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李璇

Professor Li, Xuan

BEng(SWJTU), MMed(SWJTU), PhD(HKU), MRSC

Professor Li, Xuan 李璇 - HKU Faculty of Dentistry 香港大學牙醫學院

Profile

Title
  • Assistant Professor in Tissue Engineering and Regeneration
    組織工程與再生學助理教授
Division
Applied Oral Sciences & Community Dental Care
E-mail
llx815@hku.hk
Phone
+852 2859 0270
Research Theme
Craniofacial Regeneration
Areas of Research Expertise
  • Nano/micromaterials for oral healthcare
  • Host-oral microbe interaction
  • Natural/herbal bioactive compounds
Research Profile
Publication & Awards
Publications

    Article

  • Wu Zichen, Xu Ke, Huang Regina, Wang Xinna, Teng Jade Lee Lee, Yu Xiaolin, Jin Lijian, Li Quanli, Leung Ken Cham Fai, Wong Hai Ming, Li Xuan. Cyborg microbe biohybrids with metal–organic coating layers: Strategies, functionalisation and potential applications, Materials Today Bio 2025; 31 doi:10.1016/j.mtbio.2025.101642
  • Hu Qin, Leung Wai Keung, Acharya Aneesha, Li Xuan, Pelekos George. Akkermansia muciniphila Alleviates Porphyromonas gingivalis-induced Periodontal Disease by Enhancing Bacterial Clearance, Probiotics and Antimicrobial Proteins 2025; doi:10.1007/s12602-025-10541-2
  • Li Xuan, Huang Regina, Li Pugeng, Tang Fung Kit, He Jing, Sun Hanyu, Wang Xiaoyu, Wang Miao, Lan Xinmiao, Wang Xinna, Wong Sarah Sze Wah, Jin Lijian, Leung Ken Cham-Fai, Wong Hai Ming, Wang Sheng, Guo Lanping, Ding Pei-Hui, Yu Xiaolin. Berberine-Functionalized Bismuth-Doped Carbon Dots in a Pathogen-Responsive Hydrogel System: A Multifaceted Approach to Combating Periodontal Diseases, ACS Nano 2025; 19(18): 17554-17577 doi:10.1021/acsnano.5c00561
  • Xu Ke, Huang Regina, Li Xuan, Jin Lijian, Ko Chung Nga, Li Min, Wong Hai Ming, Leung Ken Cham Fai. Nanomaterial-based synergistic strategies for combating dental caries: progress and perspectives , Nanoscale 2024; doi:10.1039/d4nr04515g
  • Wang Chuan, Wang Leilei, Li Xuan, Jin Lijian, Cao Zhengguo. Porphyromonas gingivalis persisters induce the immuno-inflammatory responses in macrophages by upregulating the forkhead box1 signaling pathway, Chinese journal of stomatology 2024; 59(7): 672-680 doi:10.3760/cma.j.cn112144-20231114-00248
  • Wang Leilei, Wang Chuan, Li Xuan, Tao Zhuoying, Zhu Wangyong, Su Yuxiong, Choi Wing Shan. Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS, Cellular & Molecular Biology Letters 2023; 28(1) doi:10.1186/s11658-023-00449-6
  • Lan XM, Zhong J, Huang R, Liu YH, Ma XW, Li X, Zhao D, Qing GC, Zhang YX, Liu L, Wang JJ, Ma X, Luo T, Guo WS, Wang YJ, Li LL, Su YX, Liang XJ. Conformation Dependent Architectures of Assembled Antimicrobial Peptides with Enhanced Antimicrobial Ability, Advanced Healthcare Materials 2023; doi:10.1002/adhm.202301688
  • Li X, Wang C, WANG L, HUANG R, Li W, Wang X, Wong SSW, Cai Z, Leung KCF, Jin L. A glutathione-responsive silica-based nanosystem capped with in-situ polymerized cell-penetrating poly(disulfide)s for precisely modulating immuno-inflammatory responses, Journal of Colloid and Interface Science 2022; 614: 322-336 doi:10.1016/j.jcis.2022.01.091
  • WANG C, Li X, Cheng T, WANG L, Jin L. RNA Sequencing Reveals the Upregulation of FOXO Signaling Pathway in Porphyromonas gingivalis Persister-Treated Human Gingival Epithelial Cells, International Journal of Molecular Sciences 2022; 23: 5728-5728 doi:10.3390/ijms23105728
  • Sun H, Chan YK, Li X, Xu R, Zhang Z, Hu X, Wu F, Deng F, Yu X. Multi-omics analysis of oral bacterial biofilm on titanium oxide nanostructure modified implant surface: In vivo sequencing-based pilot study in beagle dogs, Materials Today Bio 2022; 15: 100275-100275 doi:10.1016/j.mtbio.2022.100275
  • Huang Regina, Hu Qin, Ko Chung-Nga, Tang Fung Kit, Xuan Shouhu, Wong Hai Ming, Jin Lijian, Li Xuan, Leung Ken Cham-Fai. Nano-based theranostic approaches for infection control: current status and perspectives, Materials Chemistry Frontiers 2022; 8(1): 9-40 doi:10.1039/D3QM01048A
  • WANG C, Li X, Cheng T, Sun H, Jin L. Eradication of Porphyromonas gingivalis Persisters Through Colloidal Bismuth Subcitrate Synergistically Combined With Metronidazole, Frontiers in Microbiology 2021; 12: article no. 748121-article no. 748121 doi:10.3389/fmicb.2021.748121
  • WANG C, Cheng T, Li X, Jin L. Metronidazole-Treated Porphyromonas gingivalis Persisters Invade Human Gingival Epithelial Cells and Perturb Innate Responses, Antimicrobial Agents and Chemotherapy 2020; 64(6): article no. e02529-19 doi:10.1128/AAC.02529-19
  • Chung ACK, Li X, Li WC, Wang T, Lee HK, Jin L, Cai Z, Leung KCF. Mass spectrometry imaging and monitoring of in vivo glutathione-triggered cisplatin release from nanoparticles in the kidneys, Nanoscale Advances 2020; 2(12): 5857-5865 doi:10.1039/D0NA00708K
  • Leung KCF, Li XB, Li X, Lee SF, Yu JC, Mendes PM, Hermann KE, Van Hove MA. Soft Nanohand Grabs a Growing Nanoparticle, Materials Chemistry Frontiers 2019; 3(8): 1555-1564 doi:10.1039/C9QM00132H
  • Li X, Huang R, Tang FK, Li WC, Wong SSW, Leung KCF, Jin L. Red-Emissive Guanylated Polyene-Functionalized Carbon Dots Arm Oral Epithelia against Invasive Fungal Infections, ACS Applied Materials & Interfaces 2019; 11: 46591-46603 doi:10.1021/acsami.9b18003
  • Li X, Li X, Wang S, Leung CFK, Zhang C, Jin L. Infiltration and Profiles of Mesoporous Silica Nanoparticles in Dentinal Tubules, ACS Biomaterials Science & Engineering 2018; 4: 1428-1436 doi:10.1021/acsbiomaterials.7b00919
  • Lan X, She J, Lin D, Xu Y, Li X, Yang W, Lui VWY, Jin L, Xie X, Su Y. Microneedle-Mediated Delivery of Lipid-Coated Cisplatin Nanoparticles for Efficient and Safe Cancer Therapy, ACS Applied Materials & Interfaces 2018; 10(39): 33060-33069 doi:10.1021/acsami.8b12926
  • LI X, Luo W, Ng TC, Leung PC, Zhang C, Leung CFK, Jin L. Nanoparticle-encapsulated baicalein markedly modulates pro-inflammatory response in gingival epithelial cells, Nanoscale 2017; 9: 12897-12907 doi:10.1039/C7NR02546G
  • Leung KCF, Seneviratne CJ, Li X, Leung PC, Lau CBS, Wong CH, Pang KY, Wong CW, Wat E, Jin L. Synergistic Antibacterial Effects of Nanoparticles Encapsulated with Scutellaria baicalensis and Pure Chlorhexidine on Oral Bacterial Biofilms, Nanomaterials 2016; 6: 61-61 doi:10.3390/nano6040061
  • LI X, Wong CH, Ng TW, Zhang C, Leung KCF, Jin L. The spherical nanoparticle-encapsulated chlorhexidine enhances anti-biofilm efficiency through an effective releasing mode and close microbial interactions, International Journal of Nanomedicine 2016; 11: 2471-2471 doi:10.2147/IJN.S105681
  • LI X, Pang KY, Ng TW, Leung PC, Zhang C, Leung KCF, Jin L. Cellular Interactions and Formation of an Epithelial “Nanocoating-Like Barrier” with Mesoporous Silica Nanoparticles, Nanomaterials 2016; 6: 192-192 doi:10.3390/nano6110192
  • Seneviratne CJ, Leung CFK, Wong CH, Lee SF, LI X, Leung PC, Lau CBS, Wat E, Jin L. Nanoparticle-encapsulated chlorhexidine against oral bacterial biofilms, PLoS ONE 2014; 9: e103234-e103234 doi:10.1371/journal.pone.0103234
  • Wang Sheng, Guo Lan Ping, Xie Teng, Yang Jian, Tang Jin Fu, Li Xuan, Wang Xiao, Huang Lu Qi. Different secondary metabolic responses to MeJA treatment in shikonin-proficient and shikonin-deficient cell lines from Arnebia euchroma (Royle) Johnst, Plant Cell, Tissue and Organ Culture 2014; 119(3): 587-598 doi:10.1007/s11240-014-0558-5
  • Li Xuan, Yue Hong, Wang Sheng, Huang Lu Qi, Ma Jiong, Guo Lan Ping. Research of different effects on activity of plant antioxidant enzymes, Zhongguo Zhongyao Zazhi 2013; 38(7): 973-978 doi:10.4268/cjcmm20130709
  • Guo Lan Ping, Wang Sheng, Zhang Ji, Yang Guang, Zhao Man Xi, Ma Wei Feng, Zhang Xiao Bo, Li Xuan, Han Bang Xing, Chen Nai Fu, Huang Lu Qi. Effects of ecological factors on secondary metabolites and inorganic elements of Scutellaria baicalensis and analysis of geoherblism, Science China Life Sciences 2013; 56(11): 1047-1056 doi:10.1007/s11427-013-4562-5
  • Li Xuan, Wang Sheng, Guo Lanping, Huang Luqi. Effect of cadmium in the soil on growth, secondary metabolites and metal uptake in Salvia miltiorrhiza, Toxicological and Environmental Chemistry 2013; 95(9): 1525-1538 doi:10.1080/02772248.2014.887717
  • Zhou Jie, Fang Lei, Li Xuan, Guo Lanping, Huang Luqi. Jasmonic acid (JA) acts as a signal molecule in LaCl3-induced baicalin synthesis in Scutellaria baicalensis seedlings, Biological Trace Element Research 2012; 148(3): 392-395 doi:10.1007/s12011-012-9379-8
  • Wang Sheng, Li Xuan, Jiang Chao, Guo Lan Ping. Advances in studies on genes related to shikonin and its derivatives biosynthesis and signal transduction, Chinese Traditional and Herbal Drugs 2012; 43(6): 1219-1225
  • Li Xuan, Zhao Manxi, Guo Lanping, Huang Luqi. Effect of cadmium on photosynthetic pigments, lipid peroxidation, antioxidants, and artemisinin in hydroponically grown Artemisia annua, Journal of Environmental Sciences (China) 2012; 24(8): 1511-1518 doi:10.1016/S1001-0742(11)60920-0

    • Show More

    Conference Paper

  • Huang R, Li X, Leung CFK, Jin L. Ultrasound-assisted synthesis of bismuth-metal organic frameworks for suppressing Porphyromonas gingivalis, Journal of Dental Research (Spec Issue) 2021; 100(Spec Iss A): presentation ID 2109-presentation ID 2109
  • Li X, HUANG R, Fang FK, Li WC, Wong SSW, Leung CFK, Jin L. Oral epithelia enhanced by red-emitting amphotericin b-conjugated carbon dots perturb the adherence and invasion of Candida albicans, The 11th World Biomaterials Congress (WBC 2020) 2020;
  • HUANG R, Li X, Leung CFK, Jin L. Antibiotic-free, bismuth-doped carbon dots for suppression on P. gingivalis, The 11th World Biomaterials Congress (WBC 2020) 2020;
  • Wang C, Li X, Cheng T, Jin L. Metronidazole-tolerant Porphyromonas gingivalis persisters dampen cytokine expression in HGECs, Journal of Dental Research (Spec Issue) 2019; 98(Spec Iss A): abstract no. 2313-abstract no. 2313

    • PG Thesis

  • Li Xuan Mesoporous silica nanoparticle-encapsulated antimicrobials and Chinese herbal extracts : controlling oral microbes, modulating immuno-inflammatory response & perspectives[PG Thesis]. Pokfulam, Hong Kong: The University of Hong Kong; 2017. doi:10.5353/th_991044014360103414
Professional Societies
  • 06/2020-06/2023: MRSC. Royal Society of Chemistry.
Grants
  • Project Title: Novel injectable hydrogels encapsulated with bismuth-doped carbon dots-based nanomedicine for periodontal treatment and healthcare via antimicrobial & immuno-modulatory approaches
    Grant Type: Health and Medical Research Fund - Full Grant
    Funding Year: 2020
    Amount: HK$1,090,248
    Principal Investigator: Dr Li, Xuan
    Co-investigator(s): Dr Cheng Tianfan, Dr Lan Xinmiao, Dr Leung Ken Cham-fai, Professor Jin Lijian, Dr Yu Xiaolin, Dr Wong Sze Wah Sarah
  • Project Title: A pioneering study on nano-reinforced multifunctional ‘barrier’ of human gingival epithelia loaded with nanoparticles-based antimicrobials and immunoinflammatory modulators
    Grant Type: General Research Fund (GRF)
    Funding Year: 2018
    Amount: HK$1,356,480
    Principal Investigator: Professor Jin, Lijian
    Co-investigator(s): Dr Leung Ken Cham-fai, Dr Li Xuan
Invited Lectures & Keynote Speeches
  • 31 July 2020: Nano-based drug delivery system for oral/periodontal healthcare: An update and perspective. 1st ‘Young Researchers Forum of IADR - Asia Pacific Region’.

Note

  • All publication and awards data are automatically fetched periodically from the HKU Scholars Hub.