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李昱輝

Professor Li, Yuhui

PhD (XJTU)

Professor Li, Yuhui 李昱輝 - HKU Faculty of Dentistry 香港大學牙醫學院

Profile

Title
  • Assistant Professor in Mechanobiology
    力學生物學助理教授
Division
Applied Oral Sciences & Community Dental Care
E-mail
yuhuili@hku.hk
Phone
+852 2859 0277
Biography
Professor Li received his Ph.D. in Biomedical Engineering from Xi’an Jiaotong University (China), where his work focused on engineering skeletal muscle tissues using microscale hydrogels. Professor Li later moved to France and worked at the CytomorphoLab (Grenoble and Paris) with Manuel Théry and Laurent Blanchoin, where he studied cytoskeletal dynamics and mechanosensation in living cells. During this time, he also developed expansion microscopy to investigate the ultrastructural organisation of centrioles. Then, he worked with Jean-Léon Maitre at the Institut Curie (Paris) to study cytoskeletal organisation and mechanics in preimplantation mouse embryos. Professor Li’s interests are dedicated to uncovering the fundamental biophysical principles that govern cell and tissue organisation, with the ultimate goal of advancing regenerative medicine and tissue engineering.
Research Theme
Craniofacial Regeneration
Areas of Research Expertise
  • Cytoskeleton dynamics and organisation
  • Reconstitution of the dental cell microenvironment
  • Embryo/Organoid mechanics
  • Ultrastructure of centriole
  • Expansion microscopy
Research Profile
Publication & Awards
Publications

    Article

  • Shi Nianyuan, Li Yuhui, Chang Le, Zhao Guoxu, Jin Guorui, Lyu Yi, Genin Guy M., Ma Yufei, Xu Feng. A 3D, Magnetically Actuated, Aligned Collagen Fiber Hydrogel Platform Recapitulates Physical Microenvironment of Myoblasts for Enhancing Myogenesis, Small Methods 2021; 5(6): article no. 2100276-article no. 2100276 doi:10.1002/smtd.202100276
  • Chang Le, Li Yuhui, Li Moxiao, Liu Shaobao, Han Jiyang, Zhao Guoxu, Ji Changchun, Lyu Yi, Genin Guy M., Bai Bofeng, Xu Feng. An Injectable, biodegradable magnetic hydrogel system for exogenous promotion of muscle mass and regeneration, Chemical Engineering Journal 2021; 420: article no. 130398-article no. 130398 doi:10.1016/j.cej.2021.130398
  • Qin Yuan, Li Yuhui, Zhang Li Yuan, Xu Guang Kui. Stochastic fluctuation-induced cell polarization on elastic substrates: A cytoskeleton-based mechanical model, Journal of the Mechanics and Physics of Solids 2020; 137: article no. 103872-article no. 103872 doi:10.1016/j.jmps.2020.103872
  • Li Jing, Wang Sufang, Li Yuhui, Zhang Nu, Gribskov Michael, Zhang Xi, Lin Min, Shao Dongyan, Zhang Chen, Dai Liangliang, Qin Chuanguang, Duan Xianglong, Li Juntang, Xu Feng, Yang Hui. miRNA-mediated macrophage behaviors responding to matrix stiffness and ox-LDL, Journal of Cellular Physiology 2020; 235(9): 6139-6153 doi:10.1002/jcp.29543
  • Cheng Bo, Wan Wanting, Huang Guoyou, Li Yuhui, Genin Guy M., Mofrad Mohammad R.K., Lu Tian Jian, Xu Feng, Lin Min. Nanoscale integrin cluster dynamics controls cellular mechanosensing via FAKY397 phosphorylation, Science Advances 2020; 6(10): article no. eaax1909-article no. eaax1909 doi:10.1126/sciadv.aax1909
  • Li Yu Hui, Li Dong Sheng, Wang Mei Qing, Zhao Kai, Gao Bu Lang. Modified hemispherectomy for infantile hemiparesis and epilepsy, Translational Neuroscience 2020; 11(1): 380-390 doi:10.1515/tnsci-2020-0145
  • Zhuang Minghao, Liu Zhenjing, Ding Yao, Xu Gui Liang, Li Yuhui, Tyagi Abhishek, Zhang Xiaoyi, Sun Cheng Jun, Ren Yang, Ou Xuewu, Wong Hoilun, Cai Yuting, Wu Ruizhe, Abidi Irfan Haider, Zhang Qicheng, Xu Feng, Amine Khalil, Luo Zhengtang. Methacrylated gelatin-embedded fabrication of 3D graphene-supported Co 3 O 4 nanoparticles for water splitting, Nanoscale 2019; 11(14): 6866-6875 doi:10.1039/c8nr10369k
  • Shi Qiang, Liu Hao, Tang Deding, Li Yuhui, Li Xiu Jun, Xu Feng. Bioactuators based on stimulus-responsive hydrogels and their emerging biomedical applications, Npg Asia Materials 2019; 11(1): article no. 64-article no. 64 doi:10.1038/s41427-019-0165-3
  • Li Yuhui, Hong Yuan, Xu Guang Kui, Liu Shaobao, Shi Qiang, Tang Deding, Yang Hui, Genin Guy M., Lu Tian Jian, Xu Feng. Non-contact tensile viscoelastic characterization of microscale biological materials, Acta Mechanica Sinica Lixue Xuebao 2018; 34(3): 589-599 doi:10.1007/s10409-017-0740-1
  • Li Jing, Li Yuhui, Gao Bin, Qin Chuanguang, He Yining, Xu Feng, Yang Hui, Lin Min. Engineering mechanical microenvironment of macrophage and its biomedical applications, Nanomedicine 2018; 13(5): 555-576 doi:10.2217/nnm-2017-0324
  • Liu Hao, Li Moxiao, Li Yuhui, Yang Hui, Li Ang, Lu Tian Jian, Li Fei, Xu Feng. Magnetic steering of liquid metal mobiles, Soft Matter 2018; 14(17): 3236-3245 doi:10.1039/c8sm00056e
  • Ma Yufei, Lin Min, Huang Guoyou, Li Yuhui, Wang Shuqi, Bai Guiqin, Lu Tian Jian, Xu Feng. 3D Spatiotemporal Mechanical Microenvironment: A Hydrogel-Based Platform for Guiding Stem Cell Fate, Advanced Materials 2018; 30(49): article no. 1705911-article no. 1705911 doi:10.1002/adma.201705911
  • Xu Feng, Zhang Xiaohui, Bao Xuejiao, Zhao Guoxu, Liu Fusheng, Huang Guoyou, Li Yuhui, Lu Tianjian. Engineering mechanical-electrical cell microenvironment in myocardium using advanced biomaterials, Advances in Mechanics 2018; 48(1): 320-359 doi:10.6052/1000-0992-17-014
  • Ng Kelvin, Gao Bin, Yong Kar Wey, Li Yuhui, Shi Meng, Zhao Xin, Li Zedong, Zhang Xiao Hui, Pingguan-Murphy Belinda, Yang Hui, Xu Feng. Paper-based cell culture platform and its emerging biomedical applications, Materials Today 2017; 20(1): 32-44 doi:10.1016/j.mattod.2016.07.001
  • Cheng Bo, Lin Min, Huang Guoyou, Li Yuhui, Ji Baohua, Genin Guy M., Deshpande Vikram S., Lu Tian Jian, Xu Feng. Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses, Physics of Life Reviews 2017; 22-23: 88-119 doi:10.1016/j.plrev.2017.06.016
  • Cheng Bo, Lin Min, Huang Guoyou, Li Yuhui, Ji Baohua, Genin Guy M., Deshpande Vikram S., Lu Tian Jian, Xu Feng. Energetics: An emerging frontier in cellular mechanosensing: Reply to comments on “Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses”, Physics of Life Reviews 2017; 22-23: 130-135 doi:10.1016/j.plrev.2017.09.003
  • Huang Guoyou, Li Fei, Zhao Xin, Ma Yufei, Li Yuhui, Lin Min, Jin Guorui, Lu Tian Jian, Genin Guy M., Xu Feng. Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment, Chemical Reviews 2017; 117(20): 12764-12850 doi:10.1021/acs.chemrev.7b00094
  • Huang Guoyou, Li Moxiao, Yang Qingzhen, Li Yuhui, Liu Hao, Yang Hui, Xu Feng. Magnetically actuated droplet manipulation and its potential biomedical applications, ACS Applied Materials and Interfaces 2017; 9(2): 1155-1166 doi:10.1021/acsami.6b09017
  • Tang Deding, Shi Nianyuan, Chang Le, Shi Qiang, Li Yuhui, Xu Feng. Fabrication of Hydrogel Fiber with Enhanced Mechanical Property and Biocompatibility Evaluation, Hsi an Chiao Tung Ta Hsueh Journal of Xi an Jiaotong University 2017; 51(12): 150-155 doi:10.7652/xjtuxb201712022
  • Li Yuhui, Huang Guoyou, Li Moxiao, Wang Lin, Elson Elliot L., Jian Lu Tian, Genin Guy M., Xu Feng. An approach to quantifying 3D responses of cells to extreme strain, Scientific Reports 2016; 6: article no. 19550-article no. 19550 doi:10.1038/srep19550
  • Wang Lin, Li Yuhui, Huang Guoyou, Zhang Xiaohui, Pingguan-Murphy Belinda, Gao Bin, Lu Tian Jian, Xu Feng. Hydrogel-based methods for engineering cellular microenvironment with spatiotemporal gradients, Critical Reviews in Biotechnology 2016; 36(3): 553-565 doi:10.3109/07388551.2014.993588
  • Yong Kar Wey, Li Yuhui, Liu Fusheng, Gao Bin, Lu Tian Jian, Wan Abas Wan Abu Bakar, Wan Safwani Wan Kamarul Zaman, Pingguan-Murphy Belinda, Ma Yufei, Xu Feng, Huang Guoyou. Paracrine effects of adipose-derived stem cells on matrix stiffness-induced cardiac myofibroblast differentiation via angiotensin II type 1 receptor and smad7, Scientific Reports 2016; 6: article no. 33067-article no. 33067 doi:10.1038/srep33067
  • Cheng Bo, Lin Min, Li Yuhui, Huang Guoyou, Yang Hui, Genin Guy M., Deshpande Vikram S., Lu Tian Jian, Xu Feng. An Integrated Stochastic Model of Matrix-Stiffness-Dependent Filopodial Dynamics, Biophysical Journal 2016; 111(9): 2051-2061 doi:10.1016/j.bpj.2016.09.026
  • Li Yuhui, Huang Guoyou, Gao Bin, Li Moxiao, Genin Guy M., Lu Tian Jian, Xu Feng. Magnetically actuated cell-laden microscale hydrogels for probing strain-induced cell responses in three dimensions, Npg Asia Materials 2016; 8(1): article no. e238-article no. e238 doi:10.1038/am.2015.148
  • Qi Hao, Huang Guoyou, Han Yulong, Zhang Xiaohui, Li Yuhui, Pingguan-Murphy Belinda, Lu Tian Jian, Xu Feng, Wang Lin. Engineering Artificial Machines from Designable DNA Materials for Biomedical Applications, Tissue Engineering Part B Reviews 2015; 21(3): 288-297 doi:10.1089/ten.teb.2014.0494
  • Wang Lin, Qiu Mushu, Yang Qingzhen, Li Yuhui, Huang Guoyou, Lin Min, Lu Tian Jian, Xu Feng. Fabrication of microscale hydrogels with tailored microstructures based on liquid bridge phenomenon, ACS Applied Materials and Interfaces 2015; 7(21): 11134-11140 doi:10.1021/acsami.5b00081
  • Wang Lin, Li Yuhui, Chen Bin, Liu Shaobao, Li Moxiao, Zheng Lu, Wang Pengfei, Lu Tian Jian, Xu Feng. Patterning Cellular Alignment through Stretching Hydrogels with Programmable Strain Gradients, ACS Applied Materials and Interfaces 2015; 7(27): 15088-15097 doi:10.1021/acsami.5b04450
  • Yong Kar Wey, Li Yuhui, Huang Guoyou, Lu Tian Jian, Zaman Wan Safwani Wan Kamarul, Pingguan-Murphy Belinda, Xu Feng. Mechanoregulation of cardiac myofibroblast differentiation: Implications for cardiac fibrosis and therapy, American Journal of Physiology Heart and Circulatory Physiology 2015; 309(4): H532-H542 doi:10.1152/ajpheart.00299.2015
  • Li Yuhui, Poon Chi Tat, Li Moxiao, Lu Tian Jian, Pingguan-Murphy Belinda, Xu Feng. Chinese-noodle-inspired muscle myofiber fabrication, Advanced Functional Materials 2015; 25(37): 5999-6008 doi:10.1002/adfm.201502018
  • Zhang Xiaohui, Liu Man, Li Yuhui, Dong Yuqing, Pingguan-Murphy Belinda, Lu Tian Jian, Xu Feng. Engineering cell microenvironment using novel functional hydrogels, European Polymer Journal 2015; 72: 590-601 doi:10.1016/j.eurpolymj.2015.03.019
  • Li Yuhui, Li Xiang, Zheng Lu, Wang Lin, Zhang Xiaohui, Xu Feng. Polyacrylamide/GelMA hydrogel templates for breast cancer cell spheroids fabrication, Journal of Nanotechnology in Engineering and Medicine 2015; 6(3): article no. 034501-article no. 034501 doi:10.1115/1.4031898
  • Shi Meng, Ling Kai, Weyyong Kar, Li Yuhui, Feng Shangsheng, Zhang Xiaohui, Pingguan-Murphy Belinda, Lu Tian Jian, Xu Feng. High-Throughput Non-Contact Vitrification of Cell-Laden Droplets Based on Cell Printing, Scientific Reports 2015; 5(1): article no. 17928-article no. 17928 doi:10.1038/SREP17928
  • Li Yuhui, Huang Guoyou, Zhang Xiaohui, Wang Lin, Du Yanan, Lu Tian Jian, Xu Feng. Engineering cell alignment in vitro, Biotechnology Advances 2014; 32(2): 347-365 doi:10.1016/j.biotechadv.2013.11.007
  • Han Yu Long, Wang Shuqi, Zhang Xiaohui, Li Yuhui, Huang Guoyou, Qi Hao, Pingguan-Murphy Belinda, Li Yinghui, Lu Tian Jian, Xu Feng. Engineering physical microenvironment for stem cell based regenerative medicine, Drug Discovery Today 2014; 19(6): 763-773 doi:10.1016/j.drudis.2014.01.015
  • Lu Tingli, Li Yuhui, Chen Tao. Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering, International Journal of Nanomedicine 2013; 8: 337-350 doi:10.2147/IJN.S38635
  • Li Yuhui, Huang Guoyou, Zhang Xiaohui, Li Baoqiang, Chen Yongmei, Lu Tingli, Lu Tian Jian, Xu Feng. Magnetic hydrogels and their potential biomedical applications, Advanced Functional Materials 2013; 23(6): 660-672 doi:10.1002/adfm.201201708

    • Show More

    Conference Paper

  • Lu Tingli, Li Yuhui, Wang Yunqing, Ma Yufan. Preparation and characterization of porous nano-sized hydroxyapatite/collagen composite as bone scaffold, Advanced Materials Research 2013; 647: 62-66 doi:10.4028/www.scientific.net/AMR.647.62
HKU Committee Appointments
  • 01 September 2025-Present: Faculty of Dentistry, Board of the. The teachers who are members of the Faculty and who are full-time employees of the University

Note

  • All publication and awards data are automatically fetched periodically from the HKU Scholars Hub.