafford Patricia, Zhang Jie, Wei Zhi, Zhang Gao, Liu Qin, Yin Xiangfan, Nathanson Katherine L., Herlyn Meenhard, Vultur Adina. PIM kinases as therapeutic targets against advanced melanoma, Oncotarget 2016; 7(34): 54897-54912
- Zhang Gao, Frederick Dennie T., Wu Lawrence, Wei Zhi, Krepler Clemens, Srinivasan Satish, Chae Young Chan, Xu Xiaowei, Choi Harry, Dimwamwa Elaida, Ope Omotayo, Shannan Batool, Basu Devraj, Zhang Dongmei, Guha Manti, Xiao Min, Randell Sergio, Sproesser Katrin, Xu Wei, Liu Jephrey, Karakousis Giorgos C., Schuchter Lynn M., Gangadhar Tara C., Amaravadi Ravi K., Gu Mengnan, Xu Caiyue, Ghosh Abheek, Xu Weiting, Tian Tian, Zhang Jie, Zha Shijie, Liu Qin, Brafford Patricia, Weeraratna Ashani, Davies Michael A., Wargo Jennifer A., Avadhani Narayan G., Lu Yiling, Mills Gordon B., Altieri Dario C., Flaherty Keith T., Herlyn Meenhard. Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors, Journal of Clinical Investigation 2016; 126(5): 1834-1856
- Wu Lawrence W., Zhang Gao, Herlyn Meenhard. Repurposing an HIV drug to improve efficacy of targeted therapy in melanoma, Translational Cancer Research 2016; 5: S106-S108
- Pytel Dariusz, Gao Yan, Mackiewicz Katarzyna, Katlinskaya Yuliya V., Staschke Kirk A., Paredes Maria C.G., Yoshida Akihiro, Qie Shuo, Zhang Gao, Chajewski Olga S., Wu Lawrence, Majsterek Ireneusz, Herlyn Meenhard, Fuchs Serge Y., Diehl J. Alan. PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma, PLoS Genetics 2016; 12(12): article no. e1006518-article no. e1006518
- Wu Lawrence W., Zhang Gao, Herlyn Meenhard. Mitochondrial biogenesis meets chemoresistance in BRAF-mutant melanoma, Molecular and Cellular Oncology 2016; 3(4): article no. e1179381-article no. e1179381
- Webster Marie R., Xu Mai, Kinzler Kathryn A., Kaur Amanpreet, Appleton Jessica, O'Connell Michael P., Marchbank Katie, Valiga Alexander, Dang Vanessa M., Perego Michela, Zhang Gao, Slipicevic Ana, Keeney Frederick, Lehrmann Elin, Wood William, Becker Kevin G., Kossenkov Andrew V., Frederick Dennie T., Flaherty Keith T., Xu Xiaowei, Herlyn Meenhard, Murphy Maureen E., Weeraratna Ashani T.. Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells, Pigment Cell and Melanoma Research 2015; 28(2): 184-195
- Kraya Adam A., Piao Shengfu, Xu Xiaowei, Zhang Gao, Herlyn Meenhard, Gimotty Phyllis, Levine Beth, Amaravadi Ravi K., Speicher David W.. Identification of secreted proteins that reflect autophagy dynamics within tumor cells, Autophagy 2015; 11(1): 60-74
- Wang Tao, Xiao Min, Ge Yingbin, Krepler Clemens, Belser Eric, Lopez-Coral Alfonso, Xu Xiaowei, Zhang Gao, Azuma Rikka, Liu Qin, Liu Rui, Li Ling, Amaravadi Ravi K., Xu Wei, Karakousis Giorgos, Gangadhar Tara C., Schuchter Lynn M., Lieu Melissa, Khare Sanika, Halloran Molly B., Herlyn Meenhard, Kaufman Russel E.. BRAF inhibition stimulates melanoma-associated macrophages to drive tumor growth, Clinical Cancer Research 2015; 21(7): 1652-1664
- Liu Shujing, Tetzlaff Michael T., Wang Tao, Yang Ruifeng, Xie Lin, Zhang Gao, Krepler Clemens, Xiao Min, Beqiri Marilda, Xu Wei, Karakousis Giorgos, Schuchter Lynn, Amaravadi Ravi K., Xu Weiting, Wei Zhi, Herlyn Meenhard, Yao Yuan, Zhang Litao, Wang Yingjie, Zhang Lin, Xu Xiaowei. miR-200c/Bmi1 axis and epithelial-mesenchymal transition contribute to acquired resistance to BRAF inhibitor treatment, Pigment Cell and Melanoma Research 2015; 28(4): 431-441
- Menon D. Ravindran, Das S., Krepler C., Vultur A., Rinner B., Schauer S., Kashofer K., Wagner K., Zhang G., Rad E. Bonyadi, Haass N. K., Soyer H. P., Gabrielli B., Somasundaram R., Hoefler G., Herlyn M., Schaider H.. Erratum: A stress-induced early innate response causes multidrug tolerance in melanoma, Oncogene 2015; 34(34): 4545
- Menon D. Ravindran, Das S., Krepler C., Vultur A., Rinner B., Schauer S., Kashofer K., Wagner K., Zhang G., Bonyadi Rad E., Haass N. K., Soyer H. P., Gabrielli B., Somasundaram R., Hoefler G., Herlyn M., Schaider H.. A stress-induced early innate response causes multidrug tolerance in melanoma, Oncogene 2015; 34(34): 4448-4459
- Ma Xiao Hong, Piao Sheng Fu, Dey Souvik, McAfee Quentin, Karakousis Giorgos, Villanueva Jessie, Hart Lori S., Levi Samuel, Hu Janice, Zhang Gao, Lazova Rossitza, Klump Vincent, Pawelek John M., Xu Xiaowei, Xu Wei, Schuchter Lynn M., Davies Michael A., Herlyn Meenhard, Winkler Jeffrey, Koumenis Constantinos, Amaravadi Ravi K.. Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma, Journal of Clinical Investigation 2014; 124(3): 1406-1417
- Zhang Gao, Herlyn Meenhard. Linking SOX10 to a slow-growth resistance phenotype, Cell Research 2014; 24(8): 906-907
- Balaburski Gregor M., Leu Julia I.Ju, Beeharry Neil, Hayik Seth, Andrake Mark D., Zhang Gao, Herlyn Meenhard, Villanueva Jessie, Dunbrack Roland L., Yen Tim, George Donna L., Murphy Maureen E.. A modified HSP70 inhibitor shows broad activity as an anticancer agent, Molecular Cancer Research 2013; 11(3): 219-229
- Aird Katherine M., Zhang Gao, Li Hua, Tu Zhigang, Bitler Benjamin G., Garipov Azat, Wu Hong, Wei Zhi, Wagner Stephan N., Herlyn Meenhard, Zhang Rugang. Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence, Cell Reports 2013; 3(4): 1252-1265
- Yang Y., Wu J., Demir A., Castillo-Martin M., Melamed R. D., Zhang G., Fukunaga-Kanabis M., Perez-Lorenzo R., Zheng B., Silvers D. N., Brunner G., Wang S., Rabadan R., Cordon-Cardo C., Celebi J. T.. GAB2 induces tumor angiogenesis in NRAS-driven melanoma, Oncogene 2013; 32(31): 3627-3637
- Rasanen Kati, Sriswasdi Sira, Valiga Alexander, Tang Hsin Yao, Zhang Gao, Perego Michela, Somasundaram Rajasekharan, Li Ling, Speicher Kaye, Klein-Szanto Andres J., Basu Devraj, Rustgi Anil K., Speicher David W., Herlyn Meenhard. Comparative secretome analysis of epithelial and mesenchymal subpopulations of head and neck squamous cell carcinoma identifies S100A4 as a potential therapeutic target, Molecular and Cellular Proteomics 2013; 12(12): 3778-3792
- Kumar S. M., Zhang G., Bastian B. C., Arcasoy M. O., Karande P., Pushparajan A., Acs G., Xu X.. Erythropoietin receptor contributes to melanoma cell survival in vivo, Oncogene 2012; 31(13): 1649-1660
- Wang Tao, Ge Yingbin, Xiao Min, Lopez-Coral Alfonso, Azuma Rikka, Somasundaram Rajasekharan, Zhang Gao, Wei Zhi, Xu Xiaowei, Rauscher Frank J., Herlyn Meenhard, Kaufman Russel E.. Melanoma-derived conditioned media efficiently induce the differentiation of monocytes to macrophages that display a highly invasive gene signature, Pigment Cell and Melanoma Research 2012; 25(4): 493-505
- Ge Yingbin, Azuma Rikka, Gekonge Bethsebah, Lopez-Coral Alfonso, Xiao Min, Zhang Gao, Xu Xiaowei, Montaner Luis J., Wei Zhi, Herlyn Meenhard, Wang Tao, Kaufman Russel E.. Induction of metallothionein expression during monocyte to melanoma-associated macrophage differentiation, Frontiers in Biology 2012; 7(4): 359-367
- Zhang Gao, Herlyn Meenhard. Human nevi: No longer precursors of melanomas?, Journal of Investigative Dermatology 2012; 132(9): 2133-2134
- Basu D., Nguyen T. T.K., Montone K. T., Zhang G., Wang L. P., Diehl J. A., Rustgi A. K., Lee J. T., Weinstein G. S., Herlyn M.. Evidence for mesenchymal-like sub-populations within squamous cell carcinomas possessing chemoresistance and phenotypic plasticity, Oncogene 2010; 29(29): 4170-4182
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Book Chapter
- Wu Lawrence W., Herlyn Meenhard, Zhang Gao. Tumor microenvironment for melanoma cells . Melanoma Development: Molecular Biology, Genetics and Clinical Application. Cham, Switzerland: Springer; 2017:357-368.
- Zhang Gao, Herlyn Meenhard
. Tumor Microenvironment for Melanoma Cells . Melanoma Development.. Springer Vienna; 2011:.
- 2009. Zhang G. Joanna M. Nicolay Melanoma Foundation's Research Scholarship Award.
- 2004. Zhang G. Joanna R. Baker Memorial Fellowship, the Graduate School at the UNC Charlotte.
- 18 March 2025: Zhang Gao, Su Yuxiong, Pu Jingya. https://www.hku.hk/press/press-releases/detail/28185.html.
- 21 September 2022: Zhang Gao. Understanding and Overcoming Adaptive Response, Primary and Acquired Resistance to Targeted Therapy and Immunotherapy in Advanced Cancers.
- 10/2018 - present: Member. Society for Neuro-Oncology.
- 01/2021 - present: Member. Society for Functional Precision Medicine.
- 01/2012 - present: Member. American Association for Cancer Research.
- 01/2005 - 12/2018: Associate Member. The Institute for the Translational Medicine and Therapeutics, University of Pennsylvania.
- Project Title: Contrasting and Distinguishing Therapy-induced Senescence from Replicative Senescence and Oncogene-induced Senescence at the Molecular Level
Grant Type: Healthy Longevity Catalyst Awards (Hong Kong) 2024
Funding Year: 2024
Amount: HK$388,981
Principal Investigator: Professor Zhang, Gao
Co-investigator(s): Professor Huang Yuanhua, Professor Cheung Martin Chi Hang
- Project Title: Precision Medicine in Oncology: Bridging Laboratory Discoveries and Clinical Innovations
Grant Type: Croucher Advanced Study Institutes
Funding Year: 2024
Amount: HK$518,000
Principal Investigator: Professor Zhang, Gao
- Project Title: Discovering prognostic biomarkers for pulpotomy outcome in permanent mature teeth with irreversible pulpitis
Grant Type: General Research Fund (GRF) 2023/24
Funding Year: 2023
Amount: HK$1,532,000
Principal Investigator: Professor Zhang, Chengfei
Co-investigator(s): Professor Wang Junwen John, Professor Lee Angeline Hui Cheng, Professor Zhang Gao, Professor Wu Zhaoming
- Project Title: The functional roles of minerals and vitamins in human diseases – an AI/informatics approach
Grant Type: Seed Fund for Collaborative Research
Funding Year: 2022
Amount: HK$400,000
Principal Investigator: Professor Wang, Junwen John
Co-principal investigator(s): Emeritus Professor Flemmig Thomas Frank, Professor McGrath Colman, Professor Zhang Gao, Professor Lee Victor Ho Fun, Professor Yang Yanqi, Professor Su Yuxiong
- 18 October 2024: Application of single-cell sequencing and multi-omics in precise diagnosis of diseases
. 2024 Zhejiang Pharmaceutical Association In Vitro Diagnostics Academic Conference (18/10/2024-19/10/2024, Hangzhou ).
- 01 December 2023: Understanding and Overcoming Adaptive Response, Primary and Acquired Resistance to Targeted Therapy and Immunotherapy in Advanced Cancers. The Sixth Annual Meeting of the Precision Cancer Medicine Professional Committee of the Hunan Anti-Cancer Association and the New Progress Study Class on Precision Cancer Medicine and the Lung Cancer Expert Forum of the Hunan Geriatrics Society (01/12/2023-02/12/2023, Changsha).
- 08 November 2023: Multi-omics Analyses of Brain Metastasis and Therapeutic Resistance of Cancers at the Single Cell and Spatial Levels. Scientific research and academic exchange meeting (08/11/2023-08/11/2023, Anyang).
- 27 May 2023: Multi-omics Analyses of Brain Metastasis and Therapeutic Resistance of Cancers at the Single Cell and Spatial Levels
. Cancer Precision Medicine Summit Forum (27/05/2023-27/05/2023, Changsha ).
- 12 May 2023: Molecular Mechanisms of Therapeutic Resistance and Brain Metastasis
. Lecture Hall of International Famous Teachers (12/05/2023-12/05/2023, Chengdu).
- 06 April 2023: Genomic and Immunogenomic Landscape of Immunotherapy-Refractory Tumors and Brain Metastases
. Invited Lecture (06/04/2023-06/04/2023, Guangzhou).
- 21 September 2022: Understanding and Overcoming Adaptive Response, Primary and Acquired Resistance to Targeted Therapy and Immunotherapy in Advanced Cancers
. Invitied Lecture by Faculty of Dentistry at HKU (21/09/2022-21/09/2022, Sai Ying Pun).
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- 01 June 2025-Present: Discontinuation, Committee on. 1 member from each Faculty (Dentistry) from a panel of three in order of precedence for a period of 2 years, renewable up to a maximum of 4 consecutive years
- 26 August 2022-Present: Faculty of Dentistry, Board of the. The teachers who are members of the Faculty and who are full-time employees of the University
- All publication and awards data are automatically fetched periodically from the .
